The public–private structure of intellectual property ownership in agricultural biotechnology (original) (raw)
Abstract
AI
This paper examines the evolving structure of intellectual property (IP) ownership in agricultural biotechnology, highlighting the shift from public-sector innovation to a more privatized model driven by advancements in molecular genetics. The introduction of robust IP rights has transformed crop research dynamics, enabling collaborations between public institutions and private companies, yet it has also led to an 'anticommons' situation that creates economic inefficiencies and obstacles in the development of new technologies. The paper presents a detailed analysis of patent ownership across various key technologies, underscoring the complexities introduced by multiple stakeholders in the innovation process.
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References (53)
- Evenson, R.E. & Gollin, D. (eds.). Crop Variety Improvement and Its Effect on Productivity: The Impact of International Research (CAB International, Wallingford, UK, 2002).
- Alston, J.M., Pardey, P.G. & Taylor, M.J. (eds.). Agricultural Science Policy: Changing Global Agendas (Johns Hopkins University Press, Baltimore, 2001).
- Goss, P.J. Guiding the hand that feeds: toward socially optimal appropriability in agricultural biotechnology innovation. Californian Law Rev. 84, 1395-1436 (1996).
- Graff, G., Heiman, A. & Zilberman, D. University research and offices of technology transfer. Californian Mgt. Rev. 45, 88-115 (2002).
- Wright, B.D. Public germplasm development at a crossroads: biotechnology and intellectual property. Californian Agric. 52, 8-13 (1998).
- Heller, M.A. & Eisenberg, R.S. Can patents deter innovation? The anticommons in biomedical research. Science 280, 698-701 (1998).
- Kryder, R.D., Kowalski, S.P., & Krattiger, A.F. The Intellectual and Technical Property Components of Pro-vitamin A Rice (GoldenRice): A Preliminary Freedom-to-operate Review (Brief No. 20, ISSAA: Ithaca, New York, USA, 2000).
- Hall, B.H., Jaffe, A.B. & Tratjenberg, M. The NBER patent citations data file: lessons, insights, and methodological tools. National Bureau of Economic Research, Working Paper 8498 (National Bureau of Economic Research, Cambridge, Massachusetts, USA, 2001).
- Fuglie, K.O. & Schimmelpfennig, D.E. (eds.). Public-Private Collaboration in Agricultural Research: New Institutional Arrangements and Economic Implications (Iowa State University Press, Ames, Iowa, USA, 2000).
- Hicks, D. & Narin, F. Strategic research alliances and 360 degree bibliometric indicators in Strategic Research Partnerships. National Science Foundation Workshop Proceedings, NSF 01-336 (Jankowski, J., Link, A. & Vonortas, N., eds.) 133-145 (National Science Foundation, Washington, DC, USA, 2001).
- Herrera-Estrella, L., Depicker, A., Van Montagu, M. & Schell, J. Expression of chimeric genes transferred into plant cells using a Ti plasmid-derived vector. Nature 303, 209-211 (1983).
- Klein, T.M., Wolf, E.D., Wu, R. & Sanford, J.C. High velocity microprojectiles for delivering nucleic acids into living cells. Nature 327, 70-73 (1987).
- Barton, K.A., Binns, A.N., Chilton, M.-D.M. & Matzke, A.J.M. Regeneration of plants containing genetically engineered T-DNA. US Patent 6,051,757 (2000).
- Sanford, J.C., Wolf, E.D. & Allen, N.K. Method for transporting substances into living cells and tissues and apparatus therefore. US Patent 5,036,006 (1991).
- Hoekema, A., Hooykaas, P.J.J. & Schilperoort, R.A. Process for introducing foreign DNA into the genome of plants. US Patent 5,149,645 (1992).
- Hamilton, C.M. Binary BAC vector. US Patent 5,733,744 (1998).
- Yoder, J.I. & Lassner, M. Biologically safe plant trans- formation system. US Patent 5,792,924 (1998).
- Roa-Rodriguez, C. Nottenburg, C. Agrobacterium- mediated transformation (CAMBIA IP Resource, Canberra, Australia, 2001). http://www.cambiaip.org/
- Yoder, J.I. & Goldsborough, A.P. Transformation sys- tems for generating marker-free transgenic plants. Biotechnology 12, 263-267 (1994).
- Roa-Rodriguez, C & Nottenburg, C. Antibiotic resist- ance genes and their uses in genetic transformation (CAMBIA IP Resource, Canberra, Australia, 2003). http://www.cambiaip.org/
- Rogers, S.G. & Fraley, R.T. Chimeric genes suitable for expression in plant cells. US Patent 6,174,724 (2001).
- Santerre, R.F. & Rao, R.N. Recombinant DNA cloning vectors and the eukaryotic and prokaryotic transfor- mants thereof. US Patent 4,727,028 (1988).
- Bojsen, K. et al. Mannose or xylose based positive selection. US Patent 5,767,378 (1998).
- Odell, J.T., Nagy, F. & Chua, N.-H. Identification of DNA sequences required for activity of a plant pro- moter: the CaMV 35S promoter. Nature 313, 810-812 (1985)
- Sun, C.-W. & Callis, J. Independent modulation of Arabidopsis thaliana polyubiquitin mRNAs in differ- ent organs and in response to environmental changes. Plant J. 11, 1017-1027 (1997).
