An Overview of Nasal polyps and its pathogenesis, commodities and treatment (original) (raw)

Study of Nasal Polyps in a Tertiary Care Hospital

International Journal of Research in Pharmaceutical Sciences, 2020

Nasal polyps are macroscopic oedematous lesions in the nose openings are the most common problem of the patients. Main causes of the polyps are due to in lammatory conditions and allergy. An association with asthma, aspirin sensitivity and cystic ibrosis was seen in the population. The main objectives of medical treatment of nasal polyps are to eliminate or reduce the size of the polyps thereby improving the symptoms of rhinitis and breathing. The clinical characteristics and treatment pattern among the 125 patients having nasal polyps was analyzed by a retrospective, observational study using patient’s medical records and hospital data management system. Males predominated in thepresent study (64.8%)andmajority of thepatientswere in the age group of 41-60 years (44%). Most of the patients suffered from sinonasal polyposis (76.8%)with themain symptombeingnasal block (88.8%). Most of thepolyps were of the in lammatory origin (53.6%). Asthma and rhinitis were observed in 11% patients....

Chronic rhinosinusitis patient with nasal polyps at Dr. Soetomo General Academic Hospital Center

Bali Medical Journal, 2022

Background: Nasal polyps are benign chronic inflammatory masses with epithelial tissues of the nasal mucosa and paranasal sinuses. The clinical diagnosis is made based on sinonasal symptoms for more than three months and the presence of polyps in the nasal cavity. The classification of nasal polyps based on the histopathological structure is divided into three types, i.e., oedematous, eosinophilic polyps, inflammatory polyps, and chronic seromucous inflammatory polyps. This study aims to describe the profile of patients with nasal polyps at Dr. Soetomo Public Hospital Surabaya. Methods: This study applied a descriptive method with a retrospective approach by obtaining data from the medical records of the outpatient unit in the Ear, Nose, Throat, and Head-Neck (ENT-HN) Department of Dr. Soetomo Public Hospital Surabaya for the period January 2017-December 2018 based on age, gender, clinical symptoms, symptoms duration, polyp types, location of nasal polyp, and comorbidities. Results: The number of patients with nasal polyps was slightly more in women, as many as 13 patients or 52%, mostly aged 51-60 years old, amounting to 11 patients or 44%. The most common clinical symptom experienced by patients was nasal obstruction, as many as 24 patients or 96%. Patients who experienced symptom duration for one to three years before treatment amounted to 13 patients or 52%. Patients with histopathology of inflammatory nasal polyps were 19 patients or 76%, while patients of nasal eosinophil polyps were six patients or 24%. Additionally, patients with comorbidity in nasal polyps of allergic rhinitis medical history were 11 patients or 44%. Also, bilateral nasal polyps were mostly experienced by patients, reaching 14 patients or 56%. Conclusion: This study reveals nasal polyps in women aged 51-60 years with clinical symptoms of nasal obstruction with the results of a histopathological examination of the inflammation type at bilateral polyps.

Nasal polyps: medical or surgical management?

Clinical <html_ent glyph="@amp;" ascii="&"/> Experimental Allergy, 1996

Sinonasal polyposis represents a chronic inflammatory condition of unknown etiology. It is often associated with systemic diseases and is characterized by nasal obstruction, reduction in sense of smell, infection, and impaired quality of life. Endoscopy has enhanced the diagnosis and management of nasal polyps. The initial approach is medical management. Medical therapy consists of administration of intranasal steroids or a short course of systemic steroids. Other medical treatments considered are use of antibiotics, leukotriene modifiers, and acetylsalicylic acid avoidance. Surgical removal is performed for nonresponders to medical management. The purpose of surgery is to restore the nasal physiology by making the nose free from nasal polyps and allowing drainage of infected sinuses. With a computer-assisted navigation system and power instrumentation, surgical removal of polyps can be done more easily and accurately with fewer complications than previously. Medical therapy after surgery is essential for preventing recurrence.

