Investigation of the influence of training status on the relationship between the acute exercise and serum leptin levels in obese females (original) (raw)
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Hormone and Metabolic Research, 2014
cise in relation to energy expenditure [11]. In normal as well as in obese subjects, a period of prolonged physical training also promotes a decrease in leptin [12, 13]. Regular exercise is an important strategy in the management of obesity, together with hypocaloric diet and appropriate lifestyle. The aim of this study was to elucidate in obesity the behaviour of leptin after a comparable type of training at work loads of different intensity, that is: 1) after exclusively aerobic work, and 2) after aerobic work plus a bout of anaerobic work. On the basis of previous observations on GH and nonesterified fatty acids (NEFAs) [14, 15], we might presume different behaviours of leptin with regard to differences in quantity of physical training.
Effects of aerobic exercise on serum leptin levels in obese women
European Journal of Applied Physiology and Occupational Physiology, 1999
It has been demonstrated that leptin concentrations in obese patients may be altered by weight loss. We examined the effects of a 9-week aerobic exercise program on serum leptin concentrations in overweight women (20-50% above ideal body mass) under conditions of weight stability. Sixteen overweight women, mean (SE) age 42.75 (1.64) years. comprised the exercise group which adhered to a supervised aerobic exercise program. A graded exercise treadmill test was conducted before and after the exercise program to determine maximal oxygen uptake ( V O~, , ,~~) using open-circuit spirometry. The women denlollstrated improved aerobic fitness (i/0?,,, increased 12.29O/0), however, body fat and the body mass index did not change significantly [42.27 (1.35)-41.87 (1.33)%]. Fourteen women, age 40.57 (2.80) years, did not exercise over the same time period and served as a control group. Serum leptin levels were not significantly altered for either the exercise [28.00 (2.13)-3 1.04 (2.7 1) ng ml-'1 or the control group L33.24 (3.78)-34.69 (3.14) ng . mg-'1. The data indicate that 9 weeks of aerobic exercise improves aerobic fitness, but does not affect leptin concentrations in overweight women.
2013
Background: Leptin resistance is one of the influential factors on hyperinsuhnisrn and finally on lack of the glucose tolerance in overweight and its related diseases. Thus the goal of this research is to study the response of Leplin Plasnra. 17-bela estradiol serum and insulin to 24-weeks aerobic exerctse In inactive obese women. Method: The research was of semi-experimental kind 15 inactive obese women were chosen randontly and were categorized in two different groups, i.e. aerr:bic exercise and control. The exercise process included aerobic exercises for 6 months (three 60-minute sessions per week).we used repeated measure for variation the. time x group. The Independent sample T test was applied tct cornpare the average amounts betwecrr groLtps. Result: The results represent that the influence of time has not been identical orr arnount of leptin seTum, insulin, the body nrass index and fat amount, and a 24-weeks ac.roDrc exerctse caused a significant decrease in this field (P<...
Sport Sciences for Health, 2008
Six young obese females (20.5±1.22 years; BMI=34.5±4.3 kg/m2) participated in a resistance exercise (RE) protocol (12 exercises, 4 sets × 15 repetitions at 60% of 1RM), an aerobic exercise (AE) protocol (3 sets × 10 min ergometer cycling at 60% of maximal heart rate with 5 min of rest between sets), and a control session. Blood samples were collected before, and immediately after and 10 h after exercise. All protocols were done in follicular phase of the menstrual cycle. ANOVA (3×3) with repeated measure on exercise (3 levels) and time (3 levels) factors was used to determine the effects of exercise protocol, time and exercise protocol by blood sampling time interaction, triglycerides, HDL-cholesterol, LDL-cholesterol, and glucose concentrations. Immediately and 10 h after AE, serum leptin was significantly lower (p<0.05). Serum insulin after AE was lower than after RE and control sessions (p<0.05). Furthermore, no significant differences were found in serum leptin and insulin between RE and control sessions immediately after and 10 h after exercise. Blood glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were unchanged in both exercise protocols. In conclusion, AE resulted in a serum leptin reduction and suppressed the circadian rhythm of serum insulin when sampled immediately and 10 h after exercise; instread, RE did not result in serum leptin or insulin changes.
The study focused on the influence of a 9-week monitored energy deficit on serum leptin level in 16 obese women. Additionally, measurements of body components and total cholesterol (CHO), HDL cholesterol (HDL) and triacylglycerols (TRG) concentration in blood were carried out, concentration of LDL cholesterol (LDL) was evaluated. Energy deficit was induced by a diet and "fat burning" type exercises. Leptin concentration in blood serum was significantly higher before (41.7±16.5 ng/ml) than after the accomplishment of experiment (24.7±16.2 ng/ml). Body mass decreased, which was mainly due to a drop in body fat (from 36.6±13.9 kg to 29.0±12.5 kg). All changes have been statistically significant at the level of P<0.001. A significant decrease of CHO (from 187.926.3 mg/dl to 167.125.4 mg/dl; P<0.001) and LDL (from 115.525.1 mg/dl to 102.321.5 mg/dl; P<0.05) concentration in blood was noticed. However, changes in HDL and TRG concentration were statistically insignificant. There was a statistically significant correlation (P<0.05) recorded between changes in leptin concentration in blood and changes in body mass, BMI and body fat (0.51; 0.58; 0.64 respectively). No correlation was observed between leptin and lean body mass, CHO, HDL, LDL or TRG.
