Histamine H2Receptor Antagonist Ranitidine Protects Against Neural Death Induced by Oxygen-Glucose Deprivation (original) (raw)

Cerebral ischemia results in significant cell death, primarily due to excessive glutamate release and receptor overactivation. Histamine (HA) has been implicated in mediating neuronal injury; however, its role, particularly through H2-receptors, remains poorly understood. This study investigates the effects of H2-receptor antagonists, specifically ranitidine, on cell death in an oxygen-glucose deprivation (OGD) model. Findings indicate that both pretreatment and post-treatment with ranitidine significantly reduces cell death and prevents the activation of caspase 3, suggesting a protective role against ischemic injury.