Nasal Polyps and Rhinosinusitis

Allergy and Allergic Diseases, 2008

Inflammation of the paranasal sinuses, or sinusitis, is one of the three most common health care complaints 1 and accounts for high socio-economic costs and lost school or working days both in children and adults. The high prevalence recently led to an increasing interest in the pathophysiology of different forms of sinusitis as the basis for better treatment modalities.

The effectiveness of steroid treatment in nasal polyposis

Auris Nasus Larynx, 2003

Objective: The objectives of the management of nasal polyposis are to eliminate or reduce the size of polyps, reestablish nasal breathing, reduce symptoms of rhinitis, restore the sense of smell, and prevent the recurrence of nasal polyps. Local or systemic steroids have been used in the treatment of nasal polyps, but efficacy of combined (local and systemic) steroids in nasal polyposis has been little investigated. The aim of this study was to evaluate the influence of combined steroid therapy on the symptoms and extent of the disease in patients with nasal polyposis. Methods: Seventeen patients with nasal polyps were treated with combined steroids. Before and after the therapy, polyp size, nasal symptoms, sense of smell, and headache or facial pain were assessed by an established scoring system. Results: After the therapy, symptom scores of all the patients improved. Of the patients, 12% showed a polyp-free nasal cavity, 76% a clear involution of polyps, and 12% no response to the therapy. There were statistically significant differences (P B/0.001) for symptom scores and polyp size. Medical ablation of polyps using steroids was not achieved in 88% patients. Conclusion: Steroids can reduce polyp sizes and improve the symptoms, but are inadequate to eradicate the polyps. Surgery still plays a major part in the treatment of the nasal polyposis, but steroids can delay the necessity for surgical intervention. #

European position paper on rhinosinusitis and nasal polyps 2007

Rhinology. Supplement, 2007

Rhinosinusitis is a significant and increasing health problem which results in a large financial burden on society. This evidence based position paper describes what is known about rhinosinusitis and nasal polyps, offers evidence based recommendations on diagnosis and treatment, and considers how we can make progress with research in this area. Rhinitis and sinusitis usually coexist and are concurrent in most individuals; thus, the correct terminology is now rhinosinusitis. Rhinosinusitis (including nasal polyps) is defined as inflammation of the nose and the paranasal sinuses characterised by two or more symptoms, one of which should be either nasal blockage/obstruction/congestion or nasal discharge (anterior/posterior nasal drip), +/- facial pain/pressure, +/- reduction or loss of smell; and either endoscopic signs of polyps and/or mucopurulent discharge primarily from middle meatus and/or; oedema/mucosal obstruction primarily in middle meatus, and/or CT changes showing mucosal ch...

Chronic Rhinosinusitis’s with Nasal Polyps

Journal of Pharmaceutical Research International, 2021

Chronic Rhinosinusitis is a chronic disease that negatively affects the quality of life. When associated with nasal polyps, there is worsening of the condition, and it becomes harder to treat due to the high rates of recurrence and the increased morbidity rates. Though having a set treatment method, the condition still has unknown etiology and pathophysiology, which makes it extremely hard to diagnose and evaluate. Due to these unknown factors, treatment is still not as precise and effective; we still rely on systemic drugs like corticosteroids which most often do not resolve the disease, and we then present surgical options, though effective still do not pose as an effective cure, which may be a factor in the high rate of recurrences. However, there have been giant leaps in the specialized research of this particular topic, leading to classification through biomarkers allowing us to study and consolidate data on the disease pathology and all of the different options causing recurre...

Nasal polyp (I) and its homoeopathic management

International Journal of Homoeopathic Sciences, 2022

Nasal polypi are oedematous masses of nasalor sinus mucosa. They are benign in nature. It is a surgical disease but can be treated with homoeopathic medicines. It is necessary to trace the case in early stage to manage with homoeopathic medicines. Along with understanding of the disease and knowledge of homoeopathic medicine, nasal polypi can be prevented effectively from recurrence even in case of surgical histories [1] .