P0595 CABERGOLINE AND CARDIAC VALVULOPATHY – A UNIT REVIEW (original) (raw)

2009, European Journal of Internal Medicine

Introduction: Growth hormone (GH) deficiency results in postprandial hyperlipidemia wich can be corrected by GH suppletion. It is unknown if GH activity affects postprandial lipemia in subjects with normal GH levels. Objectives: To evaluate the relationship between IGF1 concentrations and postprandial lipemia in subjects with normal GH production. Materials and methods: 158 subjects with a normal IGF1 levels (219,2±90,9 ng/mL; x±SD) measured their daytime capillary triglycerides (cTG) during three days in order to construct daytime TG profiles representing postprandial lipemia in a real life, physiological situation. The area under the curve (AUC) was used as total daytime triglyceridemia. Participants kept nutrition diaries, fasting venous plasma samples were obtained once and body composition was measured by body impedance. Results: The association between IGF1 and postprandial lipemia estimated as cTG-AUC after correction of fasting cTG was weak (Pearson's r=0,20; P=0,02). In contrast, fasting plasma GH levels were significantly associated to cTG-AUC (r=-0,42, P<0.001). The subjects in the highest IGF1 50-percentile had a mean±SD IGF1 of 290,2±80,7 ng/mL, were younger (30,8±12,4 yrs old) and showed the highest postprandial triglyceridemia corrected for fasting TG 16±5,10 mM.h) compared to those in the lower IGF1 percentile (44,7±12,8 yrs [P<0.001], 158,2±41,4 ng/mL [P<0.001] and 4,32±4,70 mM.h [P=0 ,02], respectively). There were no differences in insulin sensitivity between the groups by HOMA ratio, neither did fasting capillary TG differ between the groups. The major determinat of IGF1 was age (r=-0.68; P<0.001) followed by fasting plasma glucose (r=-0,43; P<0.001). Parameters related to insulin sensitivity, showed only weak correlations with postprandial lipemia, but body composition was closely associated to cTG-AUC with relative fat mass as an important determinant (r=0,41, P<0.001). Conclusion: GH activity on the long term does not affect postprandial lipemia in a real life situation in GH sufficient subjects. Body composition seems to be a major determinant of daytime TG profiles in subjects with normal GH production.