Brain Oxidative Stress and Selective Behaviour of Aluminium In Specific Areas of Rat Brain: Potential Effects In a 6-OHDA-Induced Model of Parkinson's Disease (original) (raw)

The study investigates the effects of aluminium on oxidative stress and selective behavior in specific areas of rat brains, particularly in the context of a 6-OHDA-induced model of Parkinson's disease. It highlights the mechanisms by which aluminium enters the brain and its potential neurotoxic effects, including lipid peroxidation and alterations in dopamine receptor expression. Experimental findings suggest significant changes in antioxidant enzyme activity and dopaminergic terminal density after aluminium exposure and 6-OHDA lesioning, indicating that aluminium may exacerbate neurodegeneration in Parkinson's disease models.