Screening of analgesic and anti-inflammatory activities of Citrullus colocynthis from southern Tunisia (original) (raw)
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Analgesic and anti inflammatory herbs: a potential source of modern medicine.
2010
In recent time, scientific investigations of medicinal plants using indigenous medical systems has attracted a lot of attention globally. Nature has bestowed our planet with an enormous wealth of medicinal plants have been known for millennia and are highly esteemed all over the world as a rich source of therapeutic agents for the prevention and cure of diseases and ailments. Inflammation is complex biological response of vascular tissue due to different harmful stimuli and pain is discomfort signals result of actual or potential injury to the body may associate with inflammation. Inflammation with pain is associated with different diseases like rheumatism, encephalitis, pneumonia, oesophagitis, cancer, heart problems, fibrosis etc. Nonsteroidal antiinflammatory drugs and opioid analgesic are normally used in the treatment of inflammation and pain but can cause a lot of adverse effect. Therefore herbal drugs can be potential source to replace them. Every year a lot of plants form traditional medicinal system has been screened for their potential antiinflammatory and analgesic activity but only few of them only included in health care system after clinical research. So this is time to give more emphasis on research work based on natural sources, investigate the active phytoconstituents, use them on specific treatment, find out adverse effect and to work towards tapping their therapeutic utility.
Planta Medica, 1990
Ethanolic and aqueous extracts from seven plant species used in Turkish traditional medicine were evaluated for in vivo anti-inflammatory and antinociceptive activities; Helleborus orientalis Lam. roots and herbs, Juglans regia L. leaves, Laurocerasus officinalis Roemer leaves, Nerium oleander L. dried and fresh flowers and leaves, Rhododendron ponticum L. leaves, Rubus hirtus Walds. et Kit aerial parts and Rubus sanctus Schreber aerial parts and roots. All the plant extracts, except the aqueous extract of Rubus hirtus, were shown to possess significant antinociceptive activity in varying degrees against p-benzoquinone-induced abdominal contractions in mice. However, only the ethanolic extracts of Helleborus orientalis roots, Juglans regia leaves, Laurocerasus officinalis leaves, Nerium oleander dried and fresh flowers, and Rhododendron ponticum leaves exhibited potent anti-inflammatory activity against carrageenan-induced hind paw edema model in mice without inducing any gastric damage. Results of the present study confirmed the folkloric claim that all the selected materials to possess potent antinociceptive and anti-inflammatory activity.
Almost all diseases are associated with the inflammation and pain. The Present study was designed to evaluate analgesic and anti inflammatory potentialities of methanolic extract of Cirtrullus lanatus rind which belongs to Cucurbitaceae family. Potent analgesic activity was observed (p<0.05) in extract 400mg/kg by 66.45% inhibition of writhing reflex and mild (50.63% inhibition) activity was observed in 200mg/kg compare to inhibition of 82.91% of standard Diclofenac 10 mg/kg. On the other hand, anti-inflammatory effect was remarkable (p<0.05) with 400mg crude compare with Standard Diclofenac 5 mg/kg body weight. Dunet test represents 46% reduction of paw edema compare to standard of 56.71%. Preliminary phytochemical screening of the plant extract showed the presence of Glycosides, saponins, flavonoids, steroids and protein were present in the rind of Citrullus lanatus one of which has analgesic, anti inflammatory properties. These provide scientific evidence to support the isolation and development of biologically active components as analgesic and anti-inflammatory agents.
International Journal of Green Pharmacy, 2016
The present review explains reasons of arthritis a disease related to chronic joint pain and inflammation. It also emphasizes the use of bioactive principles of plant origin to be used to relieve from arthritic pain, aching, stiffness, and swelling. These plant natural products can finish rheumatic pain if they are used regularly according to physician’ advice. There are so many active crude extracts and pure compounds which show anti-arthritic activity in Freund’s complete adjuvant induced animal models. Certain Ayurvedic formulations also assist to relieve from rheumatic arthritic pain and tone up immune system to function normally. This article shows an overview of medicinal suggestions on the basis of experimental advances made in the herbal medicinal researches in recent years for the treatment of arthritis. There are various dietary supplements which could also provide for management of severe pain of joints, and mitigation of inflammation. It is also suggested that early diag...
2014
Background: Cnidoscolus quercifolius is a species popularly known as "favela" and "faveleira", and belonging to the Caatinga biome (semi-arid vegetation, Brazil), where is used in folk medicine as an anti-inflammatory. Objective: The aim was to evaluate the anti-inflammatory effect of the ethanolic extract from barks (Cqb-EtOH) and leaves (Cql-EtOH) of C. quercifolius in mice using experimental models of inflammation. Materials and Methods: The preliminary phytochemical analysis of the ethanolic extract was performed. The activity was evaluated by paw edema induced by carrageenan and leukocytes migration to the peritoneal cavity induced by carrageenan methods. Results: A preliminary analysis of Cqb-EtOH revealed that it contained coumarins, flavonoids, monoterpenes/diterpenes and naphthoquinones, while the Cql-EtOH showed positive reaction to coumarins, anthracene derivatives, flavonoids, lignans and triterpenes/steroids. Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited significantly (P < 0.01) the increase in the edema volume after administration of carrageenan. In the peritonitis test, acute pretreatment with Cqb-EtOH and Cql-EtOH (100, 200 and 400 mg/kg) inhibited the leukocyte migration. Conclusions: It can be concluded that extracts from the barks and leaves of C. quercifolius have anti-inflammatory activity, which supports the popular use of this plant to treat inflammation. Thus, extracts has significant anti-inflammatory properties, which are related probably to inhibition of release of mediators of the inflammatory process.
