1994 JAAD _ Leukemia cutis in acute lymphoblastic leukemia-.pdf (original) (raw)

Leukemia Cutis (Answer to the Clinical Quiz of the Previous Issue)

Shiraz E Medical Journal

Skin infiltration in leukemia occurs rarely. Leukemia cutis has a wide range of cutaneous manifestations from maculopapular to tumorous stage. Patients with Leukemia cutis usually have concomitant systemic leukemia, but occasionally skin involvement precedes the in-volvement of the bone marrow or peripheral blood. Complete remission could be achieved with chemotherapy, however, the long term prognosis is poor.

Recurrent Aleukemic Leukemia Cutis in a Patient With Pre-B-Cell Acute Lymphoblastic Leukemia

Journal of Clinical Oncology, 2013

A 27-year-old man with thrombocytopenia (31 ϫ 10 9 /L) was admitted to the hospital for a scheduled platelet transfusion. On admission, he was noted to have an asymptomatic skin lesion on his left cheek that had been present for 3 weeks. The patient had a medical history significant for pre-B-cell acute lymphoblastic leukemia (pre-B-ALL), diagnosed 2 years prior. He experienced complete remission for 1 year after induction chemotherapy with daunorubicin, vincristine, and intrathecal methotrexate, but subsequently developed disease relapse of the bone marrow, was treated with high-dose cytarabine, but still had residual disease after repeat bone marrow biopsy. He underwent conditioning with 120 Gy total-body irradiation and 60 mg/kg of etoposide followed by 10/10 HLA-matched unrelated donor allogeneic hematopoietic stem-cell transplant 7 months before his admission. Surveillance bone marrow biopsy, peripheral-blood smear, and lumbar puncture done 2 months before admission were negative for leukemia.

Leukemia Cutis in a 32-Year-Old Male with Acute Myeloid Leukemia

Journal of Enam Medical College, 2019

Leukemia cutis (LC) is a rare cutaneous manifestation of leukemia. Clinical presentation of the disease differs among patients depending on types. LC can precede, follow, occur simultaneously with, or present in the absence of the systemic leukemia. Leukemic involvement of the skin may appear as initial manifestation of recurrence or dissemination of systemic disease. Here we report a case of a 32-year-old male patient known to have acute myeloid leukemia with multiple cutaneous lesions diagnosed as LC.

Clinical characteristics of 75 patients with leukemia cutis

Journal of Korean medical science, 2013

Leukemia cutis (LC) is defined as a neoplastic leukocytic infiltration of the skin. Few clinical studies are available on recent trends of LC in Korea. The purpose of this study was to analyze the clinical features and prognosis of LC in Korea and to compare findings with previous studies. We performed a retrospective study of 75 patients with LC and evaluated the patients' age and sex, clinical features and skin lesion distribution according to the type of leukemia, interval between the diagnosis of leukemia and the development of LC, and prognosis. The male to female ratio was 2:1, and the mean age at diagnosis was 37.6 yr. The most common cutaneous lesions were nodules. The most commonly affected site was the extremities in acute myelocytic leukemia and chronic myelocytic leukemia except for acute lymphocytic leukemia. Compared with previous studies, there was an increasing tendency in the proportion of males and nodular lesions, and LC most often occurred in the extremities....

Recurrent leukemia cutis in acute myeloblastic leukemia

1989

We report the case of a 64-year-old female with acute myeloblastic leukemia (French-American-British classification: M2) who developed two specific cutaneous manifestations during her illness. She presented with extensive cellulitis involving the face, neck, and upper chest wall. While the cellulitis resolved with antibiotic therapy, a fungating ulcerated nodule remained on the lower lip which proved to be leukemic on biopsy. Concomitant blood and bone marrow findings were diagnostic of acute myeloblastic leukemia. The lip lesion cleared with a course of chemotherapy. An erythematous macular rash subsequently developed over the lower trunk which was thought to be an allergic reaction to the penicillin treatment. However, biopsy results were consistent with leukemia cutis. A repeat bone marrow examination revealed excessive blasts. Our observations emphasize the various presentations of leukemia cutis and the need to biopsy any cutaneous lesion of unclear etiology in the setting of a...

B-Cell Acute Lymphoblastic Leukemia Presenting as Leukemia Cutis: A Case Report

Cureus, 2020

Leukemia cutis (LC) is a manifestation of leukemia with infiltration of the dermis, epidermis, or subcutis by malignant leukocytes resulting in papules, plaques, nodules, or ulcers. It is usually associated with acute and chronic myeloid leukemia as well as T-cell acute lymphoblastic leukemia (T-ALL) but is very rare in patients with B-cell acute lymphoblastic leukemia (B-ALL). We report a case of a 58-year-old Hispanic male who presented with a non-healing leg ulcer of three months along with patches on the face, left arm, and bilateral legs with white blood cell (WBC) count of 50800/mm 3 with 83% blasts, and flow cytometry findings of BALL. Punch biopsies from affected skin showed numerous dermal nodules composed of large atypical cells with open chromatin and prominent nucleoli. Immunohistochemical stains were consistent with BALL involving the skin and a diagnosis of LC was rendered. A high index of suspicion in relevant cases and prompt diagnosis is imperative to prevent any delays in appropriate therapy. Diagnosis in our case was aided by concurrent identification of BALL in the patient's peripheral blood. Since this information may not always be available, it is important to keep BALL in the differential any time there is a neoplastic infiltration of leukocytes in the dermis.

Clinical presentation of non-malignant diseases mimicking leukemia cutis: A report of two cases

Archivos Argentinos De Pediatria, 2023

The infiltration of leukemia cells into the skin, known as leukemia cutis, is a rare presentation of this disease and accounts for a diagnostic challenge. The main differential diagnoses include infections, other neoplastic diseases with skin involvement and histiocytic disorders, among others, as they entail different prognostic and therapeutic approaches. Here we describe two patients who were initially diagnosed with leukemia cutis, whose final diagnosis was of non-malignant diseases.