Assessment of Kidney Function Tests in Diabetes Mellitus Patients under Insulin Doses in Arar Region, Kingdom of Saudi Arabia (original) (raw)
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Evaluation of diabetes mellitus type 2 effects on kidney function
Mediterranean Journal of Pharmacy & Pharmaceutical Sciences, 2023
Type 2 Diabetes mellitus contributes to the development or progression of many chronic and agerelated pathological processes. One of the major risk factors for morbidity and mortality among patients with diabetes is renal and vascular disease as well as heart disease. Type 2 diabetes mellitus was associated with a significantly increased age of kidney disease with higher urea and creatinine levels. 76 Libyan subjects participated in the study. The subjects were divided into three categories. One group hosts diabetes case (n=40) while the other group serves as a control (n=12) and the other group has no type 2 diabetes mellitus but urea and creatinine levels are elevated (n=36). After oral informed consent of the study participants, 5 ml of venous blood was drawn under sterile conditions for whole blood analysis. Fasting blood sugar was analyzed. Urea and creatinine levels were compared between diabetic and non-diabetic patients. However, a statistical analysis was performed using IBM SPSS version 26 where the correlation between parameters was analyzed by an independent samples t-test. In this study, patients with type 2 diabetes mellitus caused a significant increase in urea and creatinine compared to the control group. The study indicated that type 2 diabetes mellitus increases the damage to the kidney function.
Diabetes mellitus is one of the chronic metabolic disorder that cause serious renal problems. The present study was undertaken to investigate the effect of renal dysfunction in insulin dependent and non-insulin dependent diabetic patients. Samples of 100 individuals were collected i.e. 33 individuals from each insulin dependent and non -insulin dependent diabetic patients and 34 were control group. Blood samples from the individuals were collected for glucose estimation in sodium flurried tube while urine, creatinine and uric acid values were determined through lithium heparin coated tube. The weight was found significant in both groups as compared to control, while other parameters such as population, habits, nutrition and body mass index (gender, age, ethnic groups, location, marital status, occupation income/month, smoking, alcohol, drugs, dietary habits, dietary assessment, obesity, height) were nonsignificant (P>0.05). In case of disease effects, body effects, serum, urinary profile the parameters (duration, family history of disease, treatment, blood sugar, blood urea, blood creatinine, urinary protein, urinary sugar) were found highly significant (P<0.05) in both groups of diabetic patients, while the other parameters (diabetes, diabetes types, allergy, blood pressure (upper) blood pressure (lower), radial pulse, hypertension, heart disease, doctor visit, and uric acid) were non-significant between different groups. It is concluded that renal function was affected in both groups of diabetic patients based on data received from the above different parameters.
Study Effect of Blood Glucose Level on Renal Failure in Peoples Suffering from Diabetes
International Journal of Science and Research (IJSR), 2016
This study was accompanied in AL-Emam AL-Sajjsd hospital in al najaf al ashraf city through the period from May 2015 to September 2015. To evaluate serum lipid profile, albumin and Hb in patients, it involved 77 patients, 53 male and 24 females' patients, and their range of age from 21 to 65 years. The patient was identified as suffering (renal failure caused by diabetic) for both gender based on the history, clinical analysis test for renal function and DM. The control groups were 50; they were collected from medical staff and relatives who were free of kidney disease, diabetes and hypertension. Number of men is thirty and twenty women; the ages range btween twenty-two and sixty-six years. The samples of blood were take from the case (8-12) hours after night fasting, One of the most important causes that cause renal failure is diabetes by causing hurt to blood vessels in the organ (kidney) the units of filtering in the kidney are filled with small blood vessels. For along time, high glucose levels in the blood can cause narrow and clogged. The changes in parameters btween the levels in both male and female patients and their control, a positive significant change in (Uric acid, Blood glucose{Sugar}, Urea, Creatinine, K, PO4, GOT, GPT, Iron, Ferretin, TIBC, UIBC, TS%, ETIBS) levels of male patients as compared with the control group, the same table states to negatively significant changing in levels of (Ca, Alb, Hb, PCV) in the tow gender patients with renal failure as paralleled with group of control. Just one item shows on significant change the item is Na when we compared with their control group. The effect of high blood sugar levels leads to many complications in vital human. There are no direct relationship between high blood sugar and diabetes on the hand versus the low level of hemoglobin or high level iron status on the other hand
