Evaluation of CT Scan and MRI Findings of Pathologically (original) (raw)
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OMICS Journal of Radiology, 2015
Aim: The aim of this study is to characterize the site, types and radiological features of gliomas, such as edema, mass effect, and type of enhancement on CT-scan and MRI imaging. Patients and methods: Thirty-three patients were studied retrospectively from the PACS system of multi-slice CT-scanner and MRI using the protocol of imaging of the head and spine. Results: Gliomas involved male patients more than females (60.1% vs. 39.9%). About 96.9% of the gliomas were in the brain and only 3.1% was in the cervical spine. Nearly 51.5% of the gliomas showed radiographic features of low-grade gliomas and 48.5% showed radiographic features of high-grade gliomas. Approximately 30% of gliomas were located at the parietal lobe of the brain. Nearly 45.5% of the gliomas showed heterogenous enhancement, 36.4% marginal enhancement and 5.1% had no enhancement after contrast administration. Conclusion: Gliomas were more common in male than female and high grade in elderly while low-grade gliomas in children. Gliomas were mostly involving the parietal lobes. The majority of gliomas showed heterogeneous enhancement after contrast administration. Magnetic resonance imaging is the most effective imaging method to characterize gliomas.
Radio-graphical Features of Gliosarcoma on Computed Tomography and Magnetic Resonance Imaging
International Journal of Trend in Scientific Research and Development, 2017
Gliosarcoma is a rare type of glioma, a brain that comes from glial, or supportive, brain cells, as opposed to the neural brain cells. Gliosarcoma is a malignant cancer, and is defined as a glioblastoma consisting of gliomatous and sarcomatous components. The aim of the study is to characterize the radiographic features of gliosarcoma, such as existence nature, content and appearance and enhancement on Computed Tomography and Magnetic Resonance Imaging. And also to find out which is the most effective imaging method to diagnose and categorize gliosarcoma. Fifteen patients were studied retrospectiv PACS system of CT scanner and MRI using the protocol of imaging of the head. The study reveals that majority(93.3%) of the gliosarcoma were single. About 80 percent of the gliosarcoma had both solid and cystic components. All fifteen tumors appeared to be relatively well demarcated from the surrounding edematous brain parenchyma. On T2-weighted image eight shows of hyperintensity and isointensity. The study concludes that Gadolinium enhanced Magnetic Resonance Imaging is more accurate than plain MRI, plain CT, Contrast Enhanced CT in defining the margins of Gliosarcoma.
Brainstem gliomas in adults: prognostic factors and classification
Brain, 2001
In contrast to childhood brainstem gliomas, adult brainstem gliomas are rare and poorly understood. The charts of 48 adults suffering from brainstem glioma were reviewed in order to determine prognostic factors, evaluate the effect of treatment and propose a classification of these tumours. Mean age at onset was 34 years (range 16-70 years). The main presenting symptoms were gait disturbance (61%), headache (44%), weakness of the limbs (42%) and diplopia (40%). Four patterns were identified on MRI, representing nonenhancing, diffusely infiltrative tumours (50%), contrastenhancing localized masses (31%), isolated tectal tumours (8%) and other patterns (11%). Treatment consisted of partial resection (8%), radiotherapy (94%) and chemotherapy (56%). Overall median survival was 5.4 years. On univariate analysis, the following favourable prognostic factors were identified (P < 0.01): age of onset <40 years, duration of symptoms before diagnosis >3 months, Karnofski performance status >70, low-grade histology, absence of contrast enhancement and 'necrosis' on MRI. On multivariate analysis, the duration of symptoms, the appearance of 'necrosis' on MRI and the histological grade of the tumour remained significant and independent prognostic factors (P < 0.05). Eighty-five percent of the tumours could be classified into one of the following three groups on the basis of clinical, radiological Abbreviations: CI ϭ confidence interval; NF1 ϭ neurofibromatosis type 1
Gaceta de M�xico, 2020
Introduction: Gliomas are neoplasms with high recurrence and mortality. Due to the difficulty to apply the World Health Organization (2016) classification, developing countries continue to use histological evaluation to diagnose and classify these neoplasms. Objective: To develop a semi-quantitative scale to numerically grade gliomas by its morphological characteristics. Method: A cohort of patients with gliomas was assessed and followed for 36 months. Tumor tissue sections were analyzed and graded, including aspects such as cell line, cellularity, nuclear pleomorphism, mitosis, endothelial hyperplasia, hypoxic changes, apoptotic bodies, necrosis, hemorrhage and proliferation index. Results: 58 cases were analyzed. Low-grade gliomas median score was 12 points (9 and 13.5 for percentiles 25 and 75, respectively), whereas for high-grade gliomas it was 17 points (16 and 20.5 for percentiles 25 and 75, respectively) (p < 0.0001). Thirty-six-month survival of patients with low (13/17) and high grade gliomas (6/41) was also significantly different (p < 0.0001). Conclusions: The semi-quantitative morphological scale allows an objective evaluation of gliomas, with an adequate correlation between the score, tumor grade and survival time.
