Associations between dietary macronutrients and the lipophilic index in human biomembranes (original) (raw)

Abstract

It has been demonstrated clearly that changes in fatty acids (FA) profile were common features observed in the metabolic syndrome, obesity, diabetes and cardiovascular diseases (CVD) [1-2]. It was recently proposed a novel index – Lipophilic Index, that uses the sum of individual FA, based on FA affinity and fluidity in relation to CHD risk [3], instead of individual FA contribution. In the present work we examined the correlations between dietary macronutrients and "simplified model" of LI in RBCs biomembranes. Blood was sampled after an overnight fast and analysed to measure glucose, triacylglycerols (TAG), total cholesterol, high density lipoproteins cholesterol (HDL-c), ApoA1 and ApoB by enzymatic and turbidimetric techniques (Roche Diagnostics). Dietary intake was determined using a validated semi-quantitative food frequency questionnaire (FFQ) [2], and the FA profile of RBCs by gas chromatography as previously reported [4]. The lipophilic index (LI) was determined by...

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