Influence of respiratory function parameters on the quality of life of COPD patients* Influência dos parâmetros funcionais respiratórios na qualidade de vida de pacientes com DPOC (original) (raw)
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Jornal Brasileiro de Pneumologia, 2008
OBJETIVO: Verificar a validade e a reprodutibilidade do uso de dois instrumentos subjetivos para avaliar a limitação nas atividades da vida diária (AVD) em pacientes com doença pulmonar obstrutiva crônica (DPOC) no Brasil: o Pulmonary Functional Status and Dyspnea Questionnaire - Modified version (PFSDQ-M) e a escala do Medical Research Council (MRC). MÉTODOS: Trinta pacientes com DPOC (17 homens; idade, 67 ± 10 anos; volume expiratório forçado no primeiro segundo, 42% ± 13% do predito) responderam por duas vezes às versões em português dos dois instrumentos com intervalo de uma semana. O PFSDQ-M contém três componentes: influência da dispnéia nas AVD, influência da fadiga nas AVD, e mudança nas AVD em comparação ao período anterior à doença. A escala do MRC é simples, com apenas cinco itens, dentre os quais o paciente escolhe qual o seu nível de limitação nas AVD devido à dispnéia. O tradicional questionário Saint George's Respiratory Questionnaire (SGRQ), já validado para o us...
What predicts quality of life in elderly patients with COPD?
The European respiratory journal. Supplement
The aim of this study was to assess whether frequency of bronchiectasis in patients with COPD had any impact on quality of life. Study include 62 patients (mean age 59.2 years) with clinically stable COPD. Pulmonary function tests, arterial blood gases, dyspnea measurements using Modified Medical Research Council Dyspnea Scale (MMRC) were assessed. Quality of life was measured by St. George's Respiratory Questionnaire (SGRQ). To assess the presence and extension of bronchiectasis, the modified Bhalla score was used. HRCT revealed that 58% of patients with COPD had bronchiectasis and extension of bronchiectasis was more in lower lobes (58.3%). There were significant difference with daily sputum production (p=0.004) and borderline difference in effect score of SGRQ quality of life (p=0.05) between patients with COPD plus bronchiectasis and COPD. According to multiple linear regression analyse when effect of age and sex adjusted stage of disease (beta= 0.59, p=0.0001, r2=0.50), smoking pack years (beta= 0.30, p=0.01, r2=0.50), duration of disease (beta= 0.32, p= 0.02, r2=0.18), presence of bronchiectasis (beta= 0.26, p=0.03, r2=0.16), degree of bronchial dilatation (beta= 0.24, p=0.05, r2=0.16), tickness of bronchial wall (beta= 0.28, p=0.03, r2=0.17), arterial PaO 2 (beta= -0.43, p=0.008, r2=0.22), DLCO% (beta= -0.40, p=0.007, r2=0.23) ve and MMRC (beta= 0.71, p=0.0001, r2=0.50) were detected as significant predictors of total score of quality of life. Bronchiectasis is frequently encountered in patients with COPD, and quality of life is negatively effected by this condition. Presence of bronchiectasis in patients with COPD should be taken into consideration on clinical assesments.
Revista Portuguesa de Pneumologia, 2010
R e v i s t a P o r t u g u e s a d e P n e u m o l o g i a 543 Vol XVI N.º 4 Julho/Agosto 2010 Artigo Original Original Article Resumo Objectivos: Comparar os efeitos da asma e da DPOC na qualidade de vida dos doentes avaliados pelo Saint George Respiratory Questionnaire (SGRQ) através de correlações entre as variáveis e os domínios e a pontuação total. Métodos: Estudo transversal entre Outubro de 2008 a Março de 2009 com 75 adultos das consultas de ambulatório do Hospital Universitário de Salamanca, Espanha. Depois de informar os objectivos do estudo e os aspectos éticos, foi preenchido um formulário com os dados clínicos e socio-Abstract Aims: To compare the effects of asthma and chronic obstructive pulmonary disease (COPD) on the quality of life of patients evaluated using the Saint George Respiratory Questionnaire (SGRQ) through correlating the variables, domains and total score. Methods: A cross-sectional study from October 2008 to March 2009 with 75 adult outpatients at the University Hospital of Salamanca, Spain. Patients provided their clinical and socio-demographical data after being informed of the study's aims and ethical aspects. The A qualidade de vida relacionada com a saúde de doentes com doença pulmonar obstrutiva crónica e asma avaliada pelo SGRQ The health-related quality of life of patients with chronic obstructive pulmonary disease and asthma evaluated by the SGRQ Recebido para publicação/received for publication: 09.10.29 Aceite para publicação/accepted for
Respiratory Medicine: COPD Update, 2006
Background: COPD is currently the fourth cause of morbidity and mortality in the developed world. Patients with COPD experience a progressive deterioration and disability, which lead to a worsening in their healthrelated quality of life (HRQoL). The aim of this work is to assess the Health-Related Quality of Life (HRQoL) of patients with stable COPD followed in primary care and to identify possible predictors of disease. Methods: It is a multicenter, epidemiological, observational, descriptive study. Subjects of both sexes, older than 40 years and diagnosed of COPD at least 12 months before starting the study were included. Sociodemographic data, severity of disease, comorbidity, and use of health resources in the previous 12 months were collected. All patients were administered a generic quality-of-life questionnaire, the SF-12, that enables to calculate two scores, the physical (PCS-12) and the mental (MCS-12) component summary scores. Results: 10,711 patients were evaluated (75.6% men, 24.4% women), with a mean age of 67.1 years (SD 9.66). The mean value of FEV 1 was 35.9 ± 10.0%. Mean PCS-12 and MCS-12 scores were 36.0 ± 9.9 and 48.3 ± 10.9, respectively. Compared to the reference population, patients with COPD had a reduction of PCS-12, even in mild stages of the disease. The correlation with FEV 1 was higher for PCS-12 (r = 0.38) than for MCS-12 (r = 0.12). Predictors for both HRQoL components were sex, FEV 1 , use of oxygen therapy, and number of visits to emergency rooms and hospital admissions. Other independent predictors of PCS-12 were age, body mass index and educational level. Conclusion: Patients with stable COPD show a reduction of their HRQoL, even in mild stages of the disease. The factors determining the HRQoL include sex, FEV 1 , use of oxygen therapy, and number of visits to emergency rooms and hospital admissions.
