Eosinophilic Gastroenteritis and Colitis with Elevated Level of Serum IgA: A Case Report (original) (raw)
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An Unusual Presentation of Eosinophilic Gastroenteritis: Case Report and Literature Review
The Open Gastroenterology Journal, 2012
Eosinophilic gastroenteritis [EGE] is a rare disease of the gastrointestinal tract characterized by eosinophilic infiltration of the bowel wall and variable gastrointestinal manifestation. The signs and symptoms of EGE are related to the extent of bowel involved with eosinophilic infiltration whether mucosa; muscle; and / or subserosa. Peripheral eosinophilia may or may not be present. Diagnosis requires a high index of suspicion and exclusion of other causes of peripheral eosinophilia. We report a case of a young woman who presented with recurrent abdominal pain and ascites. Diagnosis of EGE was made based on clinical, laboratory, radiological and histological criteria. The patient demonstrated overlap between different subtypes of EGE and had an excellent response to steroid treatment.
Eosinophilic gastroenteritis: a review
2007
Eosinophilic gastroenteritis is a rare benign disease characterized by tissue eosinophilic infiltration that may involve several digestive tract layers. Also known as allergic, or eosinophilic allergic, gastroenteropathy, it usually involves the stomach and small intestine: rarely the colon. It may or may not be accompanied by higher counts of eosinophils in the peripheral blood. The main clinical manifestations depend on the site affected. It has been classified according to clinical and pathological features, and the symptoms depend on the patient's immunological response to several cytokines released by eosinophils. Because of lack of understanding of the etiology and triggering factors, treatment is based mainly on corticosteroids; although other drugs acting on the immune system have been tested, the results are not always satisfactory. This review focuses on the epidemiology, pathophysiology, clinical features, and treatment of this hitherto under-diagnosed disease.
Eosinophilic gastroenteritis in an immunosuppressed patient: a case report
International Journal of Advances in Medicine, 2018
Eosinophilic gastroenteritis is a rare disease that is characterized by Eosinophil infiltration in one or multiple segments of the gastrointestinal tract. The etiology of this condition remains unknown. Eosinophilic gastroenteritis has heterogeneous clinical manifestations that depend upon the location and depth of infiltration in the gastrointestinal tract, and eosinophilia may or may not be present. This article reports a case of Eosinophilic Gastroenteritis in a 57 years old retroviral male patient, who presented with chronic diarrhea, bilateral pedal edema and eosinophilia. Ultimately, the diagnosis of eosinophilic gastroenteritis was clinched. The rare character of eosinophilic gastroenteritis and its varied clinical presentations often lead to delayed diagnosis and complications. Case reports may help to disseminate knowledge about the disease, thereby increasing the likelihood of early diagnosis and intervention to prevent complications.
EOSINOPHILIC COLITIS: A RARE CASE REPORT AND REVIEW OF THE LITERATURE
International Journal of Advanced Research (IJAR), 2022
Primary eosinophilic gastrointestinal disease (EGID) is a rare inflammatory gastrointestinal disorder characterized by eosinophil infiltration in the gut. EGIDs are sub-grouped as eosinophilic esophagitis (EE), eosinophilic gastroenteritis (EG), and eosinophilic colitis (EC). The least frequent manifestation of EGIDs is EC which affects newborns and young adults. An 18-year-old male patient was admitted complaining of recurrent epigastric and lower abdominal pain, abdominal distension, vomiting, bloody diarrhea, and weight loss for a long time. Laboratory investigations performed showed a white blood cell (WBC) count of 14.5 × 109/L, with 62.1% neutrophils, 22.4% lymphocytes, 13.2% monocytes, 28.2% eosinophils, 0.1% basophils, and hemoglobin (HGB) level of 6.3 g/dL. Stool examination was positive in the helicobacter pylori test and occult blood. Colonoscopic biopsy showed active colitis with eosinophilia. We recommended corticosteroid treatment to the patient. With prednisolone treatment of 20 mg 2 times per day, the clinical features resolved.
Unusual presentations of eosinophilic gastroenteritis: Two case reports
The Turkish Journal of Gastroenterology, 2014
Eosinophilic gastroenteritis is a rare disease that is characterized by eosinophil infiltration in one or multiple segments of the gastrointestinal tract. The etiology of this condition remains unknown. Eosinophilic gastroenteritis has heterogeneous clinical manifestations that depend upon the location and depth of infiltration in the gastrointestinal tract, and eosinophilia may or may not be present. This article reports two cases of eosinophilic gastroenteritis. The first is that of a 49-year-old woman with abdominal pain, ascites, eosinophilia, and a history of asthma. The second case is that of a 69-year-old male with a history of loss of appetite, belching, postprandial fullness, heartburn, and a 5-kilogram weight loss over a period of 9 months; ultimately, the patient was diagnosed with a gastric outlet obstruction due to pyloric stenosis. The rare character of eosinophilic gastroenteritis and its varied clinical presentations often lead to delayed diagnoses and complications. Case reports may help to disseminate knowledge about the disease, thereby increasing the likelihood of early diagnosis and intervention to prevent complications.
