Moderate gap junctional uncoupling with carbenoxolone slows conduction and increases vulnerability to ventricular arrhythmias—an optical mapping study (original) (raw)

2010

Abstract

ABSTRACT It is uncertain whether moderate conduction slowing through gap junctional uncoupling on its own, in the absence of action potential or structural changes, is sufficient to be pro-arrhythmic. We used optical mapping: (1) to study the effects of carbenoxolone (CBX), a gap junction uncoupler, on conduction velocity and action potential duration and (2) to assess the effects of moderate conduction slowing and gap junctional uncoupling on arrhythmia vulnerability in structurally normal hearts.

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