A Prospective Study on The Pattern of Hepatic Enzymes After Abstinence In Alcohol Dependence Patients (original) (raw)
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Biochemical Effects on the Liver of 1 Month of Alcohol Abstinence in Moderate Alcohol Consumers
Alcohol and Alcoholism, 2018
In this study, 16 moderate alcohol consumers without structural liver disease ceased alcohol intake for 1 month and underwent liver measurements at three time points. Gamma-glutamyl transferase, although within the normal range, decreased significantly after abstinence and increased after the resumption of alcohol consumption. Short summary: In this study in healthy moderate alcohol consumers, we observe that one month of alcohol abstinence results in decreased gamma-glutamyl transferase levels, which return to baseline levels after resumption of alcohol consumption.
Indian Journal of Mental Health, 2020
Background: The aim of the research was to study the biochemical profile of the male patients diagnosed with alcohol dependence syndrome and its correlation with the severity of dependence. Methodology: A descriptive study comprising of 60 patients admitted in the psychiatry de-addiction clinic at HSK hospital from 1st July 2017 to 31st December 2017 was done after taking institutional ethical committee clearance. A semi-structured proforma was used to determine the socio-demographic details like education, occupation, socioeconomic status etc. the severity of dependence was determined using Severity of Alcohol Dependence Questionnaire (SADQ) scale and basic biochemical tests were performed. Descriptive analysis using an appropriate statistical test was done. Results: The mean age at presentation was 37.9 years. Out of 60 patients, 21 (35%) had mild dependence, 24 (40%) had moderate dependence and 15 (25%) had severe dependence. Hepatic enzymes AST and ALT were raised in 76.67% and 66.67% patients respectively. AST to ALT ratio was above 2 in 11.67% patients. There was a significant correlation between total SADQ scores and Alanine Transaminase (ρ = 0.281, P = 0.03, n = 60). Conclusion: The biochemical tests were deranged in most of the patients with alcohol dependence. Certain markers can be developed based on their significant association with the dependence levels, thus, helping in early diagnosis and prevention of alcohol dependence syndrome.
Biochemical Evaluation of Patients of Alcoholic Liver Disease and Non-alcoholic Liver Disease
Indian Journal of Clinical Biochemistry, 2013
Alcoholic liver disease (ALD) is due to excessive alcohol intake for long duration. Distinguishing ALD from non-ALD (non-alcoholic steatohepatitis, hepatitis of viral origin) is difficult as patient may deny alcohol abuse. Clinical examination, histology and serology may not differentiate these conditions. Accurate diagnosis is important as management of ALD differs from non-ALD patients. The aim of our study was (1) To evaluate the patients of ALD and non-ALD by biochemical parameters compared to controls, (2) To assess whether these parameters can differentiate ALD from non-ALD. Study was carried out on 50 patients of ALD in group I and 35 patients of NASH (non-alcoholic steatohepatitis) and acute viral hepatitis each in group II. Age matched healthy controls n = 50. Selection criteria-history of alcohol intake (amount and duration), clinical examination, sonography of abdomen, serum alanine transaminase (ALT) and bilirubin levels. Blood samples were analyzed for bilirubin, aspartate transaminase (AST), ALT, alkaline phosphatase (ALP), gamma glutamyl transferase (GGT) by kinetic method. Statistical analysis was done by Student unpaired 't' test. Patients of ALD have raised AST/ALT ratio (De Ritis ratio) ([2), ALP and GGT compared to controls (P \ 0.01).There is significant difference in AST/ALT ratio, serum GGT and ALP in ALD group compared to that in NASH and acute viral hepatitis (P \ 0.05). This study suggests that De Ritis ratio [2 in ALD patients may be due to alcohol induced hepatic mitochondrial injury and pyridoxine deficiency. High GGT and ALP values may indicate enzyme induction by alcohol and mild cholestasis. Thus ALD patients have severe hepatic damage. De Ritis ratio \1 and normal to mild elevation in GGT level in NASH and acute viral hepatitis suggest mild hepatic injury of non-alcoholic origin. Our study concludes that ALD patients can be differentiated from NASH and acute viral hepatitis with certainty by measuring serum AST/ALT ratio, GGT and ALP. These biochemical parameters may help clinicians to support the diagnosis of ALD and non-ALD.
