ANCA Diagnostics in Clinical Practice: New Developments (original) (raw)

Anti-neutrophil cytoplasmic antibodies (ANCA) are crucial in diagnosing ANCA-associated vasculitis (AAV), which includes conditions like granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). Recent developments in classification and detection techniques, particularly the introduction of antigen-specific assays for PR3 and MPO, have enhanced the clinical utility of ANCA testing. The paper reviews the evolution of ANCA diagnostics, current consensus methodologies, and offers insights into the technological advancements shaping their implementation in clinical practice.