A Prospective Observational Study of Comparison of Lipid Profile with Liver Function Tests in Dengue Fever (original) (raw)
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Comparison of Significance of Lipid Profile with Liver Function Tests in Dengue Fever
Journal of Evolution of Medical and Dental Sciences, 2019
BACKGROUND Dengue is the most prevalent mosquito borne viral infection with rapidly changing epidemiology over the last few years. Lipoproteins play a pathophysiological role in the hosts immune response to severe infection. The need to know the lipoprotein status in dengue fever, find its correlation with severity, liver function tests, and clinical outcome are the objectives of this study. METHODS This prospective observational study was taken up involving 50 adults diagnosed with dengue fever between December 2013 to December 2014 in Mysore Medical College. Patients were classified based on severity of dengue fever (DF), dengue haemorrhagic fever (DHF), dengue shock syndrome (DSS). Fasting lipid profile, liver function test (LFT), complete blood count were estimated on day 1 and day 5 of admission. RESULTS The study population comprised of 50 dengue sero positive cases. The total cholesterol was greatly reduced and LFT alterations were seen highest in DSS group. During admission, serum cholesterol and liver enzymes showed statistically significant difference in their mean concentrations in the three groups of dengue infection. The spearman correlation analysis shows that AST and total cholesterol had negative correlation (r=-0.782; p <0.01), whereas ALT and cholesterol also showed similar correlation (r=-0.738; p< 0.01). CONCLUSIONS Total cholesterol, HDL and LDL of dengue fever cases were significantly reduced at admission in comparison to the second estimation on day 5. Mean cholesterol, triglyceride and LDL levels showed statistically significant (p value <0.05) changes with severity of dengue. LFT was correlated with the severity of dengue fever. These abnormal values may serve as indicators for recognizing patients at increased risk for DHF and DSS, thus serving as prognostic markers of the dengue infected individuals.
The British journal of nutrition, 2018
PUFA might modulate inflammatory responses involved in the development of severe dengue. We aimed to examine whether serum PUFA concentrations in patients diagnosed with dengue fever (DF) were related to the risk of progression to dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS). A secondary aim was to assess correlations between fatty acids (FA) and inflammatory biomarkers in patients with DF. We conducted a prospective case-control study nested within a cohort of patients who were diagnosed with DF and followed during the acute episode. We compared the distribution of individual FA (% of total FA) at onset of fever between 109 cases who progressed to DHF/DSS and 235 DF non-progressing controls using unconditional logistic regression. We estimated correlations between baseline FA and cytokine concentrations and compared FA concentrations between the acute episode and >1 year post-convalescence in a subgroup. DHA was positively related to progression to DHF/DSS (multivar...
The Association of Lipoprotein Changes and the Development of Plasma Leakage in Dengue Infection
eJournal Kedokteran Indonesia
There's interrelationship between infection and lipoprotein. This is a cohort prospective study which conducted November 2010-February 2011. This study aimed to assess the changes of HDL-C, LDL-C, total cholesterol (TC), triglyceride (TG), in acute and critical phase of dengue infection and its association with plasma leakage. Subjects who had fever 48 hours or less and Dengue NS1 antigen test positive were admitted to Cipto Mangunkusumo Hospital Jakarta. We examined clinical and CBC daily; level of albumin,
Biochemical alterations as markers of dengue hemorrhagic fever
The American journal of tropical medicine and hygiene, 2008
We evaluated biochemical alterations as predictors of dengue hemorrhagic fever (DHF). Patients with confirmed infection with dengue virus were prospectively evaluated for the first seven days of disease to determine their final clinical outcome. Serum samples taken 48-96 hours after onset of fever were used for biochemical tests. Of 199 patients, 30 developed DHF. Cases of DHF had higher levels of lactate dehydrogenase (LDH), creatine kinase (CK), and aspartate aminotransferase, and lower levels of albumin, total cholesterol, and triglycerides. Multivariate analysis showed that early alterations of CK (hazard ratio [HR] = 6.98, 95% confidence interval [CI] = 2.34-20.85, P = 0.001), LDH (HR = 3.19, 95% CI = 1.01-10.12, P < 0.05), and albumin (HR = 2.54, 95% CI = 1.09-5.92, P = 0.03) were associated with DHF. Triglyceride levels > 160 mg/dL were negatively associated with developing DHF (HR = 0.07, 95% CI = 0.01-0.59, P = 0.01). Early alterations of biochemical markers can predi...
