CLINICAL STUDY DONE BY DOCTOR OF PHARMACY STUDENTS ON THE ADVERSE DRUG REACTIONS IN CANCER PATIENTS IN GOVERNMENT HEAD QUARTERS, KRISHNAGIRI (original) (raw)
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Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 Journal of Medical Pharmaceutical and Allied Sciences, V 7-I 5, 767. July 2018, 1064-1069, 2018
Pharmacovigilance plays a vital role in ensuring that cancer patients receive appropriate medical products that are safe and effective, but very few studies has been done in past on Clinical oncology setup. Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. ADRs leading to hospitalization or occurring during hospital stay contribute significantly to cancer patient morbidity and mortality as well as representing an additional cost for healthcare systems. Chemotherapy, a multimodal approach to oncological treatment, involves highly complex regimens and hence accounts to high susceptibility toward ADRs. The study was conducted in the North eastern part of Tamilnadu with less literacy rate and high rate of incidence in sexually transmitted disease. Understanding the underlying mechanisms by the Clinical Pharmacist is critical for clinical diagnosis and management of different ADRs at its early stage in oncology departments. The present study was conducted to assess the chemotherapy induced adverse drug reactions in patients of cancer of oncology department patients in Government Head Quarters Hospital, Krishnagiri and Tamilnadu for a period of 6 months from December 2015 to May 2016.
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 , 2018
Journal of Medical Pharmaceutical And Allied Sciences www.jmpas.com ISSN NO. 2320 - 7418 DOI 10.22270/ujpr.v7i5.767 Journal of Medical Pharmaceutical and Allied Sciences, V 7-I 5, 767. July 2018, 1064-1069Journal of Medical Pharmaceutical and Allied Sciences, V7-I7, 789. October 2018, 2000-2013 , 2018 Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. ADRs leading to hospitalization or occurring during hospital stay contribute significantly to cancer patient morbidity and mortality as well as representing an additional cost for healthcare systems. Chemotherapy, a multimodal approach to oncological treatment, involves highly complex regimens and hence accounts to high susceptibility toward ADRs. In the present scenario the death rate due to cancer is gradually increasing. It is one of the leading causes of death in adult aged under 65 years. It was widely noted that 80-90% of the human cancer may be attributable to environmental and life style factors. Estimations reveal that in the year 2000 over 6 million people died due to cancer and ADR is considered to contribute to the fatality rate. So there is a need to create awareness among the physicians towards ADR monitoring in cancer patients .Our present study is to analyze the pattern of Adverse Drug Reaction occurring in cancer patients treated with anticancer agents and to suggest useful interventions to reduce the incidence of ADR. The aim of the present study is to assess the adverse drug reactions in male and female cancer patients in Government Head Quarters, Krishnagiri. This clinical relevant study strictly states that the intervention of a clinical pharmacist in treatment team, which can limit, predict, monitor, prevent and treat the occurrence of ADR on ANAs. The study was conducted in the North eastern part of Tamilnadu with less literacy rate and high rate of incidence in sexually transmitted disease.
The study is the assessment of Adverse drug reaction in a Cancer Care Center. We have conducted the prospective study to analyse the ADR The study population consisted of 178 patients in total. Among them 59% (n=105) of the patients were females. On classifying the patients based on age 33.15% (n=59) of the patients were of age group 60-69. From the total prescription 37.64% (n=67) of the diagnosis was concerned with the reproductive system and in 28.65% (n=51) of the cases the site of tumor was the cervix. As a part of the chemotherapy the patients were prescribed with various classes of anti-cancerous agents. About 67.97% (n=121) alkylating agents were preferred. And most frequently used anti-cancer drug was 5-FU. In 23.59% (n=42) of patients with a combination cisplatin + 5-FU was prescribed. 34.83% (n= 62) of patients had been prescribed with quinolones and 19.66% (n=35) of cases were given with ofloxacin. The prescriptions contained drugs other than anti-cancer agents like nutritional supplements. 35.39% (n=63) of the prescriptions were prescribed with Iron supplements. On classifying the ADRs found according to Wills & Brown classification of ADR assessment, 45.89% of the ADRs were of Type A(Augmented reaction) the chemotherapeutic drugs have a narrow therapeutic index and the dosage needed to achieve a therapeutic response usually proves toxic to the body’s rapidly proliferating cells. Early modifications in dosage regimen of chemotherapeutic agents may minimize the hazardous ADRs. Through pharmacist intervention in the adjustment of dosage regimen and supportive care maximum benefits can be gained by the patients because supportive care improves patient comfort and improves quality of life. Keywords: ADR, Pharmacist Intervention, Supportive care.
International Journal of Research in Medical Sciences
Background: The present study was undertaken to analyse the clinical spectrum, pattern of ADR reported, most common suspected drugs, timing of reporting of suspected ADR, outcome, severity and causality assessment of adverse drug reactions among oncology patients reported at our ADR monitoring Centre. Methods: The descriptive cross-sectional study was carried out for two months in the oncology department of a tertiary care rural hospital. ADR reporting form Version 2.4 was used for recording information of all patients of any gender and age who were suspected cases of adverse drug reactions receiving chemotherapy. Results: Total 83 ADRs were reported within the duration of two months. The number of males and females were 21 and 62, respectively with mean age 56.9±11.6 years for males and 59.6±8.8 years for females. The age group most commonly reported with suspected ADR was 61-70 years (28.9%). Of the 83 ADR reported, the most common suspected drug was Paclitaxel (47, 56.6%). The mo...
