ISFET drawbacks minimization using a novel electronic compensation (original) (raw)

2004, Sensors and Actuators B-chemical

Ion sensitive field effect transistor (ISFET) and membrane field effect transistor (MEMFET) have some drawbacks related to: long-term drift, hysteresis and thermal drift. These factors limit the accuracy of ISFET/MEMFET based measurements systems, specially for continuous or long period measurements. Due to its accuracy, repeatability and easy-to-use features, electronic instrumentation systems are the best tools to design ISFET/MEMFET based measurement systems. A well-designed hardware and a qualified virtual instrumentation software are the key factors to overcome and compensate hysteresis, thermal and long-term drifts ISFET/MEMFET limitations. The paper is dedicated to show an instrumentation system designed to compensate long-term drift on ISFET/MEMFETs. First, this limitation is experimentally shown. As a consequence of it, an electronic hardware is designed to supply correct sensor voltage and current bias levels. On the other hand, an acquisition and control algorithm is implemented. The software acts over the hardware selecting appropriate voltage bias levels compensating sensor drifts. Experimental results demonstrate the effectiveness and feasibility of the instrumentation system proposed.

Sign up for access to the world's latest research.

checkGet notified about relevant papers

checkSave papers to use in your research

checkJoin the discussion with peers

checkTrack your impact

Novel voltage-controlled conditioning circuit applied to the ISFETs temporary drift and thermal dependency

Sensors and Actuators B-chemical, 2003

This paper describes a novel conditioning circuit applied to ion-sensitive field-effect transistors/membrane-ion-sensitive field-effect transistors (ISFETs/MEMFETs) sensors. The novel conditioning circuit allows the sensor polarization with the needed either voltage or current required in each application, thanks to two completely independent voltage-controlled blocks (current and voltage blocks). The control of the voltage block is the most critical point in our design because the voltage block maintains the sensor feedback stable, avoiding the thermal and temporary drifts of the sensor feedback. #

Design and Simulation of an Ion Sensitive Field Effect Transistor (ISFET) Readout Circuit, with Low Thermal Sensitivity

2018

Ion Sensitive Field Effect Transistor (ISFET) is one of the biological and/or chemical sensors compatible with the CMOS technology. The sensitivity of the ISFET is measured connecting the device to a readout circuit that provides an output voltage related to the threshold voltage shift according to the ion concentration. However, the influence of the temperature on the whole system (Electrolyte-ISFET-Readout circuit) is critical for proper processing. The proposed readout circuit tends to minimize the thermal sensitivity of the sensor circuit. The simulation was done using the AMI 1 µm CMOS process provided by MOSIS, while the Verilog-A was used to model a pH-ISFET behavior. Simulation results with 3 V supply voltage and a temperature range from 20 °C to 80 °C, shows a pH sensitivity of 40 mV/pH with thermal sensitivity less than 0.0005517 pH/°C. The coefficient of determination R2 is around 0.999984 at T = 20 °C and quantify the strength of the linear relationship.

TopSPICE Simulations for Temperature Compensation of ISFET/MEMFET Micro-Sensor

2014

In this work, an ISFET (Ion Sensitive Field Effect Transistor)/MEMFET (Membrane Field Effect Transistor) interface circuit with temperature compensation has been successfully designed and simulated. In each interface, we used the macro-model of ISFET/MEMFET based chemical sensors simulated in TopSPICE. The simulation results of the different sensing circuits of ISFET/MEMFETs for temperature compensation show that the readout configuration for ISFET/MEMFET sensors based on Wheatstone-Bridge connection is the most effective with a temperature drift 5×10 -6 mV/°C. Copyright © 2014 IFSA Publishing, S. L.

Electrical Characterization and Study of Current Drift Phenomena and Hysteresis Mechanism in Junctionless Ion-Sensitive Field-Effect Transistor

Silicon

A comprehensive study of the drain current drift mechanism and hysteresis phenomena in fabricated p-channel junctionless ion-sensitive field-effect transistor (JL-ISFET) has been investigated for the first time. The current drift measurements have been performed through transient analysis of drain current, under different pH and liquid-gate bias (V lg). Further, time-dependent gate-capacitance (C G) has also been analyzed to see the effect of hydroxyl ions (OH −) in the sensing film (Al 2 O 3). The hysteresis has also been investigated for different pH loop (7 → 3 → 7 → 11 → 7 and 7 → 11 → 7 → 3 → 7) and times (960s, 1500s, and 1920s). It has been observed that the drift of JL-ISFET occurs because of chemical modification of the sensing film, due to OH −. The proposed device exhibits threshold voltage sensitivity of 58.2 mV/pH that is near to the Nernstian limit. Further, the hysteresis width and maximum drain current drift are measured as ∼ 1.3 mV and 2.4 µA (∼ 75%), respectively.