Evaluation of the quality of life with COPD Assessment Test
The European respiratory journal. Supplement
Background: COPD Assessment Test (CAT) is a short, simple questionnaire for assessing and monitoring chronic obstructive pulmonary disease (COPD) patients. It was demonstrated that it has good measurement properties, is sensitive to dif-ferences in state and should provide a valid, reliable and standardised measure of COPD health status. The aim of this study was to investigate the factors that can predict HRQL in patients with COPD. Methods: 60 consecutive COPD patients were enrolled into the study. We an-alyzed age, gender, anthropometric, pack years, spirometric data (FEV1, FVC, FEV1/FVC), BODE index (BMI, FEV1, MRC, 6 MWD). Health-related quality of life was assessed by the CAT and the St. George Respiratory Questionnaire (SGRQ). Results: 60 COPD patients were studied, mean age was 60.2±7.5 years, mean FEV1, % was 34.6±11.3%. Patients across all stages GOLD/ATS/ERS classifi-cation had similar age and pack/years (p>0.01). Pearson correlation coefficient analysis demonstrates in ...
Jornal Brasileiro de Pneumologia, 2006
Objective: The objective of this study was to evaluate the applicability of a modified version of the Saint George's Respiratory Questionnaire. The version evaluated elicits "agree" and "do not agree", rather than "yes" and "no", responses. The intention is to facilitate the comprehension of double-negative questions and to promote better recollection of symptoms by patients by shortening their symptom histories from 12 months to 3 months. Methods: A total of 30 clinically stable patients with chronic obstructive pulmonary disease were evaluated. The Saint George's Respiratory Questionnaire and the modified version of the same were administered 15 days apart. Results: All of the patients presented health-related alterations in their quality of life. Comparing mean scores between the two questionnaires, the greatest difference was seen in the Symptoms domain. No significant differences were found in any of the remaining domains or in the total scores. In a subsequent analysis, significant correlations between the two questionnaires were found in all domains: Symptoms (r = 0.71; p < 0.001); Activity (r = 0.75; p < 0.001); Impact (r = 0.73; p < 0.001) and
Quality of Life Research, 2015
Objective To assess the validity and reliability of the chronic respiratory questionnaire (CRQ) in the measurement of HRQL in the Colombian population with COPD. Study design and setting A cross-sectional study was conducted with a sample of 200 patients diagnosed with COPD according to GOLD criteria. Convergence validity was evaluated by correlating the questionnaire results with other clinical variables such as exercise tolerance, forced expiratory volume at the first second (FEV1), and depression levels. Results HRQL measured through the CRQ correlated significantly with the 6-min walk test (r = 0.34), just as the dimensions fatigue (r = 0.37) and dyspnoea correlated with the FEV1 test (r = 0.21) and the dimensions emotional function and disease management with depression levels (r =-0.79). The Generalized Structured Component Analysis (GSCA) with the prespecified model is showed, and the total variance explained by the items in the model was 61.5 % (FIT = 0.615), unweighted least squares (GFI = 0.998), and standardised root mean square (SRMR = 0.084), indicating that the model fits adequately. Conclusion The CRQ presents evidence of adequate validity and reliability in the Colombian population. Its use is recommended to measure HRQL in patients with COPD, although future validations will be needed to identify the property of sensitivity to change.
Journal of Clinical Epidemiology, 1998
The aim of this article is to evaluate the measurement properties of the Spanish version of the SF-36 Health Survey . In total, 321 male chronic obstructive pulmonary disease (COPD) patients attending hospital outpatient or primary health clinics were cross-sectionally administered the SF-36, the St. George's Respiratory Questionnaire (SGRQ), and a dyspnea scale. A clinical measure of respiratory function, the proportion of the predicted Forced Expiratory Volume in 1 second (%FEV 1 ) was also obtained. Internal consistency, central tendency, and dispersion statistics of scores were calculated, as well as the percentage of respondents with the highest and lowest scores for each scale and correlations between health status and clinical measures. All patients completed the SF-36 questionnaire, and less than 1% of items were missing. The proportion of patients with the worst possible score (floor effect) ranged from 0.9-20.1% among the different scales. The proportion of patients achieving the best possible score (ceiling effect) ranged from 0-61%. Cronbach's alpha coefficients were above 0.75 except for one scale (Social Functioning, alpha ϭ 0.55). SF-36 scores were moderate to highly correlated with SGRQ scores (coefficients ranged from Ϫ .41 to Ϫ .79). Correlations were moderate to high with dyspnea and lower but statistically significant with %FEV 1 . A clear gradient of SF-36 scores was found according to dyspnea levels and disease staging based on %FEV 1 impairment, the gradient being more marked for the Physical Functioning, Role-Physical, and General Health scales. Data presented suggest that the Spanish version of the SF-36 is acceptable, valid, and reliable in COPD patients. Although more studies are needed, this version is adequate in international comparisons of health outcomes.