Journal of Medical Pharmaceutical And Allied Science, 2018
Adverse drug reactions (ADRs) are an important clinical issue and a serious public health risk. ADRs leading to hospitalization or occurring during hospital stay contribute significantly to cancer patient morbidity and mortality as well as representing an additional cost for healthcare systems. Chemotherapy, a multimodal approach to oncological treatment, involves highly complex regimens and hence accounts to high susceptibility toward ADRs. In the present scenario the death rate due to cancer is gradually increasing. It is one of the leading causes of death in adult aged under 65 years. It was widely noted that 80-90% of the human cancer may be attributable to environmental and life style factors. Estimations reveal that in the year 2000 over 6 million people died due to cancer and ADR is considered to contribute to the fatality rate. So there is a need to create awareness among the physicians towards ADR monitoring in cancer patients .Our present study is to analyze the pattern of Adverse Drug Reaction occurring in cancer patients treated with anticancer agents and to suggest useful interventions to reduce the incidence of ADR. The aim of the present study is to assess the adverse drug reactions in male and female cancer patients in Government Head Quarters, Krishnagiri. This clinical relevant study strictly states that the intervention of a clinical pharmacist in treatment team, which can limit, predict, monitor, prevent and treat the occurrence of ADR on ANAs. The study was conducted in the North eastern part of Tamilnadu with less literacy rate and high rate of incidence in sexually transmitted disease.
journal of medical science and clinical research
Background: Cancer, a term that elicits a shock in the nerve endings of every individual touches every country in the world. Material and Method: It was a prospective observational study. The study was carried out between November 2015 to April 2016 conducted in medical Oncology & Radiation Oncology Department in P.B.M. hospital and associated group of hospital, Bikaner. Result: female 43(252) were more affected by ADR as compared to male patients 34 (164). anaemia (14.42%) was the most common ADR followed by Vomiting (10.34%) and Nausea (9.13%). Conclusion: Chemotherapeutic drugs have a narrow therapeutic index and the dosage needed to achieve a therapeutic response usually proves toxic to the body's rapidly proliferating cells.
Journal of Young Pharmacists, 2017
Objective: To evaluate the pattern of adverse drug reactions (ADRs) reported in cancer patients receiving anticancer drugs in an adverse drug reaction monitoring centre (AMC). Methods: The anticancer drug related ADRs received in AMC through spontaneous reporting and active surveillance methods from January 2014 to June 2016 were analyzed for demographic profile, organ system and department wise distribution of ADRs, common ADRs encountered, drugs responsible for causing ADRs, ADRs reported by healthcare professionals, number of ADR/ ADRs developed per patient and causality assessment of reported ADRs. Descriptive statistics were used for analysis and the values were expressed in numbers and percentages. Results: 2209 ADRs were reported from 1869 patients comprising of 764 males (40.88%) and 1105 females (59.12%). In our study, the most common ADRs observed were anemia (12.68%), neuropathy (11.18%) and neutropenia (6.07%). Causality assessment of ADRs by WHO-UMC causality scale revealed that 90.9% of ADRs were possible followed by 4.48% probable and 2.39% possible. The most common organ system wise classified ADRs were blood (24.22%) related reactions followed by gastrointestinal system (14.17%) related adverse effects. The most common drugs associated with ADRs were imatinib (13.94%) followed by docetaxel (9.55%), gemcitabine (8.56%) and paclitaxel (7.38%). Amidst 1869 patients, 301(13.63%) patients had developed two ADRs while 39 (1.76%) patients experienced three ADRs. Conclusion: The average ADR encountered per patient due to anticancer drug was about 1.18 in this study. Anemia, neuropathy and neutropenia were the most common ADRs reported.
International Journal of Basic & Clinical Pharmacology
Background: Globally cancer is the leading cause of morbidity and mortality with annual death rate of 12%. According Indian Council of Medical Research, more than 1300 Indians die every day due to cancer. Chemotherapy is one of the multimodal approaches for treatment of cancer and regimens are much complex and cancer patients are more susceptible to adverse drug reaction with little tolerance due to diminished immunity. The present study was done to evaluate the prevalence of various adverse drug reactions with different cancer chemotherapy regimens, their nature and severity as well as their causality assessment as per WHO scale.Methods: This prospective observational study was conducted from July 2015 to June 2016. Patients receiving cancer chemotherapy from regional cancer centre, Cuttack were observed during the study period for the adverse drug reactions. Those ADRs were analysed for causality assessment, severity and preventability.Results: It was observed that after the initi...
Cureus, 2023
Introduction: Anticancer agents are responsible for a majority of adverse drug reactions (ADRs) in cancer patients. ADR reporting with anticancer drugs is very rare in India due to the lack of awareness and knowledge about the Pharmacovigilance Programme of India. Hence, this study was done to assess the pattern of ADRs with anticancer agents in cancer patients and to increase awareness about ADR monitoring among healthcare professionals. Materials and methods: This is an observational, retrospective and non-interventional study conducted in an ADR monitoring centre (AMC) in Govt.