Effect of exenatide twice daily according to different meal schedules on glycemic control and variability in patients with type 2 diabetes mellitus (original) (raw)

ABSTRACT Objective: To assess the effect of exenatide twice daily ac- cording to different meal schedules on glycemic control and variability in patients with type 2 diabetes mellitus. Materi- als and methods: A randomized, open clinical trial was per- formed in 18 adults with type 2 diabetes mellitus who were overweight or obesity and inadequate glycemic control with metformin as monotherapy. Fasting glucose was < 12 mmol/l and glycated hemoglobin A1c between 7-9%. All patients received exenatide (5 μg twice daily) subcutaneously for four weeks and continued taking metformin at the same dose throughout the study. A randomized distribution of six sub- jects was conducted to each of the following pre-prandial times of application of exenatide: (i) breakfast and lunch, (ii) breakfast and dinner, or (iii) lunch and dinner. At the begin- ning and four weeks later, glucose concentrations were mea- sured every hour during a 24-hour period. Area under the curve of glucose and glycemic variability according to the mean amplitude of glycemic excursions was calculated.