Eosinophilic gastroenteritis: clinical experience with 15 patients
World journal of gastroenterology : WJG, 2003
To evaluate the clinic features of eosinophilic gastroenteritis and to examine the diagnosis, treatment, long-term outcome of this disease. Charts with a diagnosis of eosinophilic gastroenteritis from 1984 to 2002 at Mackay Memorial Hospital were reviewed retrospectively. There were 15 patients diagnosed with eosinophilic gastroenteritis. The diagnosis was established in 13 by histologic evaluation of endoscopic biopsy or operative specimen and in 2 by radiologic imaging and the presence of eosinophilic ascites. All the patients had gastrointestinal symptoms and 12 (80%) had hypereosinophilia (absolute eosinophil count 1,008 to 31,360/cm3). The most common symptoms were abdominal pain and diarrhea. Five of the 15 patients had a history of allergy. Seven patients had involvement of the mucosa, 2 of muscularis, and 6 of subserosa. One with a history of seafood allergy was successfully treated with an elimination diet. Another patient improved spontaneously after fasted for several day...
A Rare Case of Eosinophilic Colitis
2020
Background: Eosinophilic Colitis (EC) is the least wellunderstood subgroup of the Primary Eosinophilic Gastrointestinal Diseases (EGIDs), a spectrum of disorders characterized by pathologic eosinophilic infiltration along the gastrointestinal tract, in the absence of other causes of eosinophilia. It is currently regarded as a diagnosis of exclusion. Case Presentation: This is a case report of EC, where a 47-year-old gentleman presented with chronic diarrhoea, mild abdominal pain, weight loss and intermittent right forearm swelling. Significant eosinophilia (7.63%) was identified and colonic biopsy demonstrated focal superficial active inflammation with markedly increased eosinophilic infiltration in the lamina propria. The work up for hyper-eosinophilia was otherwise negative. Once oral corticosteroids were initiated, his symptoms and eosinophil count improved. Conclusion: The scarcity of the reporting for EC could be due to its under-diagnosis. We suggest that all cases of chronic ...
Case Reports in Medicine
Background. Eosinophilic gastroenteritis (EGE) is an uncommon disease characterized by eosinophilic infiltration of the digestive tract, which occurs due to an uncertain aetiology. Although autoimmune diseases can later present as EGE, it is unusual for EGE to have positive autoimmune antibodies without the presence of an overt autoimmune disease. Case presentation. We report a 38-year-old previously healthy man who presented with abdominal discomfort and loose stools with pleural and peritoneal effusions progressing over several weeks. His investigations revealed severe eosinophilia in peripheral blood and ascitic fluid, and a laparoscopic full-thickness biopsy from the ileum demonstrated infiltration of eosinophils in all three layers of the intestine. There were no clinical features or investigations suggestive of parasitic disease, other diseases associated with eosinophilia, or autoimmune disease. Further investigations showed a highly positive ANA, positive p-ANCA, but did not...
Eosinophilic gastroenteritis presenting with duodenal obstruction and ascites
Annals of the Academy of Medicine, Singapore, 2011
Eosinophilic gastrointestinal disorders or eosinophilic digestive disorders encompass a spectrum of rare gastrointestinal disorders that includes eosinophilic esophagitis, eosinophilic gastroenteritis, and eosinophilic colitis. Eosinophilic gastroenteritis is a rare inflammatory disease characterized by eosinophilic infiltration of the gastrointestinal tract. The clinical manifestations include anemia, dyspepsia, and diarrhea. Endoscopy with biopsy showing histologic evidence of eosinophilic infiltration is considered definitive for diagnosis. Corticosteroid therapy, food allergen testing, elimination diets, and elemental diets are considered effective treatments for eosinophilic gastroenteritis. The treatment and prognosis of eosinophilic gastroenteritis is determined by the severity of the clinical manifestations. We describe a 24-year-old woman with eosinophilic gastroenteritis presenting as epigastric pain with a history of severe iron deficiency anemia, asthma, eczema, and allergic rhinitis, and we review the literature regarding presentation, diagnostic testing, pathophysiology, predisposing factors, and treatment recommendations. (
Eosinophilic gastroenteritis: Approach to diagnosis and management
World Journal of Gastrointestinal Pharmacology and Therapeutics, 2016
inflammatory disorder that predominantly affects the stomach and the small intestine. The disease is divided into three subtypes (mucosal, muscular and serosal) according to klein's classification, and its manifestations are protean, depending on the involved intestinal seg ments and layers. Hence, accurate diagnosis of EGE poses a significant challenge to clinicians, with evidence of the following three criteria required: Suspicious clinical symptoms, histologic evidence of eosinophilic infiltration in the bowel and exclusion of other pathologies with similar findings. In this review, we designed and applied an algorithm to clarify the steps to follow for diagnosis of EGE in clinical practice. The management of EGE represents another area of debate. Prednisone remains the mainstay of treatment; however the disease is recognized as a chronic disorder and one that most frequently follows a relapsing course that requires maintenance therapy. Since prolonged steroid treatment carries of risk of serious adverse effects, other options with better safety profiles have been proposed; these include budesonide, dietary restrictions and steroidsparing agents, such as leukotriene inhibitors, azathioprine, anti-histamines and mast-cell stabilizers. Single cases or small case series have been reported in the literature for all of these options, and we provide in this review a summary of these various therapeutic modalities, placing them within the context of our novel algorithm for EGE management according to disease severity upon presentation.