Drug Utilization Pattern during Pregnancy in a Government Maternity Hospital -A Prospective Study (original) (raw)
Related papers
Drug utilization pattern in pregnant women in a tertiary care hospital , Hyderabad , Telangana
2016
Pregnancy is associated with physiological changes in the pharmacokinetics and pharmacodynamics of the drugs. Also, use of drugs in pregnancy poses great risk to the mother and fetus. It therefore requires special care to prescribe drugs to pregnant women. The main objective of this study was to explore drug utilization in pregnant women attending a private sector tertiary healthcare institution. This was a cross-sectional case study in women attending outpatient clinic, Unit I, Department of Obstetrics and Gynecology, Malla Reddy Institute of Medical Sciences. The required information obtained from their prescriptions and 174 case notes was collected in a structured data collection sheets and the results were analysed using microsoft office. There were 80 (45.9%) primigravidae, 94 (54%) multigravidae and 69 (39.6%) women were in the second trimester of pregnancy. Most women (57.4%) were between 21−25 years of age. Average number of drugs prescribed per prescription was 2.4, encount...
Drug utilization pattern during pregnancy in North India
Indian Journal of Medical Sciences, 2006
BACKGROUND: Pregnancy is a special physiological condition, where drug treatment presents a special concern. AIMS: To evaluate the drug utilization pattern during pregnancy and to evaluate the effect of the educational and economic status on it.. DESIGN: The retrospective cross-sectional study. SETTING: The postgraduate Department of Pharmacology and Therapeutics of a medical college. and the antenatal clinic of the institution. MATERIALS AND METHODS: Medical students filled 405 questionnaires after interviewing pregnant women (243 primigravida and 152 multigravida). All the collected questionnaires were analysed for various study parameters. STATISTICAL ANALYSIS USED: Inter-group comparison was done using chi-square test. P value <0.05 was considered statistically significant. RESULTS: A total of 700, 1086 and 686 drugs, with an average of 1.73, 2.89 and 2.49 drugs per pregnant women, were used during first, second and third trimester of pregnancy, respectively. A majority of the drugs used, were from category-A, followed by category-B and category-D. However, category C and X drugs constituted 2.90 (20) and 5.71% (40) of drugs used during the third trimester and first trimester, respectively. Herbal/ homeopathic drugs constituted 6.42 (45), 3.68 (40) and 1.46% (10) of the drugs used in the first, second and third trimester of pregnancy, respectively (P=649). 33.33% (135) women believed that drug use during pregnancy is dangerous to both mother and child and 37.03% (150) believed that drugs are dangerous throughout pregnancy. 55.55% (225) females advocated the use of iron/folic acid during pregnancy. 24.69% (100) of women had knowledge about barrier contraceptives. Self-medication and homeopathic/ herbal drugs use was found more in graduates than in undergraduates; as well as, it was more in the higher socioeconomic group than the lower socioeconomic group. CONCLUSION: There is a need to educate and counsel women of child-bearing age, regarding the advantages and disadvantages of drug use during pregnancies, with special reference to alternative therapies and self-medication.
Prescription Pattern of Drugs in Pregnancy: A Review
International Research Journal of Pharmacy, 2015
Authors carried out a systematic review of peer-reviewed literature published from 2005-2014. We incorporated studies assessing individual-level exposures to medicines prescribed during pregnancy. We selected only those studies conducted in India and published in English. Published drug utilization studies reveal about 22% to 69.8% overall use of prescribed drugs during pregnancy excluding vitamins and minerals. On measuring antenatal drug use, the medications with positive evidence of risk (FDA category D) ranged from 4.8% to 24.25%. Iron, folic acid and vitamin supplements were most commonly prescribed drugs globally depending on the need of the patient and their benefit ratio. Overall drug use estimates are examined, use of drugs by therapeutic categories and by potential for fetal risk is considered while updating this review. Several studies consistently reported the usage of drugs with potential risks during pregnancy. Due to such extensive use, it is essential to develop standards for assessing and reporting antenatal exposures to refine any future research in this field. The prescribing practices of Indian physicians are similar to those in developed countries.