CORRELATING BIOCHEMICAL AND HEMATOLOGICAL PARAMETERS IN PATIENTS WITH DENGUE
Asian Journal of Pharmaceutical and Clinical Research Journal, 2022
Objectives: The objectives of this study were to ascertain the correlation of the various biochemical and hematological parameters to dengue positive status. Methods: Based on review of literature, we calculated the correlation of biochemical and hematological parameters of liver profile in dengue positive and dengue negative patients in a convenience sampling of 140 dengue negative and 49 dengue positive cases. Results: Total bilirubin (TBI), total plasma protein, globulin, and alkaline phosphatase showed inverse correlation to dengue positive status, while albumin/globulin ratio elicited direct correlation. (p˂0.05) Other parameters, namely, random blood sugar, direct bilirubin, indirect bilirubin, albumin, SGPT, and SGOT showed no clear cut correlation with dengue positive or negative status (p>0.05). Conclusions: TBI, total plasma protein, globulin and alkaline phosphatase, and albumin/globulin ratio should be ascertained in a large equal groupsize randomized study to establish their authenticity as prognosticators of the disease.
BMC Pediatrics
Background: Series of biochemical and haematological changes occur during the course of dengue infection, which vary depending on the clinical disease. The patterns of change are not well documented and identifying these patterns in children with dengue infection would help to anticipate the progression to different clinical stages thus enabling effective management. Methods: A prospective follow up study was conducted during the period of July 2013-April 2014 at Professorial Pediatric unit, Lady Ridgeway Hospital for Children, Colombo, Sri Lanka. Children (5-12 years) admitted within the first 84 h of fever, with a clinical diagnosis of dengue infection were recruited. Children who became positive for dengue IgM were included in the final analysis. Blood was collected on admission for complete blood count, Alanine aminotransferase, Aspartate aminotransferase, albumin, cholesterol and corrected calcium. These tests were repeated at 12 hourly intervals during the hospital stay. Results: Data of 130-subjects were analyzed (Dengue fever /Dengue hemorrhagic fever: 100/30). There was a significant difference in the pattern of white cell counts, platelets and haematocrit in the two clinical groups. Both transaminase rose initially in both dengue fever and dengue hemorrhagic fever and a steep rise were seen between 8th and 9th days in hemorrhagic fever. Both albumin and cholesterol decreased significantly at the time of entering into the critical phase. According to Receiver operating characteristic curve analysis, albumin level crossing 37.5g/L (sensitivity 86.7%, specificity 77.8%) and a 0.38 mmol/L reduction in cholesterol level (sensitivity 77. 3%, specificity 71.9%) between day 3 and 4 were the best predictors of entering into critical phase. Calcium levels did not show any distinct pattern. Conclusions: There is a clear difference in the pattern of change of both hematological and biochemical parameters in dengue fever and dengue hemorrhagic fever. Reduction in albumin and cholesterol levels seen between the completion of day 3 and day 4 were highly valid predictors of entering into critical phase in dengue hemorrhagic fever.
