Vinca alkaloid-the second most used alkaloid for Cancer Treatment-A review (original) (raw)
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Ethnopharmacological review of vinca plant for anticancer activity
Current Trends in Pharmacy and Pharmaceutical Chemistry
The strive of this assessment shows that Vinca rosea, many obviously grown vegetation round us which can be used for medicinal purposes. It has many known names like vinca Rosea, Madagascar periwinkle, vibrant eyes, Cape periwinkle, graveyard plant, old maid, crimson periwinkle, rose periwinkle myrtle. Ayurveda is the Indian conventional device of medication which focuses on the scientific capability of plant life. Catharanthus roseus is one plant recognized nicely in Ayurveda. It is known for its antitumour, anti-diabetic, anti-microbial, anti-oxidant and antimutagenic effects. It is an evergreen plant first originated from islands of Madagascar. The flowers can also range in color from red to pink and leaves are organized in opposite pairs. It produces nearly 130 alkaloids especially ajmalcine, vinceine, resperine, vincristine, vinblastine and raubasin. Vincristine and vinblastine are used for the treatment of various types of cancer such as Hodgkin’s disease, breast cancer, skin ...
Cancer therapy with Vinca Alkaloids
International Journal of Experimental Research and Review (IJERR), 2016
Vinca alkaloids are well known antimitotic or antimicrotubule agents, originally derived from the medicinal plant Catharanthus roseus (Apocynacea) and other Vinca plants. They have a wide spectrum of anticancer activity both in vitro and in vivo. The most important members of this family are vinblastine and vincristine (naturally occurring), and their semisynthetic derivatives viz., vindesine, vinorelbine, vinflunine, which were approved by FDA as drugs in cancer therapy. They are used alone or in combination with other anticancer agents for the treatment of a variety of cancers including leukemias, lymphomas, advanced testicular cancer, breast and lung cancer and kaposi's sarcoma. In this article, some cancer related relevant information of Vinca alkaloids are discussed.
Role of vinca alkaloids and their derivatives in cancer therapy
World Journal of Advanced Research and Reviews
Vinca alkaloids and its derivatives like Vincristine, Vinblastine etc. isolated from Catharanthus roseus plants are widely used in the treatment of various types of cancers. Mode of action of Vinca alkaloids (vinblastine, vincristine, vinorelbine) is microtubule-stabilizing agents (MTAs) i.e., arrest the cell cycle via disrupting microtubule dynamics. Vincristine major side effect is neurotoxicity. Hoverer, Vincristine induce neuropathy in mice or rat, used as animal model to study effect of drugs or plants by various authors also reported in review literature. Vinca alkaloids and its derivatives were widely used drugs in combination regimens with cyclophosphamide, doxorubicin, procarbazine, Methotrexate and dacarbazine etc. in various types of cancer. In this review, we also discussed major structure modifications position of chemically synthesized vincristine and vinblastine derivatives required for potential anticancer activities. Anticancer mechanism and some major patents on vi...
The phytochemical and pharmacological properties of Catharanthus roseus (Vinca)
Science progress and research, 2022
Vinca alkaloids obtained from Madagascar are a subset of drugs. Generally, they are naturally extracted from the Vinca rosea plant, Catharanthus roseus G, Don and show hyperglycemia activity as well as cytotoxic effects.In recent pharmacological studies and traditional utilization of Vinca rosea have proved the medicinal properties of the plant, and it is also continuously used to prevent various diseases. It is used to treat various diseases such as diabetes, hypertension, cancer, asthma, inflammation, malaria, angiogenesis, brain imbalance, dysentery, and is also used as a disinfectant that occurs due to potent microorganisms. The vinca alkaloids are played an essential role to fight cancer disease. There are some major vinca alkaloids in clinical use: Vinblastin, Vincristine, Vindesine, tabersonine, vinorelbine, and Vinpocetine, etc. The flowers juice of Vinca rosea is utilized to treat several skin problems e.g. acne, eczema, and dermatitis. According to our opinion that it may be help scientists, ayurvedic practitioners, pharmacognosists, botanists, researchers , and students who are active in the field of medicinal plants research.
