Study of wheezing and its risk factors in the first year of life in the Province of Salamanca, Spain.: The EISL Study (original) (raw)

Wheezing and risk factors in the first year of life in Cantabria, Spain. The EISL study

Allergologia et immunopathologia, 2015

To determine the prevalence of wheezing during the first year of life in Cantabria, Spain and its associated risk factors. A cross-sectional, multicentre, descriptive epidemiological study was carried out in a representative sample of 958 infants in the first year of life, born in Cantabria. A previously validated and standardised written questionnaire was completed by the parents of infants seen between 12 and 15 months of age in the Primary Care Centres. The prevalence of wheezing was 32.7%. A relationship was found with male gender (OR 1.38, 95%CI [1.05-1.81]), the presence of a sibling (OR 2.43 [1.38-3.98]), attending nursery school (OR 2.40 [1.71-3.35]), exclusive breastfeeding for <3 months (OR 1.47 [1.12-1.93]), a first cold at ≤3 months (OR 2.07 [1.56-2.74]), asthma in siblings (OR 2.17 [1.25-3.77]), parental allergic rhinitis (OR 1.62 [1.10-2.37]) and paracetamol use >1 a week (OR 2.49 [1.31-4.73]), and maternal smoking during pregnancy (OR 2.18 [1.51-3.15]). The prev...

Prevalence and risk factors associated with wheezing in the first year of life

Jornal de Pediatria, 2014

Objective: to investigate the prevalence and risk factors associated with wheezing in infants in the first year of life. Methods: this was a cross-sectional study, in which a validated questionnaire (Estudio Internacional de Sibilancias en Lactantes -International Study of Wheezing in Infants -EISL) was applied to parents of infants aged between 12 and 15 months treated in 26 of 85 primary health care units in the period between 2006 and 2007. The dependent variable, wheezing, was defined using the following standards: occasional (up to two episodes of wheezing) and recurrent (three or more episodes of wheezing). The independent variables were shown using frequency distribution to compare the groups. Measures of association were based on odds ratio (OR) with a confidence interval of 95% (95% CI), using bivariate analysis, followed by multivariate analysis (adjusted OR [aOR]). Results: a total of 1,029 (37.7%) infants had wheezing episodes in the first 12 months of life; of these, 16.2% had recurrent wheezing. Risk factors for wheezing were family history of asthma (OR = 2.12; 95% CI: 1.76-2.54) and six or more episodes of colds (OR = 2.38; 95% CI: 1.91-2.97) and pneumonia (OR = 3.02; 95% CI: 2.43-3.76). For recurrent wheezing, risk factors were: familial asthma (aOR = 1.73; 95% CI 1.22---2.46); early onset wheezing (aOR = 1.83; 95% CI: 1.75-3.75); nocturnal symptoms (aOR = 2.56; 95% CI: 1.75-3.75), and more than six colds (aOR = 2.07; 95% CI 1.43-.00). ଝ Please cite this article as: Bessa OAAC, Leite ÁJM, Solé D, Mallol J. Prevalence and risk factors associated with wheezing in the first year of life. J Pediatr (Rio J). 2013. http://dx.---7 ARTICLE IN PRESS +Model 2

Recurrent wheezing: prevalence and associated factors in infants from Buenos Aires City, Argentina

Boletín Médico del Hospital Infantil de México (English Edition)

Background: The episodes of bronchial obstruction at early age constitute a frequent problem in Pediatrics. This study aimed to evaluate the prevalence of recurrent wheezing in infants in Buenos Aires City and to identify its associated factors. Methods: a Cross-sectional study performed from 2011 to 2012 in the Children Hospital Ricardo Gutiérrez, Buenos Aires City, as part of the International Study of Wheezing in Infants. A validated questionnaire was applied to parents of infants aged between 12 and 15 months. The wheezing prevalence, mainly in recurrent patients (three or more episodes) was evaluated, and its likely associated factors. Data were statistically analyzed employing χ 2 test, Fisher's test, binary, and logistics multiple regression analysis, with a significance level of 0.05. Results: Over 1063 infants, 58.9% (confidence interval (CI) 95% 55.9-61.9) had at least one episode of wheezing and 26.3% (CI95% 23.8-29.9) had three or more episodes (recurrent wheezing). Risk factors associated to wheezing were male sex (p = 0.001), six or more episodes of cold during the first year of life (p < 0.0001), age at first cold <4 months (p < 0.0001); pneumonia (p < 0.0001) and tobacco smoking during pregnancy (p = 0.01). For recurrent wheezing, risk factors we considered as six or more episodes of cold during the first year of life (p < 0.0001), early (< 4 month old) onset wheezing (p < 0.0001) and nocturnal wheezing (p < 0.0001). Conclusions: The prevalence of recurrent wheezing among infants in Buenos Aires City was high (26.3%). Some identified associated factors can be preventable.

Risk Factors for Wheezing Disorders in Infants in the First Year of Life Living in Sao Paulo, Brazil

Journal of Tropical Pediatrics, 2012

The objective of this study was to identify risk factors for wheezing disorders in the first year of life in infants living in Sa˜o Paulo (SP), Brazil, applying the standardized protocol of the Estudio Internacional de sibilancia en lactentes-Phase 1. A total of 1014 parents or caregivers of infants, who attended for routine evaluation and immunization in public health centers were interviewed in Southern SP city. Risk factors significantly associated with recurrent wheezing were: history of previous pneumonia, daycare attendance, consumption of processed food, presence of a cat at home, more than five upper respiratory infection (URI) episodes and the first URI before the age of sixth month. Most of these risk factors for wheezing can be avoided or controlled. Prospective studies on wheezing, especially in children with a severe presentation, are needed to analyze the impact of these risk factors and the effect of preventive actions.