Renal Function Test on the Basis of Serum Creatinine and Urea in TYPE-2 Diabetics and Nondiabetics
Bali Medical Journal, 2014
Background: Type-2 diabetes mellitus has quickly become a global health problem due to rapidly increasing population growth, aging, urbanization and increasing prevalence of obesity and physical inactivity. Diabetic nephropathy is one of the major causes of chronic renal failure. Both serum urea and creatinine are widely used to assess the function of kidney. This study was conducted to observe the impaired renal function in type 2 diabetics and compare with non-diabetics controls. Method: To determine the incidence of renal dysfunction in diabetics in Nepalgunj medical college and Hospital , Nepalgunj , Banke, Nepal , blood samples from 100 diabetic subjects and 100 non-diabetic controls were taken between the period 1 st February , 2012 to 31 st January , 2013 for investigation of plasma glucose fasting(FPG), blood urea and serum creatinine. These biochemical parameters were determined by using a fully automated clinical chemistry analyzer. Results: Our findings showed that the level of blood urea (P<0.0001, 95%Cl) and serum creatinine (P≈0.0004,95%Cl) were significantly higher in type 2 diabetics as compared to non-diabetics in both male and female. There was no significant difference between diabetic male and female. 15 out of 100 diabetes samples have high urea level whereas 7 out of 100 had increased creatinine level. In control only 3 samples had high urea value and 1 had high creatinine level. There was statistical significant increased in urea level with increased in blood sugar level. Conclusion: Blood urea and creatinine is widely accepted to assess the renal functions. Good control of blood glucose level is absolute requirement to prevent progressive renal impairment.
Correlative Study in Diabetic Patients for Blood Glucose Level and their Kidney Functions
International Journal of Scientific Research in Science and Technology, 2022
Diabetes mellitus (DM) and hypertension are now widely recognized as the leading causes of end-stage renal disease. Because DM is so common among ESRD patients, there is a great need to understand more about how to avoid and manage it. This paper attempt to make a Correlative Study in Diabetic Patients for Blood Glucose Level and their Kidney Functions conducted at Jaypee Multi-Specialist Hospital Noida laboratory medicine. Correlation between high glucose and high creatinine levels were made in the study and it was indicated that the level of glucose from the samples is higher than that of creatinine levels. The lower, higher and normal creatinine level were duly examined in the study. The samples for the study were selected from the general patient enrolment list obtained from the Jaypee Multi Specialist Hospital Noida Laboratory Medicine. However, the test was conducted during the six months’ project work and random sampling procedure was used in selecting the samples. The results indicate that based on age distribution, the percentage of patients with higher glucose is higher than the percentage of normal creatinine level, likewise the percentage of patients with high creatinine level is more than that of normal levels respectively. Hence it was concluded that based on the correlation made the percentages of patients with high level of glucose is higher than that of patients with high creatinine levels.
The Professional Medical Journal, 2016
Objectives: To determine diagnostic accuracy of spot urine Protein to creatinineratio for detection of diabetic nephropathy taking 24-hour urinary protein as gold standard.Study Design: cross sectional. Settings: Medical and Radiology department of Allied hospitalFaisalabad. Duration: 12-12-2013 to 12-06-2014. Sample size: 134. Material & Methods: Itwas a cross-sectional study done in Medical Unit I, Allied Hospital Faisalabad. 134 patients withsuspicion of diabetic nephropathy were included. 24-hour urine sample collected by instructingpatients to begin collection immediately after completion of first voiding in morning and tocollect all urine into same container having 5mL of 10% thymol in iso-propanol as a preservativefor 24-hours. This was thoroughly mixed, 2mL was taken for evaluation of proteins. P.C ratiowas calculated by dividing Urinary Protein concentration by Urinary Creatinine concentration.Results: The mean age of patients was noted as 55.11±6.79 years. There were 62.7%...
