Studying Characterization of Some New Heterocyclic Derivatives that Synthesized from 2-Aminobenzothiazole Derivatives (original) (raw)
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Caspian Journal of Environmental Sciences, 2024
This work involved two parts: the first part included synthesis of new Schiff bases from condensation of 2-aminobenzothiazole with different aldehydes in acidic medium, while and the second part included the synthesis of Oxazolidinones from reaction of the prepared Schiff bases with glycine to produce new heterocyclic. Compounds. The structure of prepared compounds were characterized by 1H-NMR, FT-IR techniques and their biological activity was assessed.
Rafidain Journal of Science
Starting from benzimidazole moiety, several heterocyclic compounds (1,3-Oxazepine, thiazolidin-4one, azetidin-2-one) were synthesized, thus the Ethyl Benzimidazole acetate (1) was synthesized from the reaction of benzimidazole with ethylchloroacetate on treatment with hydrazine hydrate is giving the corresponding hydrazide (2). The reaction of this hydrazide with, 4-substituted acetophenone afforded hydrazones which on reaction with some reagents to produce synthesized compounds, (4a-c), (5a-c), (6a-c), (7a-c), (8a-c) and (9a-c). All the synthesized products were confirmed by physical and spectral methods.
Synthesis and Pharmacological Evaluation of 6-SUBSTITUTED 2-AMINOBENZOTHIAZOLES
International research journal of pharmacy, 2018
Heterocyclic compounds and analogues have attracted strong interest due to their biological and pharmacological properties. Nitrogen containing heterocyclics, Benzothiazoles are an important class of heterocyclic compounds and the nucleus containing compounds involved in research aimed at evaluating new products that possess biological activities such as antibacterial, antifungal, anthelmintic, antidiabetic, and anticancer agents. In the present study various derivatives of 6-substituted 2-aminobenzothiazoles were prepared and evaluated for their antibacterial, antifungal, antioxidant and cytotoxic activity by various standard methods. Among the synthesized compounds, most of the compounds exhibited potent activity when compared with that of the standard drugs. Hence the versatile synthetic applicability and biological activity of these heterocyclic compounds will help the chemist to plan, organize and implement new approaches towards discovery of novel derivatives of Benzothiazoles.
Monatshefte für Chemie - Chemical Monthly, 2008
A series of new N-and S-substituted 1,3,4-oxadiazole derivatives were synthesized. 5-Pyridin-3-yl-3-[2-(5-thioxo-4,5-dihydro-l,3,4-thiadiazol-2-yl)ethyl]-1,3,4-oxadiazole-2(3H)-thione and 5-[(5-(pyridin-3-yl)-1,3,4-oxadiazol-2-ylthio)methyl]-Nphenyl-1,3,4-thiadiazol-2-amine were formed by cyclization of 3-(5-pyridin-3-yl-2-thioxo-1,3,4-oxadiazol-3(2H)-ylpropanimidohydrazide and 2-[(5-pyridin-3-yl-1,3,4-oxadiazol-2-yl)thio]thiosemicarbazide with CS 2 and H 2 SO 4 . On the other hand, a number of new bicyclic 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were synthesized. 6-Pyridin-3-ylbis[1,2,4]triazolo[3,4-b:4 0 ,3 0 -d][1,3,4]thiadiazole-3(2H)-thione was synthesized by reaction of 6-(hydrazino)-3-pyridine-3-yl[1,2,4]triazolo [3,4-b][1,3,4]thiadiazole with CS 2 =KOH=EtOH. The structures of the newly synthesized compounds were elucidated by the spectral and analytical data IR, Mass, and 1 H NMR spectra.
Preparation and Characterization of some new Benzothiazole-Heterocyclic Derivatives
Egyptian Journal of Chemistry
In this work new different hetero cyclic derivatives were synthesized that which including β-Lactam, teterazole and also thiazole rings.The starting material is 2-amino-6-methoxy-Benzothiazole. All these reactions follow by (TLC) and Measurement melting points for some of these derivatives. The compounds identified by FT-IR and some of them by 1H-NMR and 13C-NMR spectra., The prepared benzothiazole derivatives in this study gave good results through appearance of new bands and disapearance of other bands in formatted compounds that gave first data to formation benzothiazole derivative , while second technique represented by resonance spectra that gave also good results for formatted benzothiazole derivative.m in addition to flowing of all reactions by paper chromatography.
Monatshefte für Chemie - Chemical Monthly, 2007
3-(3-Methylthiazolo[3,2-a]benzimidazol-2-yl)-3oxopropionitrile was synthesized by refluxing ethyl 3-methylthiazolo[3,2-a]benzimidazole-2-carboxylate, acetonitrile, and sodium hydride. Treatment of 3-(3-methylthiazolo[3,2a]benzimidazol-2-yl)-3-oxopropionitrile with phenyl isothiocyanate, in the presence of KOH, furnished the corresponding potassium salt which was converted into thioacetanilide derivative upon neutralization. The thioacetanilide derivative reacts with-chloroacetylacetone and ethyl-chloroacetoacetate to give the 1,3-thiazole derivatives, while the reaction of the thioacetanilide derivative with hydrazonyl chlorides gave 1,3,4-thiadiazole derivatives. On the other hand, 3-(3methylthiazolo[3,2-a]benzimidazol-2-yl)-3-oxopropionitrile reacted with the diazonium salt of both 3-phenyl-5-amino-(1H)-pyrazole and 5-amino-l,2,4-(1H)-triazole to afford the corresponding hydrazones. The latter hydrazones underwent an intramolecular cyclization upon boiling in pyridine to give pyrazolo[5,1-c]-1,2,4-triazine and 1,2,4-triazolo[5,1-c]-1,2,4triazine derivatives. Moreover, the behavior of thiazolo[3,2a]benzimidazol-3(2H)-one towards phenyl isothiocyanate followed by the reaction with-chloroketones or hydrazonyl chlorides was investigated. Some of the latter compounds exhibited moderate effects against some bacterial and fungal species.