Primary Pancreatic Lymphoma Presenting as Gastric Fistula: A Case Report (original) (raw)
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Primary Gastric Lymphoma Presenting as Acute Pancreatitis: A Case Report
JOP : Journal of the pancreas, 2013
Diffuse large B-cell lymphoma is the commonest form of non-Hodgkin lymphoma. Gastro-intestinal tract and bone marrow are common extra-nodal sites of lymphomatous involvement. A 54-year-old woman presented with acute onset epigastric pain. On evaluation, raised serum amylase and radiological features of acute pancreatitis were detected. Gastroscopy revealed thickened folds in distal stomach, which on histopathology revealed large B-cell lymphoma. Subsequently, the patient developed extra-hepatic biliary obstruction due to peripancreatic lymph nodal mass that was relieved with plastic biliary stenting. Subsequent chemotherapy regime directed against lymphoma led to resolution of lymphoma. In this patient , pancreatitis was the initial presentation of primary gastric lymphoma, which has not been commonly reported and therefore should be considered in the etiological workup.
Primary Pancreatic lymphoma: a rare clinical entity
BMJ Case Reports
Primary pancreatic lymphoma is a rare clinical entity representing <0.5% of pancreatic cancers and 1% of extranodal lymphomas. Due to the paucity of cases described in the literature, its clinicopathological features, differential diagnosis, optimal therapy and outcomes are not well defined. As the clinical manifestations are often non-specific, it can create a diagnostic pitfall for the unwary physician. Preoperative distinction of adenocarcinoma and primary pancreatic lymphoma is critical since the management and prognosis of these malignancies are mutually exclusive. Due to its rarity, epidemiological studies have been difficult to conduct. Chemotherapy with R-CHOP (rituximab, cyclophosphamide, doxorubicin and vincristine) has proven to be effective. The authors present the case of a 52-year-old man with epigastric pain and obstructive jaundice. Further investigation with a CT of the abdomen and pelvis showed a low attenuation mass in the head of the pancreas measuring 35×25 m...
Primary pancreatic lymphoma: A rare cause of pancreatic mass
Oncology Letters, 2015
Primary pancreatic lymphoma (PPL) is a rare entity, most likely to be clinically misdiagnosed as pancreatic cancer. The cure rate of PPL is higher compared with that of pancreatic adenocarcinoma. This is the case report of a 57-year-old male patient who was hospitalized with complaints of abdominal pain, weight loss and jaundice. The radiological evaluation revealed a pancreatic head mass and, following endoscopic ultrasound-guided fine-needle aspiration biopsy, the tumor was diagnosed as diffuse large B-cell lymphoma. The final diagnosis was PPL, and the patient went into remission after receiving three cycles of treatment with rituximab, doxorubicin, cyclophosphamide, vincristine and prednisolone (R-CHOP regimen). Therefore, PPL should be considered in the differential diagnosis of pancreatic masses and its management differs from that of other types of pancreatic tumor.
BMC cancer, 2006
Primary pancreatic lymphomas (PPL) are rare tumours of the pancreas. Symptoms, imaging and tumour markers can mimic pancreatic adenocarcinoma, but they are much more amenable to treatment. Treatment for PPL remains controversial, particularly the role of surgical resection. Four cases of primary pancreatic lymphoma were identified at Prince of Wales Hospital, Sydney, Australia. A literature review of cases of PPL reported between 1985 and 2005 was conducted, and outcomes were contrasted. All four patients presented with upper abdominal symptoms associated with weight loss. One case was diagnosed without surgery. No patients underwent pancreatectomy. All patients were treated with chemotherapy and radiotherapy, and two of four patients received rituximab. One patient died at 32 months. Three patients are disease free at 15, 25 and 64 months, one after successful retreatment. Literature review identified a further 103 patients in 11 case series. Outcomes in our series and other series...
An Atypical Case of Primary Gastric Lymphoma
Scholars Journal of Medical Case Reports, 2016
We report a case of a fifty-two-year old gentleman who presented with a history of early satiety after meals altered bowel habits for 1 month and fever for 2 weeks. On local examination, an intra-abdominal, non-tender, variegated swelling was found extending from left hypochondrium to the epigastric region. Contrast enhanced CT scan showed a heterogeneous mass (11 cm x 11 cm) at left upper quadrant, medial to spleen, compressing the stomach, ?Neoplastic lesion. Exploratory laparotomy found a huge irregular mass involving spleen, tail of pancreas, gerota's fascia and greater curvature of stomach, having adhesion with diaphragm and omentum, but without any enlarged lymph nodes. En-bloc excision of mass along with spleen, tail of pancreas, and a sleeve of stomach including the greater curvature was preformed. Subsequently, histopathology and immunohistochemistry confirmed it to be a case of Diffuse Large B-Cell Lymphoma of stomach (DLBCL).The rarity of the diagnosis along with its nature of presentation, and absence of several characteristic features make this case an interesting one.