- Comai, L., Sanger, M.P. & Daubert, S.D. Figwort mosaic promoter and uses. US Patent 6,051,753 (2000).
- Gelvin, S.B., Hauptmann, R., Ni, M. & Cui, D. Chimeric regulatory regions and gene cassettes for expression of genes in plants. US Patent 5,955,646 (1999).
- Maiti, I. & Shephard, R.J. Full-length transcript (FLt) promoter from figwort mosaic caulimovirus (FMV) and use to express chimeric genes in plant cells. US Patent 5,994,521 (1999).
- Maiti, I. & Shephard, R.J. Promoter (FLt) for the full length transcript of peanut chlorotic streak caulimovirus (PCLSV) and expression of chimeric genes in plants. US Patent 5,850,019 (1998).
- van der Fits, L. & Memelink, J. Comparison of the activities of CaMV 35S and FMV 34S promoter deriv- atives in Catharanthus roseus cells transiently and stably transformed by particle bombardment. Plant Mol. Biol. 33, 943-946 (1997).
- Romano, C.P., Cooper, M.L. & Klee, H.J. Uncoupling auxin and ethylene effects in transgenic tobacco and Arabidopsis plants. Plant Cell 5, 181-189 (1993).
- Blechl, A., Anderson, O., Somers, D.A., Torbert, K.A. & Rines, H.W. Glutenin genes and their uses. US Patent 5,914,450 (1999).
- Harada, J.J., Lotan, T., Ohto, M.-A., Goldberg, R.B. & Fischer, R.L. Leafy cotyledon genes and their uses. US Patent 6,320,102 (2001).
- Benfy, P.N. & Chua, N.-H. Plant promoters. US Patent 5,110,732 (1992).
- Conkling, M.A., Mendu, N. & Song, W. Root cortex specific gene promoter. US Patent 5,837,876 (1998).
- Grundler, F., Nitz, I. & Puzio, P. Root-specific pro- moter. PCT Application WO 01/44454 (2001).
- Dobres, M.S. & Mandaci, S. Plant promoter useful for directing the expression of foreign proteins to the plant epidermis. US Patent 5,744,334 (1998).
- Beachy, R. & Bhattacharyya, M. Plant promoter. US Patent 5,824,857 (1998).
- Herrera-Estrella, L. et al. Chimaeric gene coding for a transit peptide and a heterologous peptide. US Patent 6,130,366 (2000).
- Dehesh, K. Plastid transit peptide sequences for effi- cient plastid targeting. US Patent Application 20020178467 (2002).
- Smeekens, S., Bauerle, C., Hageman, J., Keegstra, K. & Weisbeck, P. The role of the transit peptide in the routing of precursors toward different chloroplast compartments. Cell 46, 365-375 (1986)
- Komarnytsky, S. Borisjuk, N.V. Borisjuk, L.G. Alam, M. & Raskin, I. Production of recombinant proteins in tobacco guttation fluid. Plant Physiol. 124, 927-934 (2000).
- Bednarek, S.Y., Wilkins, T.A., Dombrowski, J.E. & Raikhel, N.V. A carboxyl-terminal propeptide is nec- essary for proper sorting of barley lectin to vacuoles of tobacco. Plant Cell 2, 1145-1155 (1990).
- Tague, B.W., Dickinson, C.D. & Chrispeels, M.J. A short domain of the plant vacuolar protein phyto- hemagglutin targets invertase to the yeast vacuole. Plant Cell 2,533-546 (1989).
- Kato, A., Hayashi, M., Kondo, M. & Nishimura, M. Targeting and processing of a chimeric protein with the N-terminal presequence of the precursor to the glyoxysomal citrate synthase. Plant Cell 8,1601-1611 (1996).
- Volokita, M. The carboxy-terminal end of glycolate oxidase directs a foreign protein into tobacco leaf peroxisomes. Plant J. 1, 361-366 (1991).
- Hayashi, M., Aoki, M., Kato, A., Kondo, M. & Nishimura, M. Transport of chimeric proteins that contain a carboxy-terminal targeting signal into plant microbodies. Plant J. 10, 225-234 (1996).
- DellaPenna, D. & Cunningham, F.X. Marigold DNA encoding beta-cyclase. US Patent 6,232,530 (2001).
- Hirschberg, J., Ronen, G. & Zamir, D. Tomato gene B polynucleotides coding for lycopene cyclase. US Patent 6,252,141 (2001).
- Cunningham, F.X. & Sun, Z., Genes of carotenoid biosynthesis and metabolism and a system for screening such genes. US Patent 5,744,341 (1998).
- Hirschberg, J., Cunningham, F.X. & Gant, E. Lycopene cyclase gene. US Patent 5,792,903 (1998).
- Graff, G., Zilberman, D., An intellectual property clearinghouse for agricultural biotechnology. Nature Biotechnology 19, 1179-1181 (2001).
- Atkinson, R.C. et al. Public sector collaboration for agricultural IP management. Science 301, 174-175 (2003).