Comparison of the effect of cronolone sponges and PMSG or cloprostenol on estrous induction in Turkish Saanen goats (original) (raw)
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The objective of this study was to evaluate the duration of three progestagen treatments for estrous synchronization in lactating Turkish Saanen goats during the transitional period from anestrous. All does (n=60) were divided into three equal groups and the estrous period of the does was synchronized using intravaginal sponges (20 mg FGA) for either 11 days (Group 1), 9 days (Group 2) or 6 days (Group 3). In addition, 24h before sponge removal (on the 10 th day, 8 th day and 5 th day, respectively) each doe was injected with 0.075 mg cloprostenol (PGF 2a) and 500 IU eCG. Cervical artificial inseminations (AI) with frozen-thawed semen were performed at fixed intervals (36 and 48 h) following progestagen withdrawal. The total estrous response following the first withdrawal was 12 ± 6 h within 66 h. Time to onset and duration of the induced estrous, and pregnancy rates were recorded to be 30.0%, 100%, 23.9±0.7 h, 29.4±1.3 h, and 28.3%, respectively. There were significant differences between Group 1 and the other groups, in terms of the onset of induced estrus (P<0.05) and estrous response for the first 12 ± 6 h (P<0.05) and between Group 2 and Groups 1 and 3 in terms of the duration of induced estrous (P<0.05). Each of the three protocols was effective in inducting and synchronizing estrus in lactating Turkish Saanen goats.
The purpose of the experiment was to test the hypothesis that a variable and/or insufficient level of progestagen at the end of a treatment to synchronize estrus in goats could explain variability in the onset of estrus. The experiment was performed during the anestrous season on 2 herds, one of Alpine (n = 49) the other of Saanen (n = 53) dairy goats. The animals were allocated to 1 of 3 treatments: Group 1 received a vaginal sponge impregnated with 45 mg of fluorogestone acetate (FGA) on Day 0; Group 2 received a sponge on Day 0 plus a second sponge on Day 7; Group 3 received a sponge on Day 0 plus a second sponge on Day 9. The sponges were withdrawn on Day 11. All goats received 400 or 500 IU eCG and 50 μg PGF2α analog 48 h prior to sponge removal. They were inseminated with frozen-thawed semen 24 h after the onset of estrus. Among treatment groups no difference (P > 0.05) was observed for the following parameters: percentage of goats in estrus, percentage of goats ovulating, mean time and variability of onset of estrus. The fertility of Alpine goats in Group 3 was significantly decreased (P < 0.05). No effect on prolificacy was noticed. These observations show that to increase progestagen level at the end of treatment did not improve estrus synchronization. They provide further evidence that treatments with too high progestagen amounts can decrease fertility.
Revista científica de veterinaria
Estrus induced with progesterone or progestagens have low fertility compared to natural estrus. However, post-mating progesterone administration has been reported by increases embryo development and pregnancy rate; therefore the aim of this study was to evaluate the effect of post-mating progestagen administration on pregnancy rate after medroxyprogesterone acetate (MAP) induced estrus in crossbred goats. Estrus induction was started at 31.3 ± 1.7 days post-partum with intravaginal sponges impregnated with 60 mg of MAP during 14 days and at time of sponge removal were applied 500 IU of eCG intramuscular. Estrus was detected every 6 hours from 24 hours onwards after sponge withdrawal. Goats were naturally mated with two entry bucks. Five days post-mating, mated goats were randomly assorted into two groups, control group (n=18), without any treatment, and MAP group (n=18), receiving a sponge with 60 mg of MAP for fourteen days. Ultrasonographyc diagnosis of pregnancy was performed at day 50 post-mating. MAP treatment, did not affect the pregnancy rate, with 44.4% (8/18) in MAP group, while in control group was 55.5% (10/18), P>0.05. In conclusion, MAP treatment with a sponge impregnated with 60 mg of MAP between days 5 and 19 post-mating did not affect the pregnancy rate after progestagen induced estrus during the early post-partum period in crossbred tropical goats.
2012
The objective of the present study was to evaluate the effect of a progestagen treatment alone or in combination with equine chorionic gonadotrophin (eCG) on estrus response in Sahel (SH) goats. One hundred (n=100) SH does were treated with 30 mg fluorogestone acetate (FGA) sponge for 14 days. At the end progestagen treatment, does that retained the intravaginal pessary were allocated into two groups; A: FGA & eCG (n=42) and B: FGA (n=41). Does in group A received additional 200 IU eCG i.m. concurrent with sponge removal. Estrus was detected twice daily (at 07.00 – 10.00 and 15.00 – 18.00 h) using sexually active bucks for 5 days after pessary removal. Estrus response was different (p
ESTRUS SYNCHRONIZATION WITH MEDROXYPROGESTERONE ACETATE IMPREGNATED SPONGES IN GOATS (CAPRA HIRCUS
An experiment was performed to synchronize estrus in goats by locally prepared progesteroneimpregnated sponges and to determine the time of onset and duration of estrus alongwith subsequent fertility rate. The study was conducted from May to December, 2007 at NIAB (Nuclear Institute for Agriculture and Biology), Faisalabad. Polyurethane sponges were prepared with medroxyprogesterone acetate (MAP: 60 mg) and inserted intra-vaginally in a lot of 8 female postpartum goats (Beetal x Dwarf). Two goats were kept as control and were treated with sponges without MAP. Sponges were removed on 17 th day of insertion and goats were examined for the signs of estrus at 6 h intervals. A buck was introduced in the herd for breeding, one day after removal of sponges. Estrus was further confirmed by determining serum estradiol levels using radioimmunoassay (RIA). All the experimental goats exhibited estrus within 21-100 h of removal of sponges, whereas one control animal also showed estrus. The average time from sponge withdrawal to the onset of estrus was 65.4 ± 24.0 h and duration of estrus was 29.8 ± 6.7 hours in experimental group. The control animal showed estrus after 22.0 h of sponge removal with estrus duration of 36 h. Estradiol concentrations in experimental lot were in the range of 2.2-15.0 pg/ml during estrus. Animals were observed for reversal towards estrus after 21 days. Only one experimental animal exhibited 2 nd estrus. Pregnancy was confirmed by ultrasound after 60 days of sponge removal. The gestation period of 150.4 ± 3.4 days, a litter size of 1.3 ± 0.5 and a fertility rate of 87.5% were observed in the experimental lot. The control doe produced a male kid after 150.0 days of gestation. It is evident from this experiment that estrus can be synchronized in goats (Beetal x Dwarf) by locally prepared progesterone sponges with good fertility rate.
