Liposarcomas/atypical lipomatous tumors of the oral cavity: A clinicopathologic study of 23 cases (original) (raw)
Related papers
Head and Neck Pathology, 2012
Atypical Lipomatous Tumor/Well Differentiated Liposarcoma (ALT/WDLS) is a soft tissue sarcoma of intermediate malignant behavior, most frequently affecting the retroperitoneum and lower extremities. Oral liposarcomas are very rare neoplasms, the most common histological subtype being ALT/WDLS. In this study, three additional cases of ALT/WDLS located on the tongue (2 cases) and the lower lip (1 case), respectively, are described. Analysis of the salient clinicopathologic features of 63 oral ALT/WDLS cases previously reported in the English language literature, as well as of the 3 cases presented in this study, indicates that the indolent biologic behavior of this tumor justifies its designation as a locally spreading malignant neoplasm, affording a rather conservative surgical approach.
A B S T R A C T The benign soft tissue neoplasm of mature adipose tissue is known as lipoma. It is seen as a common entity in the head and neck region. Although lipomas are the most common tumors of mesenchymal origin in human body their occurrence in the oral cavity is rare. Intraoral lipomas may be noticed only during routine dental examination as most of them are asymptomatic and hence delay in seeking treatment. The etiology is still unclear. Various different theories explain the pathogenesis of this adipose tissue tumor. Based on histopathological findings, variants of oral lipoma have been identified. This article presents a comprehensive review of different types of lipomas of the oral cavity as it is important for an oral physician to diagnose intraoral lipomas and treat them conservatively.
Lipoma; a rarity in the oral cavity: a case report
Innovative Publication, 2016
Lipomas are rare, benign tumours of mesenchymal origin, representing 1 – 5% of all benign oral tumors. Clinically, intraoral lipomas present as slow growing, soft, asymptomatic mass. Histopathologically, they are composed predominantly of mature adipocytes admixed with collagenous tissue and may be surrounded by a thin fibrous capsule. Their diagnostic importance lies in the distinction from other benign connective tissue lesions, salivary gland neoplasms and liposarcomas. Complete surgical excision is the treatment of choice and recurrence is rare. Here we report a case of intraoral lipoma in the buccal mucosa. Key Messages: Lipomas are benign mesenchymal neoplasms composed of mature adipocytes. Only 2.2% of all lipomas occur in the oral cavity. Clinicians must be able to recognize these rare entities clinically and differentiate them from other connective tissue, salivary gland neoplasms and malignant adipocytic neoplasms so that adequate treatment can be done.
Lipoma is a common tumour to be found over a body but intraoral lipomas are a rare clinical entity and represent only about 0.1 to 5% of all neoplasms of the oral cavity. The buccal mucosa, tongue, and floor of the mouth are among the common locations. The clinical presentation is typically as an asymptomatic mass. The overlying epithelium is intact, and superficial blood vessels are usually evident over the tumour. Histopathologically, lipomas are benign soft tissue neoplasm of mature adipose tissue. Hereby, we report two cases of intraoral lipoma, one close to floor of mouth and other over buccal mucosa. Lesions were excised surgically and didn't show any recurrence.
Lipoma of Oral Cavity – A Case Report and Review of Literature
Journal of Evolution of Medical and Dental Sciences, 2021
Connective tissue neoplasms or soft tissue tumours as they are popularly called are mesenchymal neoplasms that affect any part of the body. They occur frequently in all organs including the head and neck region and the oral cavity is no exception. The frequency of their occurrence contributes to 15 - 20 % of all head and neck neoplasms and neoplasms of oral cavity form 1 - 4 % of the reported lesions,1,2 representing 2.2 % of all lipomas.3 In a study by Moreno SE et al. in 2016 the most frequently affected sites were the buccal mucosa followed by the lips, tongue, palate, and other areas of the oral cavity.4Here we are documenting a case occurring in the buccal mucosa.