An Integrated ISFETs Instrumentation System in Standard CMOS Technology

IEEE Journal of Solid-State Circuits, 2000

This paper describes an integrated ISFETs instrumentation system in a 0.18 m 1-poly-6-metal CMOS process. The chip is able to compute the average of CMOS ISFETs' threshold voltages by using an averaging array employing global negative current feedback. In addition, neither reference voltage nor current is required to set up the sigma-delta modulator because the internal signal is converted and processed in the frequency domain. The chip operates at 3.3 V for the analog blocks and the digital input/output blocks, and at 1.8 V for the core digital logic. It achieves 8 bits accuracy under 80 W static power consumption. The die area is 2.6 mm 2 .

Low frequency noise and drift in Ion Sensitive Field Effect Transistors

Sensors and Actuators B: Chemical, 2000

Ž. Ion Sensitive Field Effect Transistors ISFETs are currently produced commercially and promise to become the platform sensors for important biomedical applications. The drift in ISFETs is still an important inherent problem that prevents its application to accurate in Ž. vivo measurements. The present paper presents measurements of the drift and the drain current power spectral density PSD of pH ISFETs in the very low frequency range from 5 mHz to 10 kHz. The measurements have been performed in buffer solutions with pH 4, 7 and 10, at room temperature. Above a corner frequency, the measured spectra correspond to 1rf noise introduced by fluctuations at the channel current. Below this corner frequency that depends on the magnitude of the drift, the measured spectra correspond to 1rf 2. The observed corner frequency is ; 1 Hz for a drift of 2 mVrh and shifts to frequencies below 0.01 Hz for a drift of 0.1 mVrh. The measured drift is correlated to leakage currents as well as temperature fluctuations and the inherent behaviour of the ISFET. A method for quality evaluation based on frequency behaviour is introduced.

Temperature compensation electronics for ISFET readout applications

IEEE International Workshop on Biomedical Circuits and Systems, 2004.

This paper presents temperature compensation electronics for Ion Sensitive Field Effect Transistor (ISFET) sensors. It consists of a bridgetype floating-source ion sensing circuit and a VT extractor centigrade temperature sensor accompanied with a temperature coeilicient (TCF) cancellation method, Using LabWEW packages has developed an extended measurement system including compensation algorithms programming. Experimental results show that the temperature dependence of the Sif14-gate ISFET sensor improved from SmVPC to near OmVPC with the proposed temperature compensation circuitry. Thiis system allows a wide range of high accurate pH-level measurements. Tbe method of temperature compensation may also be valid for other biosensors or bioFETs.

New ISFET interface circuit design with temperature compensation

Microelectronics Journal, 2006

An integrated and new interface circuit with temperature compensation has been developed to enhance the ISFET readout circuit stability. The bridge-type floating source circuit suitable for sensor array processing has been proposed to maintain reliable constant drain-source voltage and constant drain current (CVCC) conditions for measuring the threshold voltage variation of ISFET due to the corresponding hydrogen ion concentration in the buffer solution. The proposed circuitry applied to Si 3 N 4 and Al 2 O 3-gate ISFETs demonstrate a variation of the drain current less than 0.1 mA and drain-source voltage less than 1 mV for the buffer solutions with the pH value changed from 2 to 12. In addition, the scaling circuitry with the V T temperature correction unit (extractor) and LABVIEW software are used to compensate the ISFET thermal characteristics. Experimental results show that the temperature dependence of the Si 3 N 4-gate ISFET sensor improved from 8 mV/1C to less than 0.8 mV/1C.

Novel constant current driver for ISFET/MEMFETs characterization

Sensors and Actuators B: Chemical, 2001

In the present work a new constant current driver for ISFETs and MEMFETs sensors has been developed. The proposed circuit maintains the ISFET/MEMFET operation point at constant drain±source current and voltage. The combination of some programmable current sources and an appropriate selection of a simple precision resistor allow a good ISFET/MEMFET polarization. The use of operational ampli®ers with low offset and drift are required to provide the buffering function needed by the sensor. #

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.