Deficient EBV-Specific B- and T-Cell Response in Patients with Chronic Fatigue Syndrome (original) (raw)

Chronic fatigue syndrome and chronic EBV infection: a long-term challenge in a single clinical case

— Background: Chronic Fatigue Syndrome (CFS) is a complex illness with different clinical definition, etio-logical models and treatments. A lot of studies have focused on the concomitance with herpesviridae infections , especially Epstein-Barr Virus (EBV). We report a clinical case highlighting the correlation between chronic EBV infection and CFS. — Results: The patient met the CDC criteria for the diagnosis of CFS and presented a high level of EBV-DNA in blood. — Conclusions: Although some studies suggest that subjects with viral infections are not more likely to develop CFS than controls, the possible connection between EBV and CFS remains unclear. EBV-DNA shows the presence of an actively replicating virus, which is known to be associated with several cancers. Whether its replication is the cause or the consequence of CSF needs further investigations.

A Comparison of Immune Functionality in Viral versus Non-Viral CFS Subtypes

Journal of behavioral and neuroscience research, 2010

Participants with CFS were grouped into viral and non-viral onset fatigue categories and assessed for differential immunological marker expression. Peripheral Blood Mononuclear Cells were assessed for differential phenotypic expression of surface adherence glycoproteins on circulating lymphocytes. The flow cytometric analysis employed fluorescent monoclonal antibody labeling. The viral in comparison to the non-viral group demonstrated significant elevations in several Th1 type subsets including: the percentage and number of CD4+ cells, the percentage and number of CD2+CD26+ cells, the percentage and number of CD2+CD4+CD26+ cells, the percentage and number of CD4+ CD26+ cells, and the percentage of Th2 naïve cells (CD4+ CD45RA+CD62L+). Of the remaining significant findings, the non viral group demonstrated significant elevations in comparison to the viral group for the following Th1 type subsets: the percentage of CD8+ cells, the percentage of T-cytotoxic suppressor cells (CD3+8+), a...