2022
Introduction: Primary Brain tumors which include a 1.7 percent of all cancers among which glioblastomas are the most lethal and the most frequent malignant types. Ionizing radiation and some genetic factors have been reported as the etiology of such cancers. We are reporting the trends in the Brain tumors with a focus on malignant types and its outcome in the South of the Iran for the first time.Methods: We selected all the patients with primary brain tumors who undergone brain surgery at teaching hospitals the Shiraz Medical School between 2001 and 2017. Data was obtained from Fars Population-based Cancer Registry. ICD-O-3 morphology coding system according to WHO 2007 classification of CNS tumors was used for grouping the tumors. Using SPSS, Total Growth Rate (TGR) and Incidence Rate (IR) were calculated to assess the changes overtime.Results: A total number of 2130 (male: 890, 41.8% and female: 1240, 58.2%) brain tumor cases from 2001 to 2017 were included in this study. The high...
Asian Journal of Neurosurgery, 2019
Introduction: Tumors are the second-most common cause of death after cardiovascular diseases. Due to the high prevalence and mortality rate, brain tumors are of great importance and makeup about 5% of all tumors. Different types of brain tumors have their special pattern based on age, sex, complaints on admission, radiological signs and sometimes, their family history and seem these patterns are changing according to the geographic region over time. In this study, we evaluate the incidence of brain tumors in the northwest of Iran. Materials and Methods: All patients with brain tumor diagnosis that were hospitalized between April 2011 and March 2016 evaluated. Exclusion criteria were considered as secondary tumors of the central nervous system (CNS) (metastases) and duplicate records for the recurrent disease of the same patient. Data collected from their documents and analyzed with SPSS version 16. Results: In the present study, male to female (M: F) ratio is 1:1. 92.5% of tumors are primary in which meningiomas (22%) and glioblastoma multiforme (GBM) (19.6%) are the most common types. The rarest tumor types are neurocytoma (0.3%) and chondroid chordoma (0.3%). GBM is the most common tumor in the male population and meningiomas are most common in females. Medulloblastoma and meningioma with a median age of 11 and 58 years, respectively, were known as the most common primary CNS malignancy of the youngest and oldest age of study group. Conclusion: The obtained data from this study revealed that age and sex are associated with the tumor types, which is consistent with the previous results. Brain tumors involvement pattern is changing in male patients somehow there is a tendency of involving more aggressive and malignant tumor types in male individuals could be seen.
Adult brainstem gliomas - retrospective analysis of 51 patients
Turkish Neurosurgery, 2016
the specific pathology all BSG must be considered malignant because their localization itself is inoperable (23). These tumors are most often localized in pons, often with infiltration in other regions of the brainstem (16). They characteristically present with multiple cranial nerve deficits, ataxia and long tract dysfunction (5,6,10). The simplest classification of BSG is into two groups as focal and diffuse (4,8). More complex grading system defined subtypes of tumors of the brainstem, according to localization, the presence of hydrocephalus and hemorrhage and growth model (5,7,11,13). AIm: Brainstem gliomas (BSG) constitute less than 2% of brain tumors in adults. Therapeutic options are limited and BSG are associated with a high morbidity and mortality. mATERIAl and mEThODS: We reviewed the records of 51 patients with BSG treated at the Institute of Neurosurgery, Clinical Center of Serbia in Belgrade between 1998 and 2012. We recorded demographic and clinical variables as well as radiological findings and survival. RESUlTS: Of the 51 patients, 62.7% were male and 37.3% were female. The mean age was 30.6±19.3 years. High grade glioma (Astrocytoma grade III and IV) was most common at the age of 38.2±17.9 years (t=.481, p=0.017) while low grade glioma (Astrocytoma grade I and II) was common in younger age as 25.4±17.4 years (X 2 =4.013; p=0.045), with localization in the pons (X 2 =5.299; p=0.021) and exophytic presentation (X 2 =3.862; p=0.049). Ataxia, as initial symptom, was a predictor of poor outcome (HR:5.546, p=0.012). CONClUSION: Due to its specific localization, BSG present a major challenge for neurosurgery, because of the necessity of safe approach for radical resection. Histological verification of BSG determines the need for additional therapeutic procedures such as radiotherapy and chemotherapy. Benefit from correct diagnosis is reflected in the avoidance of potentially adverse effects of treatment.