Comparison of Sedation and Analgesia Produced By Dexmedetomidine and Butorphanol in Critically Ill Patients on Mechanical Ventilation: A Prospective Observational Study (original) (raw)
2019, IOSR Journals
BACKGROUND: Sedation in the intensive care unit for critically ill patients on mechanical ventilation is a complex clinical problem, and the current therapeutic approaches have potential side effects. This study aimed at comparing inj. Dexmedetomidine with inj.Butorphanol as sedative and analgesia. METHODS: 60 Patients of both sexes in the age group of 18-60 yrs requiring mechanical ventilation are included in the study. Once the patient on mechanical ventilation, the infusion of the specified drug was started using a syringe pump. Dexmedetomidine started at the rate of 1mcg/kg/hr loading dose over 15 minutes followed by 0.25 mcg/kg/hr, and Butorphanol was started at the rate of 5mcg/kg/hr depending upon the parameters of assessment and requirement of the patient. The infusion continued for 24hrs. Vital parameters, Ramsay Sedation score, Behavioural pain score were compared. RESULTS: The patients receiving Dexmedetomidine infusion were hemodynamically more stable and were easily arousable when compared to patients receiving Butorphanol infusion CONCLUSION: Dexmedetomidine is a suitable alternative to the commonly used sedatives in ICU, but its high cost may limit its use in the initial phase.
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