Epidemiological aspects of and risk factors for wheezing in the first year of life

Jornal Brasileiro de Pneumologia, 2014

OBJECTIVE: To determine, in a sample of infants, the prevalence of and risk factors for occasional wheezing (OW) and recurrent wheezing-wheezy baby syndrome (WBS). METHODS: Parents of infants (12-15 months of age) completed the International Study of Wheezing in Infants questionnaire. RESULTS: We included 1,269 infants residing in the city of Blumenau, Brazil. Of those, 715 (56.34%) had a history of wheezing, which was more common among boys. The prevalences of OW and WBS were 27.03% (n = 343) and 29.31% (n = 372), respectively. On average, the first wheezing episode occurred at 5.55 ± 2.87 months of age. Among the 715 infants with a history of wheezing, the first episode occurred within the first six months of life in 479 (66.99%), and 372 (52.03%) had had three or more episodes. Factors associated with wheezing in general were pneumonia; oral corticosteroid use; a cold; attending daycare; having a parent with asthma or allergies; mother working outside the home; male gender; no br...

Risk Factors for Recurrent Wheezing in Infants

Journal of Human Growth and Development, 2013

ResumoIntrodução: a sibilância é um dos sintomas respiratórios mais comuns na infância. Independentemente da causa, é motivo de procura por atendimento médico em serviços de urgência, sobretudo se há recorrência dos episódios. Muito frequente na infância, a sibilância de repetição tem seus primeiros episódios no primeiro ano de vida. Objetivo: verificar os fatores de risco para sibilância recorrente em lactentes no primeiro ano de vida. Método: pesquisa de campo do tipo exploratória, transversal com abordagem quantitativa, onde foi aplicado um questionário padronizado do Estudo Internacional de Sibilância em Lactentes, traduzido e validado no Brasil, constituído por questões objetivas. Foram questionadas 40 mães cadastradas em duas Unidades de Saúde da Família. Resultados: os fatores de risco encontrados: tabagismo durante a gestação, histórico familiar de asma, rinite e dermatite alérgica, presença de pelo menos um animal doméstico em domicílio na época do nascimento e idade do pri...

Prevalence of recurrent wheezing in infants

Jornal de Pediatria, 2007

Objective: To identify the prevalence of recurrent wheezing in infants in the city of Curitiba, PR, Brazil. Methods: A cross-sectional study carried out by means of administering questionnaires to the parents of infants aged 12 to 15 months attending health centers for immunization during the period between August 2005 and December 2006. This is a standardized and validated instrument consisting of questions on demographic characteristics, wheezing, respiratory infections and risk factors. At the time of the study the City Health Department had 107 health centers, 35 of which were selected by lots and distributed homogeneously across the municipal territory. Results: A total of 1,364 infants (45.4%) had episodes of wheezing during their first 12 months of life, with onset at 5.5±3.1 months (mean ± standard deviation), and 678 (22.6%) had had three or more episodes. In 84.6% of the wheezing children treatment was with β 2-agonists, with inhaled corticosteroids in 18.5%, oral corticosteroids in 24.3% and leukotriene receptor antagonists were used with 5.4%. The wheezing children exhibited nocturnal symptoms, intense difficulty breathing and visits to emergency services in the proportions of 58.9, 46.2 and 57.6%, respectively; 12.7% were admitted to hospital for asthma and 10.9% had had a medical diagnosis of asthma. Nocturnal symptoms, visits to emergency, severity of symptoms, hospital admissions for asthma and medical diagnoses of asthma were all more common among those who had suffered three or more crises (p < 0.001). Conclusions: There is an elevated prevalence of wheezing among the infants of Curitiba, with early onset and elevated morbidity. It is possible that these infants represent a large contingent of asthmatics.

Prevalence and risk factors for wheezing in Salvador, Brazil: a population-based study

QJM, 2014

Background: Wheezing is one of the most frequent causes of visit to emergency rooms among children. However, data on wheezing burden are mostly provided at healthcare setting, and particularly only for infants. Aims: We sought to estimate the prevalence of wheezing in children under 4 years and to assess potential risk factors in the community. Design: This was a cross-sectional analysis of a population-based cohort study. Methods: The sample comprised children aged <4 years living in Salvador, Brazil. Data were collected via home visits when the parents/guardians were interviewed. Data were recorded on standardized forms. Results: Of 1534 children, mean age was 21 AE 14 months (minimum 3 days; maximum 47 months; 6% <2 months); 780 (51%) were males and 501 [33%; 95% confidence interval (95% CI): 30-35%] reported wheezing in the last 12 months. Among wheezers, 321 (64%) had occasional wheezing. Overall, 180 (12%; 95% CI: 10-14%) had recurrent wheezing and 157 (10%; 95% CI: 9-12%) had asthma. For children in the first, second, third and fourth year of life wheezing was reported in 23, 41, 34 and 37%, respectively. Mother atopic-related disease was independently associated with recurrent wheezing (Adj PR[95% CI]: 1.54 [1.12-2.11]) and asthma (Adj PR[95% CI]: 1.54 [1.10-2.16]). Smoker at home (Adj PR[95% CI]: 1.34 [1.07-1.67]) and low birth weight (Adj PR[95%CI]: 1.38 [1.05-1.81]) were independently associated with occasional wheezing. Conclusions: One-third of under 4 years reported wheezing; history of mother's atopic-related disease was an independent risk factor for recurrent wheezing and asthma; smoker at home and low birth weight were independent risk factors for occasional wheezing.