Innovative Publication, 2016
Background: The principal aim of drug utilization research is to facilitate the rational use of drugs in populations. Pregnancy is a special physiological condition. Careful consideration of the benefit to the mother and the risk to the foetus is required while prescribing drugs during pregnancy. Material and Methods: Present study was Prospective, non-interventional & observational study conducted among 711 antenatal women in Obstetrics & Gynaecology Dept. during October 2014 to September 2015. Result: Out of 711 antenatal women majority 328 (46.13%) were in the age group of 22-25 years. Majority 568 (79.89%) of antenatal women were having mild anaemia while 21 (2.95%) were having moderate anaemia and majority of antenatal women were suffering from nausea and vomiting (12.37%) followed by pre-eclampsia (5.90%) and fever (3.79%). Most commonly prescribed drug was ferrous sulphate in 545 encounter followed by calcium, and vitamin B-complex same encounter 543. Total prescribed drug were 2661, from this most commonly prescribed drug class was miscellaneous about 1628 (61.18 %) drugs. Most commonly prescribed Drug in 1 st trimester was folic acid 167 (97.6%) while in 2 nd and 3 rd trimester it was ferrous sulphate 269 (98.89%)and 265 (98.88%) respectively. Average number of drugs prescribed was 3.74. Majority 2395 (90%) of drugs prescribed by generic name. Most of the prescribed drugs were belongs to FDA category A (91.13%). Conclusion: Most commonly prescribed drugs for antenatal women were ferrous sulphate, calcium, and vitamin B-complex by oral route.
Assessment of Prenatal Drug Prescription Pattern at Mbabane Government Hospital
Background: Pregnancy is the time of profound physiological changes in a female's body. Maternal drug use during pregnancy may pose a teratogenicity risk to the fetus. However, the fact that drugs are needed to mitigate the complications during pregnancy cannot be avoided, therefore, this study is designed to assess prenatal drug prescription pattern at Mbabane Government Hospital.
BMC pregnancy and …, 2008
Background: The rationale for use of drugs during pregnancy requires a careful assessment as in addition to the mother, the health and life of her unborn child is also at stake. Information on the use of drugs during pregnancy is not available in Pakistan. The aim of this study was to evaluate the patterns of drug prescriptions to pregnant women in tertiary care hospitals of Pakistan. Methods: This was a cross-sectional study conducted at five tertiary care hospitals of Pakistan. Copies of outpatient medicinal prescriptions given to pregnant patients attending the antenatal clinics were collected. The drugs were classified according to the pharmacological class and their teratogenic potential. Results: All the pregnant women attending the antenatal clinics received a prescription containing at least one drug. A total of 3769 distinct prescriptions given to different women were collected. Majority of the women who received the prescriptions belonged to third trimester (55.4%) followed by second (33.6%) and first trimester (11.0%). On an average, each prescription contained 1.66 ± 0.14 drugs. The obstetricians at Civil Hospital, Karachi and Chandka Medical College Hospital, Larkana showed a tendency of prescribing lesser number of drugs compared to those in other hospitals. Antianemic drugs including iron preparations and vitamin and mineral supplements (79.4%) were the most frequently prescribed drugs followed by analgesics (6.2%) and anti-bacterials (2.2%). 739 women (19.6%) received prescriptions containing drugs other than vitamin or mineral supplements. Only 1275 (21.6%) of all the prescribed drugs (n = 6100) were outside this vitamin/mineral supplement class. Out of these 1275 drugs, 29 (2.3%) drugs were prescribed which are considered to be teratogenic. Misoprostol was the most frequently prescribed (n = 6) among the teratogenic drugs followed by carbimazole (n = 5) and methotrexate (n = 5). Twenty nine pregnant women (0.8% of all the women studied) were prescribed these teratogenic drugs. Conclusion: Less than one percent of the pregnant women attending tertiary care hospitals in Pakistan are prescribed teratogenic drugs. The prescribing practices of Pakistani physicians are similar to those in western countries.
2020
Objective: To carry out prescription analysis and assign risk category as per USFDA (United States Food and Drug Administration) to prescribed drug during pregnancy in a tertiary health care center at Raipur, Chhattisgarh.Method:This cross-sectional study was carried out over the period of 2 months in obstetric OPD (outpatient department) at tertiary health care center Raipur. Pregnant woman of any trimester was recruited from ANC (antenatal clinic) after obtaining informed written consent. Important information collected was demography, gravida, parity, trimester of pregnancy, reason for visit to clinic, history of any chronic illness, names of drugs prescribed with their doses and frequency of administration. Prescription analysis was carried out and USFDA risk category had been assigned to each of the drug.Results:Total 340 drugs were prescribed for 75 patients.And 51.43% pregnant women were from 3rd trimester of pregnancy. Most of pregnant women(92.86%) reported to OPD for regul...