International Journal of Oral and Maxillofacial Surgery, 2003
Lipomas represent about 1 to 5% of all neoplasms of the oral cavity. Although relatively common, few large series of intraoral lipomas and its variants are seen in the literature. Therefore, the authors present the clinical, histological and immunohistochemical features of 46 cases of intraoral lipomas reviewed from the files of the University of Campinas Dental School from 1970 to 2001. Most of the cases affected adults, without gender predilection, and the main involved sites were the buccal mucosa (21 cases), tongue (six cases), lips (six cases) and floor of mouth (five cases). The histological analysis revealed 21 cases of lipoma, 18 fibrolipomas, four intramuscular lipomas, two minor salivary gland lipomas and one spindle cell lipoma. PCNA and ki-67 expression indexes were higher in spindle cell lipoma, intramuscular lipomas and fibrolipomas compared to common lipomas, but the differences were not statistically significant. All lesions were removed surgically and none showed recurrence, regardless of the various proliferative activities.
Journal of Maxillofacial Surgery, 1976
The literature on Lipomata and intra-oral Lipomata is reviewed and a series of 24 cases presented. In this series the ntean age of presentation of the male patients was 53.8 years, whereas that of the females was 63.1 years. 33.30/0 of the tumours occurred on the inner aspect of the cheeks and of these 8 cases, six were males. Of the eight lesions occurring in the floor of the mouth and retromolar areas, all but one occurred in females. Evidence is presented to support the claim that intra-oral lipomata are indeed common benign neoplasms.
Lipomas of the oral cavity: clinical and histopathologic study of 41 cases in a Brazilian population
European Archives of Oto-Rhino-Laryngology, 2010
This study evaluated the clinical and histopathologic aspects of 41 cases of oral lipomas diagnosed in a Brazilian population. All records from patients diagnosed with oral lipoma between 1970 and 2008 were reviewed. Histological sections were evaluated by light microscopy. There was a predominance of females (2.4:1), with a peak incidence between the sixth and seventh decade. The buccal mucosa was the most aVected site (53.7%), followed by the buccal sulcus (14.6%) and tongue (9.8%). Tumor size ranged from 0.5 to 10 cm and the mean reported duration was 48 months. Histologically, the following variants were identiWed: lipoma (41.5%), Wbrolipoma (34.1%), spindle cell lipoma (9.8%), sialolipoma (9.8%), osteolipoma (2.4%), and chondrolipoma (2.4%). Most tumors were well delimited, irrespective of the variant. Lipomas are rare tumors of the oral cavity. The characterization of new variants, such as sialolipomas, and the identiWcation of histological subtypes in already known variants, such as low-fat and fat-free spindle cell lipomas, highlight the importance for careful microscopic evaluation of these tumors, which might be combined with immunohistochemistry in some cases.
Atypical lipomatous tumor of the oropharynx: A case report
Clinical Case Reports
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Atypical lipomatous tumors of the tongue: report of six cases
Virchows Archiv, 2009
The occurrence of liposarcoma in the tongue is rare with only 34 cases published so far. We report six new cases of atypical lipomatous tumor (ALT) of the tongue, and detection of mdm-2 and CDK4 expression by immunohistochemistry and fluorescence in situ hybridization (FISH), respectively, was performed. The series comprised three males and three females, aged 11-78 years. The tumors arose at the lateral side of the tongue, and in one case, multiple tumor nodules were noted. Follow-up information in five cases (range from 4 to 159 months) revealed one local recurrence at 6 months. Microscopically, four cases had features of lipoma-like ALT, whereas two cases displayed patterns of sclerosing ALT. Immunohistochemically, tumor cells revealed expression of vimentin (five of five), S100 (five of five), mdm-2 (three of five), and CDK4 (four of five). Two cases were also examined by FISH; amplification of mdm-2 gene was found in both cases, whereas amplification of CDK4 gene was present in one case only. To the best of our knowledge, this is the third largest series reporting occurrence of ALT in the tongue and the first one where analysis of mdm-2 and CDK4 proteins/ genes expression/amplification was performed. Both these markers may be of help in the differential diagnosis of ALT versus lipoma. Although most ALTs of the tongue behave in the nonaggressive fashion, they may recur locally. Based on current data, the term ALT is strongly recommended for tumors occurring in the tongue to prevent inadequate treatment.