Fibrinolysis associated with human neoplasia: Production of plasminogen activator by human tumours (original) (raw)

1977, International Journal of Cancer

The plasminogen-dependent fibrinolytic activity of several human tumours has been studied. The following neoplastic tissues, which were obtained from cancer patients by either surgery or biopsies, were examined: cervical, mammary. prostatic, ovarian, lung carcinomas, melanoma, basalioma. Fibrinolysis was measured in lysates either of tumour tissue specimens or of respective cell cultures. This measurement was based on release of radioactivity from '2s1-fibrin-coated Petri dishes. All examined tumours showed elevated levels of plasminogen-dependent fibrinoiytic activity. However, normal control tissues had little or no activity. These results indicate that the fibrinolyds might be useful in differentiating between malignant and normal tissues, Les auteurs ont Btudi6 I'activit6 fibrinolytique plasminogbe-dependante de plusieurs tumeurs humaines. 11s ont examine les tissus n6oplasiques suivants, obtenus h la suite d'interventions chirurgicales ou de biopsies effectuees sur des sujets cancireux: cancers du col uterin, du sein, de la prostate, de I'ovaire, du poumon, m6lanome, basaliome. La fibrinolyse a i t 6 mesuree dans les lysats des sp6cimens de tissus tumoraux ou des cultures respectives. Cette mesure 6tait fondQe sur la radioactivit6 d6gagie par les boites de Petri enduites de fibrine-'251. Pour toutes les tumeurs examinees, I'activit6 fibrinolytique plasminoghedipendante etait 6lev6e. Par contre, pour lei tissus normaux, elle Ctait faible ou nulle. Ces r6sultats indiquent que la fibrinolyse pourrait servir a distinguer les tissus canchreux des tissus normaux.