Solvent assisted size effect on AuNPs and significant inhibition on K562 cells (original) (raw)

Anticancer potential of gold nanoparticles (AuNPs) using a battery of in vitro tests

Nanotechnology Reviews

This study synthesized gold nanoparticles (AuNPs) using a facile microwave-assisted chemical route and evaluated them as potential anticancer candidates against breast and colon cancer cell lines. Numerous spectral characterization tools were used to study the optical properties, structure, and morphology of the prepared AuNPs. UV-Vis spectroscopy showed a characteristic peak at 517 nm, which confirms the formation of AuNPs. The crystalline structure of NPs was studied by X-ray diffraction, and the NPs’ shape and size were calculated with Field emission transmission electron microscopy. The synthesized AuNPs were found to be uniform in size in the range of 2–6 nm. A variety of biological tests, including MTT, scratch, real time polymerase chain reaction (RT-PCR), and comet assays were adopted to assess the anticancer potential of these AuNPs in the studied cancer cell models. The findings suggested a cell-dependent cytotoxicity of AuNPs. Different cell viability of 40.3 and 66.4% we...

Progress in research on gold nanoparticles in cancer management

Medicine, 2019

Introduction: The rapid advancement of nanotechnology in recent years has fuelled burgeoning interest in the field of nanoparticle research, particularly its application in cancer management. At present, there seems to be heightened interest in the application of gold nanoparticles (AuNPs) to the management of cancer, encompassing diagnosis, monitoring, and treatment. AuNPs could be used as drug delivery agents that target cancer cells or in gene therapy. These efforts are undertaken in the hope of revolutionizing current methods and strategies for cancer treatment. This review will focus on the current applications of AuNPs in cancer management. Objectives, data sources, study appraisal and synthesis methods, results: objectives, data sources, study eligibility criteria, participants, and interventions, study appraisal and synthesis methods, results are not required, as the study will be a literature review. Just introduction, ethics and dissemination, and conclusion are applicable. Ethics and dissemination: Ethical approval and informed consent are not required, as the study is a literature review and does not involve direct contact with patients or alterations to patient care. Conclusion: AuNPs have many properties that are of great value for the diagnosis and treatment of tumors. AuNPs are small in size and can penetrate widely and deposit on the tumor site, bind to many proteins and drugs, target delivery drugs, and have good biocompatibility. The application of AuNPs in the diagnosis and treatment of tumors is very considerable. In the near future, AuNPs will certainly play an important role in the treatment of tumors. Abbreviations: AuNCs = gold nanoclusters, AuNPs = gold nanoparticles, AuNRs = gold nanorods, AuNSs = gold nanoshells, CTAB = cetyltrimethylammonium bromide, EGFR = epidermal growth factor receptor, EpCAM = epithelial cell adhesion molecule, HER-2 = human epidermal growth factor receptor-2, MTX = methotrexate, PEG = polyethylene glycol, PET = positron emission tomography.

Application of Gold Nanoparticle-Based Materials in Cancer Therapy and Diagnostics

ChemEngineering

Several metal nanoparticles have been developed for medical application. While all have their benefits, gold nanoparticles (AuNPs) are ideal in cancer therapy and diagnosis as they are chemically inert and minimally toxic. Several studies have shown the potential of AuNPs in the therapeutic field, as photosensitizing agents in sonochemical and photothermal therapy and as drug delivery, as well as in diagnostics and theranostics. Although there is a significant number of reviews on the application of AuNPs in cancer medicine, there is no comprehensive review on their application both in therapy and diagnostics. Therefore, considering the high number of studies on AuNPs’ applications, this review summarizes data on the application of AuNPs in cancer therapy and diagnostics. In addition, we looked at the influence of AuNPs’ shape and size on their biological properties. We also present the potential use of hybrid materials based on AuNPs in sonochemical and photothermal therapy and the...

Gold Nano Particles of Cancer Treatment: A Review

American Journal of PharmTech Research

Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitise. Cancer is the disease caused by an uncontrolled division of abnormal cells in a part of the body. In this review some various nanotechnology is found the 10 new technique and treated with all the cancer treatment is beneficial compare to other cancer therapy. Will the synthesis of various gold nano particles and find out the gold nano shells, gold nano cages, gold colloidal nano spheres. Then Nanoparticles can be used to target bio-markers or antigens that are highly specific to Cancer cells. This gold nano particles using the therapy Rheumatoid arthritis, Alzheimer's disease, Cancer detection. The introduces to the cancer diseases, nano particles techniques, cancer therapy, then various types of the gold nano particles, properties of cancer cells, future scope of cancer treatment, applications, background of cancer treatment will be discussed.

Role of gold and silver nanoparticles in cancer nano-medicine

Artificial Cells, Nanomedicine, and Biotechnology

Development of nanoparticles (NPs) as a part of cancer therapeutics has given rise to a new field of researchcancer nanomedicine. In comparison to traditional anti-cancer drugs, NPs provide a targeted approach which prevents undesirable effects. In this communication, we have reviewed the role of gold and silver NPs (AgNPs) in the cancer nanomedicine. The preparation of gold NPs (AuNPs) and AgNPs can be grouped into three categoriesphysical, chemical and biological. Among the three approaches, the biological approach is growing and receiving more attention due to its safe and effective production. In this review, we have discussed important methods for synthesis of gold and AgNPs followed by techniques employed in characterization of their physicochemical properties, such as UV-visible spectroscopy, electron microscopy (TEM and SEM) and size and surface analysis (DLS). The mechanism of formation of these NPs in an aqueous medium through various stagesreduction, nucleation and growth has also been reviewed briefly. Finally, we conclude our review with the application of these NPs as anti-cancer agents and numerous mechanisms by which they render cancer cell toxicity.

IN VITRO CYTOTOXIC STUDY FOR COMPARISON BETWEEN EFFECT OF GOLD AND SILVER NANOPARTICLES AGAINST CANCER CELLS LINES

Article , 2019

Cancer is a large problem in the world, so the traditional treatment is not efficient in eradication the body from cancer cells. Recently, Nanotechnology in medicine involves applications of nanoparticles currently under development, especially the nobel elements such as gold and silver. In the present study, we investigated the effects of AgNPs and AuNPs on cytotoxicity of two cell lines Hepatocyte cancer cell line for mice (HC) and breast cancer cell line for human (MCF-7), Five concentration (0.625-10) μg were used from each particle and for each cell line for comparison between the effect of AgNPs and AuNPs. The study reveals that Au NPs and Ag NPs have effect on this cell line but the AuNPs have more effect than the Ag NPs, so the effect is related to concentration and cell type-dependent manner.