Effectiveness of a Bacillus megaterium, as a probiotic in Salmonella typhimurium induced infection in rats (original) (raw)
2015, Journal of Pharmacy Research
Background: Bacterial infections are common despite prophylactic administration of antibiotics. The widespread use of antibiotics in patients has contributed to the emergence of multiresistant bacteria. A restricted use of antibiotics must be followed in most clinical situations. In patients there are several reasons for an altered microbial flora in the gut in combination with an altered barrier function leading to an enhanced inflammatory response. Several experimental and clinical studies have shown that probiotics may reduce the number of potentially pathogenic bacteria and restore a deranged barrier function. Methods: In this study Wistar albino rats were chosen to evaluate the effectiveness of Probiotic therapy by inducing them with infection using known bacterial pathogen Salmonella typhimurium and Treatment with common probiotics such as Bacillus megaterium.After the induction and treatment period the samples (Blood, Serum and tissues) were analyzed for haematological parameters, Biochemical markers and histopathological nature by comparing with non-induced and induced controls. Results and Discussion: The haematological, biochemical and the histopathological parameters studied were comparatively abnormal in induced animals and also they were very close to normal range in rats induced and treated with probiotics. The effectiveness was good for Bacillus megaterium. The reason behind that may be the ways and means how the organisms accommodate and accustom to the intestinal environment. Conclusion: The study has clearly indicated that probiotics could effectively be used for various ailments induced by pathogenic microorganisms.
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