Effect of Dengue on Haematological Profile and Liver Function
Journal of Evidence Based Medicine and Healthcare
BACKGROUND Dengue is considered to be the most common arboviral disease worldwide and one of the most important emerging viral tropical diseases which affects up to 100 million people across the tropical world. Dengue infection is associated with major changes in haematological profile of the patients. Even though the liver is not the major target organ, pathological findings such as hepatocellular necrosis and inflammatory cell infiltration have been identified in liver biopsy specimens of patients with Dengue and it is reflected by the derangement in liver enzymes. Our study aims at studying the haematological changes and alterations in liver functions in patients affected by dengue. METHODS A total of 820 serologically confirmed cases of dengue was included in the study during the period June 2016-December 2017. Demographic details, clinical details and Laboratory investigations such as total count, differential leukocyte count, platelet count, liver function tests were collected from medical records, entered and statistically analysed. RESULTS A total of 820 serologically confirmed cases of dengue were included in the study. 800 patients (97.4%) were classical DF case, 7 (1%) were DHF and 13 (1.6%) were DSS. Our study showed a of M:F ratio of 1:1.04. Dengue infection was associated with major haematologic changes such as leukopenia (56%), and thrombocytopenia (86%). In addition to the haematological changes, the disease is associated with significant alteration in liver function test such as elevation of SGPT and SGOT, hypoalbuminemia and elevation of serum bilirubin. CONCLUSIONS Our study shows that in addition to haematological abnormalities, dengue virus infection is associated with major derangements of liver function such elevated transaminase levels, hypoalbuminemia and hyperbilirubinemia. Leukopenia, thrombocytopenia, raised SGPT and SGOT necessitate further evaluation by testing for dengue in febrile patients in post rainy seasons so that early therapeutic measures can be initiated to reduce the morbidity and mortality.
Tropical Medicine and Infectious Disease, 2020
Although serum lipopolysaccharide (LPS) was shown to associate with development of severe dengue, the reasons for high LPS and its subsequent involvement in disease pathogenesis are not known. We assessed serum LPS, C-reactive protein (CRP), and procalcitonin in patients with acute dengue fever (DF = 129) and dengue haemorrhagic fever (DHF = 64) and correlated these observations with the presence of comorbid illnesses, and clinical disease severity. Serum LPS levels were significantly (p = 0.01) higher in patients with DHF, compared to those with DF. In total, 45 (70%) of those with DHF and 63 (49%) of those with DF had detectable LPS and therefore, the presence of LPS was significantly associated with DHF (p = 0.005, OR = 2.48, 95% CI: 1.29 to 4.64). Those with metabolic diseases, 22/29 (75.9%) and those with atopic diseases 17/22 (77.3%) were significantly more likely to have detectable LPS levels (p = 0.025, OR = 2.9, 95% CI-1.17 to 7.59 and p = 0.039, OR = 3.06, 95% CI-1.07 to 7...
MGM Journal of Medical Sciences, 2015
Background: Dengue fever with its severe manifestations, such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) has emerged as a major public health problem of international concern. Dengue, presenting as dengue fever (DF) or DHF or DSS, also has some effect on liver function. This study was conducted to find out the impact of dengue on liver function and correlation between clinical manifestation of dengue fever and degree of liver injury. Materials and methods: This prospective randomized study was done on 200 outpatient department/inpatient department (OPD/IPD) patients in age group of 12 to 60 years including both sexes who confirm to the predetermined inclusion and exclusion criteria. Investigation included measure ments of serum glutamic oxaloacetic transaminase (SGOT), serum glu tamic pyruvic transaminase (SGPT), prothrombin time/inter national normalized ratio (PT/INR) and creatinine. Degree of liver involve ment was classified in four groups. Results: Out of 200 cases, 181 (90.5%) were diagnosed as dengue fever, nine (4.5%) as DHF, five (2.5%) as DSS, five (2.5%) as hepatorenal involvement; 24 (12.0%) had grade 0 liver injury, 126 (63.0%) had grade 1 liver injury, 34 (17%) had grade 2 liver injury, 10 (5.0%) had grade 3 liver injury and six (3.0%) had grade 4 liver injury. Conclusion: Mild elevation of the liver enzymes is a common feature of dengue infection. There is high relation between the degree of liver damage and the appearance of the complications.