Endorphin: Opiate receptor-binding activity of synthetic analogs modified in the enkephalin segment in rat brain membrane and neuroblastoma x glioma hybrid cell (original) (raw)

International Journal of Peptide and Protein Research, 2009

Abstract

The potency of a series of synthetic analogs of β-endorphin in inhibiting binding of [3H2-Tyr27]-βh-endorphin to either rat brain membranes or neuroblastoma x glioma hybrid cells (NG108–15) has been determined and compared with the previously determined analgesic potency. There is a very good correlation between inhibitory potency in membranes and cells, but the correlation between analgesic potency and inhibitory potency in either membranes or cells is not as good.

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