Asian Journal of Pharmaceutical and Clinical Research Journal, 2022
Objective: The aim of the study was to study and evaluate the pattern of drug use in pregnant women attending the antenatal clinic of obstetrics and gynaecology department at a tertiary care hospital. Methods: A prospective observational study was conducted at the Department of Gynecology and Obstetrics in M.G.M. Medical College and Hospital, Kishanganj, Bihar. The study included 368 pregnant women who consented and provided written informed consent for participation in this study during the study period from January 2020 to November 2021. Results: Time for seeking the first antenatal check-up was majorly in 1st trimester (48.10%), followed by 35.60% in the 2nd and 16.30% in the 3rd trimester. A total of 3054 drugs were prescribed in all three trimesters from all organ systems. The majority belonged to blood and bone-forming agents, followed by antimicrobials and gastrointestinal drugs. Analyzing the prescribing trend grossly depicts that the drug prescribing showed a gradual increase from 18 to 2nd trimester, followed by a slow drop in 3rd trimester. During the entire study period, there were 177 prescriptions for 1st trimester, 306 prescriptions for 2nd trimester, and 366 prescriptions for 3rd trimester. Conclusion: Our study site revealed a greater tendency to prescribe by generic name rather than by brand name in our hospital, which is a good sign as it reduces the economic burden on the patients. In other previous studies, it was less. Prescribing percentage of antibiotics in all trimesters was on the high rise, while the percentage of encounters with injection was within acceptable ranges. The majority of prescribing corroborated with national drug policy and was in concurrence with the national drug formulary and NLEM 2015, which reflects the essence of rational prescribing of pregnancy drugs in our set-up.
Morbidity Pattern and Drug Prescribing Study in Pregnant Women of Rural Part of Charotar Region
Indian Journal of Pharmacy Practice, 2020
Background: Pregnancy is a normal physiological condition where drug treatment presents a special concern because certain drugs that harm to the fetus due to the potential teratogenic effects of drugs. Therefore, the present study was planned to carry out with the objective to evaluate the drug prescribing pattern, morbidity and categories of safe drug prescribing among all the pregnant women. Materials and Methods: A cross-sectional observational study was carried out in 400 pregnant women who attended inpatient and outpatient department at CHARUSAT Hospital during 8 months of study. Demographic details, prescribed drugs, medical history and diagnosis were recorded in CRF. The prescription pattern was assessed and drugs were classified based on USFDA Risk Classification. Results: In present study, iron (82.65%), folic acid (53.62%), calcium (58.51%) and vitamins (82.84%) were found the most frequently prescribed drugs during pregnancy. Anti-emetics, PPIs and H2 blockers, Antibiotic...
Evaluation of Usage of Drugs in Pregnancy at Private Hospitals
Indian Journal of Pharmacy Practice, 2021
Background: Pregnancy represents a special physiological state during which the use of the drug is inevitable due to the risk of teratogenicity with drugs. The evaluation of prescribing drugs in pregnancy is required due to a lack of knowledge about the harmful effects of these drugs in pregnant women and fetuses. Aim: To evaluate prescribing pattern of drugs and the FDA drug risk category in pregnant women at private hospitals. Materials and Methods: The observational prospective and multicenter study were conducted in 386 pregnant women for 6 months. Each prescription was analyzed for demographic variables, medical illness, antimicrobials, risk categories of drugs prescribed, dosage forms, and WHO prescribing indicators. Results: A total of 2507 drugs were reported in the 637 prescriptions of 386 patients. A large proportion of women had anemia during pregnancy (42.9%). Majority of prescriptions prescribed oral dosage forms of drugs (81.53%) and injections (15.59%). The majority of drugs used in this study were from Category A which included anti-anemic, thyroid therapy drugs, vitamins, and minerals, followed by category C which included calcium supplements, muscle relaxants, and antihypertensive medications. No drugs were prescribed from category X. Conclusion: Iron, Calcium, and Folic acid along with Vitamins and Minerals were the most frequently prescribed drugs. In general, the drug use pattern is rational with few exceptions. The majority of drugs were used from category A followed by Category C. Drugs prescribed by their Brand name were higher than prescribed by their Generic name.