Clinical features and the prognostic significance of ocular sarcoidosis (original) (raw)
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Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG / World Association of Sarcoidosis and Other Granulomatous Disorders, 2015
To describe the ocular and systemic features in biopsy proven (definite) and non-biopsy proven (clinical) ocular sarcoidosis and to compare the ocular features with those proposed by the International Workshop for Ocular Sarcoidosis (IWOS). Retrospective chart review of 83 patients who attended a tertiary referral uveitis clinic and were diagnosed with sarcoidosis. Patients were divided into two groups based on the type of diagnosis: those who had tissue biopsy confirmed diagnosis 'definite sarcoidosis' (n= 42; 50.60 %) and those who had 'clinical sarcoidosis' (n= 41; 49.40%). Ocular and systemic manifestations, including lung function tests and bronchoalveolar lavage findings were compared in the two groups. The ocular features were also compared with the categories laid down by the International Workshop on Ocular Sarcoidosis (IWOS). The mean age at presentation was 38.75 years (SD=12.33), 55.42% patients were female and mean follow-up was 24.35 months (SD=18.35)...
Ocular sarcoidosis: clinical experience and recent pathogenetic and therapeutic advancements
International Ophthalmology, 2020
Purpose To describe the ocular manifestations in a cohort of patients with systemic sarcoidosis (SS). Recent advances in the pathophysiology, diagnosis, and therapy of SS are also discussed. Methods Data from 115 Italian patients diagnosed between 2005 and 2016 were retrospectively reviewed. All but the first 17 patients underwent a comprehensive ophthalmologic examination. The diagnosis was based on clinical features, the demonstration of non-caseating granulomas in biopsies from involved organs, and multiple imaging techniques. Data on broncho-alveolar lavage fluid analysis, calcemia, calciuria, serum angiotensin-converting enzyme levels and soluble interleukin-2 receptor levels were retrieved when available. Results Ocular involvement, detected in 33 patients (28.7%), was bilateral in 29 (87.9%) and the presenting feature in 13 (39.4%). Anterior uveitis was diagnosed in 12 patients (36.4%), Löfgren syndrome and uveoparotid fever in one patient each (3%), intermediate uveitis in 3...
Asploro Journal of Biomedical and Clinical Case Reports, 2019
Sarcoidosis, or Besnier-Boeck-Schaumann disease, is systemic granulomatosis of an unknown etiology characterized by the formation of immune granulomas in the affected organs. The clinical presentation can be very variable [1]. The diagnosis is made on a bundle of clinical, paraclinical and anatomopathological arguments when a biopsy is performed. The most commonly affected organs are the mediastinal lymphatic system, lungs, skin, and eyes. Ocular manifestations of sarcoidosis could take very different forms. We could find it in one in four patients and it may be revealing of sarcoidosis in 19% of cases [1]. All the tunics of the eyeball and the ocular adnexa can be involved.
Pattern of ocular manifestations in patients with sarcoidosis in developing countries
Acta Ophthalmologica Scandinavica, 2007
Purpose: Sarcoidosis is increasingly diagnosed in developing countries, although it was earlier thought to be uncommon. We describe the pattern of ocular manifestations in sarcoidosis in India.Methods: A total of 48 consecutive patients with histologically confirmed sarcoidosis, referred to a teaching university hospital, underwent a detailed ophthalmological examination, irrespective of whether they had eye symptoms or not.Results: Ocular involvement was seen in 14 (29%) patients. The mean age at presentation was 50 years, and neither two peaks of incidence nor a female preponderance could be demonstrated. The majority of patients had chronic disease. Posterior uveitis was distinctly more common (12/14) than anterior (5/14) uveitis. Conjunctival involvement was uncommon. These findings differ from those reported in the Western literature.Conclusions: Eye involvement is common in sarcoidosis in India and may occur without ocular symptoms. Posterior segment involvement is more common than has been reported. Ophthalmologists need to be aware of ocular involvement in this disease as untreated disease can have significant visual consequences.
IP Innovative Publication Pvt. Ltd., 2018
Purpose: To study the clinical profile of patients with ocular sarcoidosis using the new International Workshop for Ocular Sarcoidosis (IWOS) guidelines, in a tertiary care hospital in South India. Materials and Methods: A retrospective observational study where the records of patients diagnosed to have sarcoidosis were analyzed and regraded according to the new guidelines by the International Workshop for Ocular Sarcoidosis. Results: Among the 36 sarcoidosis patient records evaluated in the study period, respiratory involvement was found in 80.6% whereas ocular involvement in 38.9% cases. Uveitis was the most common ocular manifestation seen in 59.1% of those who underwent ocular evaluation. Applying the IWOS guidelines in our patients with uveitis, we found, two had definite ocular sarcoidosis; seven had presumed ocular sarcoidosis; four had probable ocular sarcoidosis and none with possible ocular sarcoidosis. Conclusion: Sarcoidosis is not uncommon in India. Ocular features are common and need to be screened in all patients diagnosed with systemic sarcoidosis. An ophthalmologist can use IWOS criteria in cases of uveitis to clinically diagnose and refer cases for systemic evaluation of sarcoidosis. Keywords: Angiotensin converting enzyme, Sarcoidosis, Uveitis.