Ethnomedicinal plants as antiinflammatory and analgesic agents
Ethnomedicine: A Source of Complementary Therapeutics, 2010
The use of traditional medicine is expanding to newer horizons and plants still remain as the novel source of structurally important compounds that lead to the development of innovative drugs. India has about 45,000 plant species among which medicinal property has been attributed to several thousands. The traditional Indian system of medicine, the Ayurveda, mentions the use of plants in the treatment of various diseased conditions. Ethnobotanical research done in last few decades have revealed the anti-inflammatory and analgesic properties of plants cited in the traditional literature. Many herbal preparations are being prescribed as anti-inflammatory and analgesic in the traditional literature. The search for new anti-inflammatory and analgesic agents from the huge array of medicinal plant resources is intensifying. This is because such taxa may hold assurance for the discovery of novel therapeutic agents capable of suppressing, reducing or relieving pain as well as inflammation. This chapter reviews such plant species and their products that have shown experimental or clinical anti-inflammatory or analgesic activities,
The purpose of this investigation was to elucidate the anti-nociceptive and anti-inflammatory properties of aqueous acetone extracts from Cienfuegosia digitata Cav; and Sida Alba L. in Swiss mice, with an aim to provide a scientific basis for the traditional use of these plants in the treatment of inflammation disorders. In antiinflammatory activity, the carrageenan-induced paw edema and oil croton-induced ear edema in Swiss mice. As for analgesic effects, acetic acid writhing and formalin test methods were used in mice. About anti-inflammatory potential, the extracts at doses of 100; 200 and 400 mg/kg body weight produced significant comparatively to the control groups (p<0.05; p<0.01 and p<0.001) and we noticed a dose-dependent anti-inflammatory activity. The dose-dependent inhibition of edema was observed at 1; 2 and 3 h. However, extracts showed dose-dependent inhibition of croton oil induced ear oedema, at doses of 200; 300 and 500 µg/ear. As for analgesic activity, extracts produced significant analgesic effects in acetic acid writhing and formalin test method (p<0.05; p<0.01 and p<0.001) compared to the control groups and a dose-dependent inhibition was observed. The present study concludes that Cienfuegosia digitata Cav. and Sida Alba L. have anti-inflammatory and analgesic properties.
Study of a Standardized Plant Extract Used as an Anti-Inflammatory Drug to Reduce Joint Pain
Revista De Chimie, 2020
This study was to demonstrate the role of a natural anti-inflammatory, in reducing pain, inflammatory process and increasing joint mobility in elderly patients diagnosed with knee osteoarthritis. Osteoarthritis off knee affect the articular cartilage, but also the articular capsule, leading to disability. This natural anti-inflammatory has a complex composition: extract de Boswellia serrata 300 mg, extract de curcuma 100 mg, extract Pinus pinaster 80 mg și extract de Zingiber officinale 40 mg. The combination of herbal products, which have no side effects, with electrotherapy and kinetotherapy can be a real success in this category of patients, also influencing their well-being.
Plants and Plant Constituents with Analgesic and Anti-inflammatory Activities: A Systematic Review
Dhaka University Journal of Pharmaceutical Sciences
Medicinal plants with potential therapeutic activities are a tremendous resources of prospective drug candidates. NSAIDs, opiates, and other anti-inflammatory & analgesic agents exhibit several unwanted side-effects. Thus, the development of new active compounds with minimum adverse effects necessitates an emergence. This study aims to provide a comprehensive summary of plant species and reported phytoconstituents with analgesic and inti-inflammatory activities. Eighty-seven species from fifty-two plant families with reported constituents and activities have been included in this review. In-depth research in the area of screening novel analgesic and antiinflammatory agents from natural sources followed by the investigation of their pharmacological properties and clinical applications may lead to the generation of new active agents with better therapeutic activity and selectivity in the future. Dhaka Univ. J. Pharm. Sci. 19(2): 207-224, 2020 (December)
ANTI-INFLAMMATORY ACTIVITY OF THE PLANTS USED IN TRADITIONAL MEDICINES
Herbal medicines have great importance in maintaining the health of the individual. Demand for medicinal plant is increasing in both developed and developing countries due to growing recognition of natural plant being non narcotic, having no side effect, easy availability in surrounding area at desired price. Different parts of the plant have different active substances and these active substances may vary in their extent of activity and concentration. Most of active principles are present in leaves, flower, fruit, bark, root & seeds of the plant. Inflammatory diseases are a major and worldwide problem. Gastrointestinal side effect is the major problem associated with the presently available non-steroidal anti-inflammatory agents. In this review we have described some medicinal plants with respect to their anti-inflammatory action.