Combinatorial chemistry in higher school: Ten-year experience of research, educational, and managerial projects (original) (raw)
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Combinatorial chemistry revolutionized discovery by enabling the rapid synthesis and screening of vast libraries containing millions of unique compounds. This review explores the core principles of library creation, including combinatorial explosion and parallel synthesis techniques like solid-phase and parallel synthesis. We discuss the advantages and limitations of this approach, highlighting its impact on accelerating discovery timelines in drug discovery, materials science, and beyond. Future advancements in automation, high-throughput screening, and computational modeling are poised to further enhance the power of combinatorial chemistry, driving innovation across diverse scientific fields.
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The paper describes and compares the utility of the three chemical methods used for the synthesis of combinatorial libraries: (1) the mixed reactant method, (2) the portioningmixing method, and (3) light-directed synthesis. It also deals with historical aspects of these methods and with the most important screening methods ascociated with them. Q 1995 WII~Y-IIS, inc