Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate (original) (raw)

Molecular hydrogen (H2) exhibits antioxidative effects, and its role in alleviating inflammation beyond ischemia reperfusion is still being explored. This study utilizes dextran sodium sulfate (DSS)-induced colitis in mice as a model for human inflammatory bowel disease to investigate H2's effects on colon inflammation. The findings reveal that H2 administration significantly mitigates the clinical and histological consequences of DSS-induced colitis, reduces cytokine production, and enhances gut health, suggesting its potential as a therapeutic agent for inflammatory bowel diseases.