Plasma leptin and exercise: recent findings
Sports medicine, 2001
stimulates lipid metabolism, and increases energy expenditure. These effects implicate leptin as a major regulator of energy homeostasis, which may serve to limit excess energy storage. As plasma leptin concentrations are tightly coupled with fat mass in humans, decreases in adipose mass with weight loss coincide with decreased concentrations of circulating leptin. However, due to many confounding factors, the effects of exercise on circulating leptin are less clear. The data from investigations examining single exercise bouts suggest that serum leptin concentrations are unaltered by short duration (41 minutes or less), non-exhaustive exercise, but may be affected by short duration, exhaustive exercise. More convincingly, studies investigating long duration exercise bouts indicate that serum leptin concentrations are reduced with exercise durations ranging from one to multiple hours. These findings raise speculation that exercise-associated reductions in leptin may be due to alterations in nutrient availability or nutrient flux at the level of the adipocytes, the primary site of leptin production and secretion. Thus, one purpose of this review is to discuss the effects of exercise on circulating leptin concentrations with special emphasis on studies that have examined single exercise bouts that are associated with high levels of energy expenditure and energy deficit. In addition, a 'nutrient sensing pathway' (the hexosamine biosynthetic pathway), which regulates leptin gene expression, will be discussed as a possible mechanism by which exercise-induced energy deficit may modulate serum leptin concentrations.
Leptin, its implication in physical exercise and training: a short review
Journal of sports science & medicine, 2006
Leptin, a hormone synthesized by fat tissue had been noted to regulate energy balance and metabolism and thus to influence body weight. The influence of acute exercise and chronic exercise training on circulating leptin and its relationship with hormonal and metabolic changes that induce energy balance are presented. Research that has examined the influence of exercise under various experimental conditions on leptin and the conflicts in the literature are presented. It appears that a significant caloric perturbation (> 800 kcals) is necessary for acute exercise to result in a significant reduction in leptin. In contrast, exercise training can result in a leptin decline but typically this manifests a reduction in adipose tissue stores. In addition, future directions are presented. Key PointsPhysical exercise and training have both inhibitory and stimulatory effects on leptin.Exercise with energy expenditure higher than 800 kcal can decrease leptinemia.Acute training may cause a de...
Intensity of Acute Exercise Does Not Affect Serum Leptin Concentrations in Young Men
Journal of Cardiopulmonary Rehabilitation, 2001
Purpose: We examined the effects of exercise intensity on serum leptin levels. Methods: Seven men (age = 27.0 yr; height = 178.3 cm; weight = 82.2 kg) were tested on a control (C) day and on 5 exercise days (EX). Subjects exercised (30 min) at the following intensities: 25% and 75% of the difference between the lactate threshold (LT) and rest (0.25 LT, 0.75 LT), at LT, and at 25% and 75% of the difference between LT and peak O V 2 (1.25 LT, 1.75 LT). Results: Kcal expended during the exercise bouts ranged from 150 ± 11 kcal (0.25 LT) to 529 ± 45 kcal (1.75 LT), whereas exercise + 3.5 h recovery kcal ranged from 310 ± 14 kcal (0.25 LT) to 722 ± 51 kcal (1.75 LT). Leptin area under the curve (AUC) (Q 10-min samples) for all six conditions (C + 5 Ex) was calculated for baseline (0700-0900 h) and for exercise + recovery (0900-1300 h). Leptin AUC for baseline ranged from 243 ± 33 to 291 ± 56 ng~mL-1 X min; for exercise + recovery results ranged from 424 ± 56 to 542 ± 99 ng~mL-1 X min. No differences were observed among conditions within either the baseline or exercise + recovery time frames. Regression analysis confirmed positive relationships between serum leptin concentrations and percentage body fat (r = 0.94) and fat mass (r = 0.93, P < 0.01). Conclusion: We conclude that 30 min of acute exercise, at varying intensity of exercise and caloric expenditure, does not affect serum leptin concentrations during exercise or for the first 3.5 hours of recovery in healthy young men.
International Journal of Cardiology, 2009
Six young obese females (20.5±1.22 years; BMI=34.5±4.3 kg/m 2 ) participated in a resistance exercise (RE) protocol (12 exercises, 4 sets × 15 repetitions at 60% of 1RM), an aerobic exercise (AE) protocol (3 sets × 10 min ergometer cycling at 60% of maximal heart rate with 5 min of rest between sets), and a control session. Blood samples were collected before, and immediately after and 10 h after exercise. All protocols were done in follicular phase of the menstrual cycle. ANOVA (3×3) with repeated measure on exercise (3 levels) and time (3 levels) factors was used to determine the effects of exercise protocol, time and exercise protocol by blood sampling time interaction, triglycerides, HDL-cholesterol, LDL-cholesterol, and glucose concentrations. Immediately and 10 h after AE, serum leptin was significantly lower (p<0.05). Serum insulin after AE was lower than after RE and control sessions (p<0.05). Furthermore, no significant differences were found in serum leptin and insulin between RE and control sessions immediately after and 10 h after exercise. Blood glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were unchanged in both exercise protocols. In conclusion, AE resulted in a serum leptin reduction and suppressed the circadian rhythm of serum insulin when sampled immediately and 10 h after exercise; instread, RE did not result in serum leptin or insulin changes.