Folding of the polyketide chain is not dictated by minimal polyketide synthase in the biosynthesis of mithramycin and anthracycline (original) (raw)

1997, Chemistry & Biology

AI-generated Abstract

This study investigates the biosynthesis of mithramycin and anthracycline, focusing on the role of minimal polyketide synthase (PKS) in the folding of aromatic polyketide chains. Using Streptomyces strains, it is demonstrated that the folding is not dictated by minimal PKS. Instead, the interactions of other PKS components are influential, revealing that the minimal PKS is not essential for catalyzing the complex structural transformations required for antibiotic production.

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