Poster A4 (original) (raw)

The mobilization of heavy metals by man through extraction from ores and processing for different applications has led to the release of these elements into the environment. Since heavy metals are non

Heavy metal exposure can lead to death and disability. A variety of sources including soil, wastewater, mining activities, industrial waste, sewage wastes, pesticides used in agriculture and automobile exhaust gas contribute to the overall metal burden. The adverse health effects of heavy metals such as lead, arsenic, mercury, and cadmium have become more complicated and challenging for the world owing to the highly complex nature of heavy metal-biological interactions. Although the mechanism of action of metals varies, the only way to help the body struggle with the heavy metal burden is to remove heavy metals from the body and eliminate, or reduce, the possibility of re-exposure. It is thought that the use of biomarkers to detect early damage to the cardiovascular system by exposure to low amounts of heavy metals may be beneficial. Furthermore, the clinical status for the patient can be questioned by determining long-term low levels of exposure to humans for doses empirically used to induce cardiotoxicity.

Context For decades, there has been epidemiologic evidence linking chronic toxic metal exposure with cardiovascular disease, suggesting a therapeutic role for metal chelation. Given the lack of compelling scientific evidence, however, the indications for metal chelation were never clearly defined. To determine the safety and efficacy of chelation therapy, the National Institutes of Health funded the Trial to Assess Chelation Therapy (TACT). TACT was the first double-blind, randomized, controlled trial to demonstrate an improvement in cardiovascular outcomes with edetate disodium therapy in patients with prior myocardial infarction. The therapeutic benefit was striking among the prespecified subgroup of patients with diabetes. Design We review the published literature focusing on the atherogenic nature of diabetes, as well as available evidence from clinical trials, complete and in progress, of metal chelation with edetate disodium therapy in patients with diabetes. Results The TACT ...

Summary Heavy metals represent both essential components for the maintenance of normal biological functions, and toxic agents with damaging consequences when present in inappropriate amounts. In this review, we will consider the factors affecting metal toxicity and the principal chelating agents used for the treatment of metal intoxications.

Heavy metals are toxic to both human and plant, cause water and soil pollution. It is necessary to eliminate the toxic heavy metal ions from the body system before it is released into the environment. Chelating agents are able of binding to toxic heavy metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. There are several methods are applied for removal of heavy metal ions but Chelation therapy is the most advanced one. In this review, we present a revise of the existing chelating agents for the treatment of heavy metals and metalloid intoxications. Introduction Heavy metals are the class of metallic/metalloids elements that have a comparatively high density compared to water [1]. In recent years, there has been a most crucial issue for our biological and worldwide public health concern associated with environmental contamination by heavy metals. The reuse, separation, and purification of industrial w...

Cardiovascular diseases (CVDs) constitute the first cause of death among the population of developing and developed countries. Atherosclerosis, which is a disorder with multifactorial etiopathogenesis, underlies most CVDs. The available literature includes ample research studies on the influence of classic cardiovascular (CV) risk factors. However, environmental exposure to heavy metals, among other substances, is still an unappreciated risk factor of CVDs. This study aimed to assess the concentration of some heavy metals (copper (Cu), zinc (Zn), manganese (Mn), cobalt (Co), and iron (Fe)) in the blood serum of postmyocardial infarction (post-MI) patients and patients free from myocardial infarction (MI) as well as estimate the relationship between the occurrence of MI and increased concentration of heavy metals. The concentration of heavy metals (Cu, Zn, Mn, Co, and Fe) was assessed using the inductively coupled plasma mass spectrometry technique in a group of 146 respondents divid...