Effect of Hemodialysis on Some Biochemical Parameters in Diabetic Nephropathy Patients
Indian Journal of Forensic Medicine & Toxicology
Diabetes mellitus is a worldwide epidemic and is associated with long-term damage and causes dysfunction of several organs like kidney leading to diabetic nephropathy. This study was designed to evaluate some biochemical aspects. This study was conducted on 95 patients which included (35) HD patients with diabetes and (35) HD patients without diabetes and (25) Type 2 diabetes mellitus patients, who attended at Ramadi General Hospital. For the purpose of comparison, (25) samples as control. Several tests were performed such as FSB, urea, creatinine, glomerular filtration rate (GFR), albumin, sodium ion, calcium ion, Phosphorus ion, potassium ion and magnesium ion were calculated. This study showed the level of urea and creatinine were a significant increase in HD patients with diabetes(128.29±22.59 and 7.1±1.76) mg/dl respectively, and HD patients without diabetes were (125.74±23.28 and 6.80±2.71) mg/dl respectively. The levels of Na + and Ca ++ were decrease in HD patients with diabetes (137.6±4.8 mmol/L and 6.72±1.76mg/dl) respectively. The levels of P, K + and Mg ++ were a significant increase in HD patients without diabetes(6.26±0.84 mg/dl, 5.52±0.61 mmol/L and 2.2±0.13mg/dl) respectively. The urea, creatinine and GFR are simple and useful biomarkers which can serve as predictor tests for assessing kidney functions in diabetic patients.
Correlation of Serum Urea and Serum Creatinine in Diabetics patients and normal individuals
IP innovative publication pvt. ltd, 2020
Diabetic Nephropathy in the long run leads to end Stage Renal Disease (ESRD). Serum Creatinine and Serum Urea are recognised as ideal markers to co-relate the progression of diabetic nephropathy. Diabetic Nephropathy is clinically diagnosed with decrease in Glomerular function rate (GFR), probability of hypertension, cardiovascular diseases and morbidity or mortality caused due to it. The early detection of an imbalance in the level of Urea and Creatinine levels can assist in the diagnosis and prevention of Diabetic Renal diseases and its progression. In this study, the period of the commencement of Diabetes and its severity is intensely correlated with an abnormal level of Urea but not so with that of Creatinine. While Creatinine is regarded as greater sensitive index of kidney function than Urea and hence this justifies as the requirement for a perfect filtration marker.
Frequency of Renal Diseases in Diabetic Patients
Pakistan biomedical journal, 2019
Diabetic nephropathy, also known as diabetic kidney disease is the chronic loss of kidney function occurring in those with diabetes mellitus. Diabetic nephropathy is one of the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally. Protein loss in the urine due to damage to the glomeruli may become massive, and cause a low serum albumin with resulting generalized body swelling (edema) and result in the nephrotic syndrome. Objective: The aim of this study was to determine the frequency of renal disease in diabetic patients and its complications in Pakistan. Methods: A cross sectional study was conducted at Renal and Diabetic Departments of the Sir Ganga Ram Hospital, Lahore, over a period of 3 months, after obtaining the ethical approval from The University of Lahore. A total number of 100 Diabetic patients were selected through non probability convenient sampling technique. Patients of both sexes and all age groups were included. Results: In this study 60% were male and 40% were female. About 41% diabetic patients were 1-6 month of age, 42% were 1-5 years old and 1% of 18-23 years old who had renal diseases while 9% patients were without any renal disease. whereas the prevalence of diabetes is more in infants than others which is 35%. But there was not significant association between onset of renal diseases with the onset of diabetes mellitus with p-value 0.24. Conclusions: Results of current study showed that diabetes mellitus effecting individuals of all ages equally but there was not significant association between diabetes and renal diseases.
Farkhanda Naseem et al, Diabetic Nephropathy: Principles Of Diagnosis And Treatment., Indo Am
Diabetes mellitus is one of those diseases whose ratio is increasing at a very rapid rate worldwide. It is one of the leading causes of death in patients having end stage renal diseases. Diabetes mellitus comes up with various complications which are difficult to handle. These complications are associated with effects of Diabetes on the glomerular microvasculature of the kidneys. Patients who have a history of several years of renal disease and diabetes, they are more likely to develop Diabetic Nephropathy. Since medical science has progressed, many new diagnosis and treatment options are available, but unfortunately there isn't any permanent cure. The purpose of this paper is to throw light on various therapeutic strategies that are currently used by doctors to increase the understanding of DN and to help patients fight against it. The study was carried out randomly in different hospitals of Lahore and general data was collected to study in detail the occurrence, diagnosis and treatment which is carried out for diabetic nephropathy.