Estrus induced with progesterone or progestagens have low fertility compared to natural estrus. However, post-mating progesterone administration has been reported by increases embryo development and pregnancy rate; therefore the aim of this study was to evaluate the effect of post-mating progestagen administration on pregnancy rate after medroxyprogesterone acetate (MAP) induced estrus in crossbred goats. Estrus induction was started at 31.3 ± 1.7 days post-partum with intravaginal sponges impregnated with 60 mg of MAP during 14 days and at time of sponge removal were applied 500 IU of eCG intramuscular. Estrus was detected every 6 hours from 24 hours onwards after sponge withdrawal. Goats were naturally mated with two entry bucks. Five days post-mating, mated goats were randomly assorted into two groups, control group (n=18), without any treatment, and MAP group (n=18), receiving a sponge with 60 mg of MAP for fourteen days. Ultrasonographyc diagnosis of pregnancy was performed at day 50 post-mating. MAP treatment, did not affect the pregnancy rate, with 44.4% (8/18) in MAP group, while in control group was 55.5% (10/18), P>0.05. In conclusion, MAP treatment with a sponge impregnated with 60 mg of MAP between days 5 and 19 post-mating did not affect the pregnancy rate after progestagen induced estrus during the early post-partum period in crossbred tropical goats.
Theriogenology, 2007
This study assesses the effectiveness of a method designed to induce and synchronize ovulation in goats during the nonbreeding season, allowing for systematic timed artificial insemination (AI), without the need for prior estrus detection. This method (IMA.PRO2 1 ) induces ovulation through the ''male effect'' and a single 25 mg dose of progesterone given at the time of buck exposure, and early lysis of the induced corpus luteum by the administration of 75 mg of cloprostenol 9 days later. The method was tested in three separate experiments. In experiment 1, estrus was detected in 87.5% of the treated goats 37.0 AE 1.4 h after cloprostenol administration, with the preovulatory LH surge occurring 40.5 AE 1.6 h after the cloprostenol injection. In experiment 2, data from 503 does revealed no significant differences in fertility rates between two groups inseminated 48 h (65.5 AE 4.0%) or 52 h (63 AE 3.0%) after receiving cloprostenol. In experiment 3, 2184 does, comprising 37 replicate groups on 12 farms, were randomly assigned to two trial subgroups. Does in the first subgroup were treated with the IMA.PRO2 1 method and goats from the second group were given intravaginal progestagens for 11 days, plus 350 IU of eCG and 75 mg of cloprostenol on Day 9 of this treatment. Goats from both subgroups were cervically inseminated at the same time, 50 h after cloprostenol administration in the first group and 46 h after sponge removal in the second. The pregnancy rate achieved with the new method was 64.6%, significantly higher than the yield observed for the use of progestagens plus eCG (46.8%, P < 0.01). The simple method proposed as an alternative to the use of progestagen-eCG treatment provides good pregnancy rates to AI undertaken at a fixed time point, and reduces the amount of hormone needed to synchronize estrus in the animals. #
2009
ABSTRACT To induce oestrus out of the season in breeding goats maintained at a commercial farm were randomly treated with three regimes of progestagen treatments-i) 300 mg prepared progesterone (P4) sponges (n= 150) for 18 days, ii) 300 mg prepared progesterone (P4) sponges for 18 days followed by 300 IU eCG on the day of implant withdrawl (n= 220) iii) P4 in oil 25 mg given daily i/m for 10 days (n= 130) and iv) untreated control (n= 50).
Small Ruminant Research, 1996
The efficiency of medroxyprogesterone acetate (MAP) and fluorogestone acetate (FGA) sponges for synchronizing oestrus in lactating Saanen goats was investigated during the transition from non-breeding to natural breeding season. Does were treated for 11 days with 60 mg MAP (n=19) or 40 mg FGA (n=24) sponges. All does received intramuscular injections of 750 IU pregnant mare serum gonadotrophin (PMSG) and 125 µg cloprostenol (PGF 2 α) 48 h prior to sponge removal. Cervical artificial insemination (AI) with fresh diluted semen was performed at a fixed time (36 and 48 h) followed progestagen withdrawal. The two progestagen treatments showed no significant difference in oestrous response (100% both for MAP and FGA groups), time to the onset (15.8±09 and 15.0±06 h for the MAP and FGA groups, respectively), duration (30.5±1.9 and 34.0±1.4 h for MAP and FGA, respectively) and cessation (42.32±1.6 and 43.25±1.3 h for MAP and FGA, respectively) of the induced oestrus period. No significant difference was observed with respect to pregnancy rates determined at the 53 rd day after AI (52.6 and 50.0% for MAP and FGA, respectively). These dates indicate that the use of MAP and FGA intravaginal progestagen treatments are equally efficient in synchronizing oestrus in lactating goats during the transition from the non-breeding to the natural breeding season.