Introduction: Chronic alcohol intake can lead to functional disturbances and irreversible lesions in organs such as the liver, brain, pancreas, gastrointestinal tract, heart, and endocrine gland. Determining the serum activities of various enzymes such as aminotransferases, glutamate dehydrogenase (GDH), and gammaglutamyltransferase (GGT) has widely been used as a method of screening for hepatic involvement in chronic alcoholism. Aim: This study was conducted to analyze multiple serum enzyme level changes in a chronic alcoholic with special reference to GGT and lipid peroxidase Materials and Methods: 34 subjects were selected for the study. They are all male individuals with a positive history of chronic alcohol abuse. 10 healthy male volunteers who matched in age and socioeconomic status served as the controls. Result: The activity of serum enzyme levels in test and control groups has been statistically analyzed. There was a highly significant difference (p<0.001) in the mean values of the Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), GGT of these two groups, whereas Serum lipid peroxidase (SLP) was less significant (p<0.01). The concentration of GGT was significantly low (p<0.001) in controls compared to that in the alcoholics. Conclusion: GGT can be taken as a marker of chronic alcoholism, provided serum bilirubin, SAP is within the reasonably average level This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
Journal of Pharmaceutical Research International, 2022
Background: Alcoholic liver disease is one of the primary medical complication of chronic ethanol abuse. It encloses a wide spectrum of diseases comprising of fatty liver, alcoholic hepatitis, alcoholic cirrhosis and hepatocellular carcinoma. Methodology: A prospective, observational study was done at AIG hospitals in the department of hepatology for a period of 6 months. A total of 200 patient’s diagnosed clinically and biochemically with various spectrum of ALD were recruited for the study.Non-invasive prognostic scores were calculated at the time of admission and correlated with severity of disease. Results: Among 200 study participants, 34.8% belongs to age group of 36-45 years. All were male patients with age group ranged from 25 to 73 years. We observed the high levels of alkaline phosphatese, aspartate aminotransferase/alanine aminotransferase ratio, mean corpuscular volume, total bilirubin and international normalized ratio in Severe Alcoholic hepatitis patients. Non-invasiv...
Differential Effects of Alcohol Drinking Pattern on Liver Enzymes in Men and Women
Alcoholism: Clinical and Experimental Research, 2004
Background: Increasing evidence suggests that drinking pattern may have powerful implications for health; however, very few studies have focused on the association between drinking pattern and risk of alcoholic liver damage. This study was aimed at examining the association of ␥-glutamyltransferase (GGT), aspartate aminotransferase, and alanine aminotransferase with current alcohol consumption and with some aspects of drinking pattern (e.g., drinking frequency during the week and in relation to food consumption).
European Journal of Clinical Investigation, 1981
Serum activity of gamma-glutamyltransferase, aspartate aminotransferase and alkaline phosphatase were determined in 316 patients attending an out-patients clinic for treatment of alcoholism. The activity of gamma-glutamyltransferase was raised in 34% and that of aspartate aminotransferase and alkaline phosphatase in 18% and 7%. Neither the activity of gamma-glutamyltransferase, aspartate aminotransferase nor alkaline phosphatase showed any significant ( P > 0.05) correlation with the history of alcohol consumption. The activities of gamma-glutamyltransferase and aspartate aminotransferase were raised significantly more often in patients with recent alcohol consumption than in patients who had abstained for more than 9 days. The concentration of alkaline phosphatase was not significantly ( P > 0.05) different in these groups. The predictive value of raised and normal activities of gamma-glutamyltransferase, in deciding whether a patient had had recent alcohol consumption or not, was not superior to the predictive value of raised and normal activities of aspartate aminotransferase.
Risk assessment of alcohol and obesity on liver enzymes (transaminases, cholestatic)
Health, 2012
Background: This study was designed to investigate the BMI and alcohol consumption effects on hepatic enzymes. The degree of alteration among moderate drinkers is still unclear. Objective: To determine causes of liver failure due to alcohol and obesity. We observed the association between moderate alcohol consumption, body mass index (BMI; in kg/m 2) and transaminase, cholestatic enzymes. Design: Serum alanine aminotransferase (ALT), alkaline phosphate (ALP), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were examined in 995 healthy persons. In this study 400 persons were reported as abstainers and 595 participants involved as a moderate drinkers. The study population was further split into according to BMI as follows: <19 (underweight), ≥19 and <25 (normal weight), ≥25 and <30 (overweight), and ≥30 (obese). Results: Serum ALT (P < 0.002), GGT (P < 0.001) and ALP (P < 0.001) but not AST (P < 0.883) activities in moderate drinkers were higher than those in abstainers. Mean ALT activity is higher in obese and over weight in alcohol consumers and abstainers as compared to mean AST activity in the same groups. ALP activity was increased with BMI in moderate drinkers. In abstainers activity of ALP shows weak relation in order to BMI. Conclusion: The result of moderate alcohol use raises activity of hepatic enzymes with increasing BMI. Most participants with alcohol consumption have an AST/ALT ratio above 1.
Study of Biochemical Markers in Alcoholic Liver Disease: Hospital-Based Case Control Study
Alcoholism is a chronic, progressive and potential cause of liver disease in the western world and it is most common in Nepal. Numerous data are available regarding alcoholic liver disease (ALD) with biochemical and hematologic indicators but very few works have been made in the Nepalese context. Hence, an effort has been made to evaluate the status of biochemical markers in ALD among the Nepalese subjects.166 ALD cases were enrolled in our OPD. Out of total ALD patients, 110 (66.27 %) patients were male and 56 (33.73%) patients were female. ALD patients had significantly low body weight (p<0.05) and low BMI (p<0.05) compared to control. Hyperbilirubinemia and hypoalbuminemia correlate with alcohol intake. Albumin / globulin ratio significantly decreased in ALD. The elevated levels of AST (p<0.001), ALT (p<0.01), ALP (p<0.001), GGT (p<0.001) and AST/ALT ratio > 1 were found with ALD patients respectively. The percentage of hemoglobin and total number of RBC were found to be significantly decreased, whereas mean corpuscular volume (MCV) significantly increased in ALD. The findings of the present study are consistent with previous studies, suggesting that hepatocytes damage causes leak of these enzymes into the circulation. This study concludes that biochemical and hematological parameters is dependable marker of ALD.