International Academic Publishing House (IAPH), 2022
Catharanthus roseus is a widely used medicinal herb in several regions of the world. It has already gained popularity because of the discovery of numerous phytoconstituents with diverse biological properties like antioxidant, antimicrobial, antifungal, hypoglycaemic, and anticancer properties. Cancer treatments involve surgical intervention, chemotherapy, radiotherapy, as well as pharmacotherapy, among other things, that not just have a significant financial impact on the patients. Still, it also leads to chronic drug resistance in patients over time. Plant-based drugs have emerged as effective precautionary chemotherapies in both developing and advanced nations. Surprisingly, the plant-derived anticancer agent vinblastine as well as vincristine were the first phytoconstituents to be utilised for drug development. In vitro suppression of human breast cancer cell lines was successfully demonstrated by new isolated biologically active compounds from this plant, such as catharoseumine, 17-deacetoxy-cyclovinblastine etc. Furthermore, vindoline, vindolicine, vindolinine and vindolidine extracted from Catharanthus roseus plant displayed anti-diabetic or antihyperglycaemic activity in vitro. Such findings strongly suggest how this plant has become a viable source of biologically active compounds and needs to be analysed further. This article highlights the function and sources of bioactive compounds derived from Catharanthus roseus, as well as the traditional uses and characteristics of phytoconstituents of this plant. Furthermore, the potential advantages of bioactive components found in Catharanthus roseus were reviewed in order to promote their potential as therapeutics.
South African Journal of Botany, 2018
Catharanthus roseus is among the most important anticancer agents providing plants in the world. In the current study, vinca leaves were cultured on MS medium supplemented with 1.5 mg/L BAP and 1.5 mg/L 2,4D. The callus obtained was subcultured on 15 different combinations of growth hormones for 28 days. The callus extracts from different treatments were analyzed by HPLC with respect to the vincristine and vinblastine producing capacity in comparison to the wild plant. The biomass was maximized with growth hormone combinations 2,4D/NAA and IAA/NAA but the biosynthesis of alkaloids were minimized. Vincristine production was potentiated in almost all growth hormones combinations with Kin/IAA producing the highest concentration. However, vinblastine was potentiated in growth hormone combinations Kin/IAA, IAA/Gb, BAP/Gb and NAA/Gb only, with Kin/IAA showing the highest concentration of vinblastine. The main motivating result was the biosynthesis of the essential anticancer dimeric alkaloids, vincristine which was hardly detected in the wild plant and vinblastine which showed a 3.39-fold increase compared to the wild plant.
Cancer Cell International
Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as alkaloids have proven efficacy and acceptability for cancer treatment. Apropos, this review deals with a spectrum of promising alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biote...
African Journal of Traditional, Complementary and Alternative Medicines, 2010
Vinblastine and vincristine (the antileukemic agents) were isolated, in a pure form, from Catharanthus roseus L. Don., cultivated in Egypt, by several chromatographic techniques. Five modified methods for the preparation of total alkaloids were carried out. All the isolated mixtures were evaluated by HPLC and HPTLC analyses. The antineoplastic alkaloids; vinblastine and vincristine, were isolated by the use of vacuum liquid chromatographic column on silica gel : aluminium oxide (1:1) mixed bed vacuum liquid chromatography (VLC), Charcoal column, and finally purified by centrifugally accelerated radial chromatography (Chromatotrone).
Vinblastine and Vincristine anticancers compounds
Abstract:-Catharanthus roseus commonly known as evergreen herb is one of the famous medicinal herb in the field of cancer treatment. Many famous phytochemicals such as Vinblastine and Vincristine was isolated from this medicinal plant. It has many pharmacological properties such as anti-oxidant, antimicrobial, anti-diabetic; wound healing, anti-ulcer, hypotensive, anti-diarrheal, hypolidima and memory enhancement. Alkaloids are one major phytochemicals responsible for its anti cancer properties followed by phenolic compound such as flavanoid.
Issn 0189-6016©2009 Isolation and Characterization of Antineoplastic Alkaloids from
2016
Vinblastine and vincristine (the antileukemic agents) were isolated, in a pure form, from Catharanthus roseus L. Don., cultivated in Egypt, by several chromatographic techniques. Five modified methods for the preparation of total alkaloids were carried out. All the isolated mixtures were evaluated by HPLC and HPTLC analyses. The antineoplastic alkaloids; vinblastine and vincristine, were isolated by the use of vacuum liquid chromatographic column on silica gel: aluminium oxide (1:1) mixed bed vacuum liquid chromatography (VLC), Charcoal column, and finally purified by centrifugally accelerated radial chromatography (Chromatotrone).