Facile synthesis of Carboxy methyl chitosan coated Iron Oxide Nanoparticles and their anti microbial activity (original) (raw)
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International Research Journal of Pure and Applied Chemistry, 2016
Aims: Synthesize and characterize a bio-polymer coated iron oxide nanoparticle, which has the potency to be used as an appropriate biomaterial for biomedical purpose. Magnetic iron oxide nanoparticles (MNPs) with biological coating exhibits many properties that can be exploited in a variety of biomedical applications. Place and Duration of Study: The study was performed at Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh from August 2013 to August 2014. Methodology: This research work describes the in-situ synthesis of chitosan-coated magnetic nanoparticles (CS MNPs) by co precipitation method where trisodium phosphate is added as ionic Original Research Article
The prominent research area in nanomedicine is drug delivery and targeting systems based on nanomaterials. An ideal drug delivery system should intelligently find the diseased tissue, accumulate drug carrying agents in this location and controllably release therapeutic molecules to this site. Among the efficient drug delivery systems, chitosan, a natural, biodegradable, biocompatible, bioadhesive polymer, is gaining attention in the pharmaceutical field for a wide range of drug delivery. Chitosan acts as a penetration enhancer by opening the tight epithelial junctions. Magnetic nanoparticles provide a magnetic targeting of the drugs to the diseased tissue. In this study, in situ synthesis method was used for the preparation of chitosan coated magnetic nanoparticles (CS MNPs), involving the co-precipitation of iron salts in the prescence of chitosan and tripolyphosphate. The CS MNPs synthesized through this method are monodispersed and their surface is uniformly coated with low molec...
Biological Properties of the Aggregated Form of Chitosan Magnetic Nanoparticle
In Vivo, 2020
Background/Aim: Chitosan-coated iron oxide nanoparticles (Chi-NP) have gained attention because of their biocompatibility, biodegradability, low toxicity and targetability under magnetic field. In this study, we investigated various biological properties of Chi-NP. Materials and Methods: Chi-NP was prepared by mixing magnetic NP with chitosan FL-80. Particle size was determined by scanning and transmission electron microscopes, cell viability by MTT assay, cell cycle distribution by cell sorter, synergism with anticancer drugs by combination index, PGE 2 production in human gingival fibroblast was assayed by ELISA. Results: The synthetic process of Chi-NP from FL-80 and magnetic NP increased the affinity to cells, up to the level attained by nanofibers. Upon contact with the culture medium, Chi-NP instantly formed aggregates and interfered with intracellular uptake. Aggregated Chi-NP did not show cytotoxicity, synergism with anticancer drugs, induce apoptosis (accumulation of subG1 cell population), protect the cells from X-ray-induced damage, nor affected both basal and IL-1β-induced PGE 2 production. Conclusion: Chi-NP is biologically inert and shows high affinity to cells, further confirming its superiority as a scaffold for drug delivery.
Synthesis and characterization of chitosan-magnetic iron nanoparticles
Kurdistan University of Medical Sciences, 2019
Absorption is a common technology used for water and wastewater treatment since it is often fast and efficient, while costly at the same time. Therefore, the development of low-cost and efficient adsorbents has led to the rapid growth of research interest in this regard. Chitosan is a natural polyaminosaccharide with effective adsorption properties, which is applied to remove various pollutants. However, it has low efficiency in the adsorption of some pollutants, and its separation from aqueous solutions is difficult as well. Therefore, modification of chitosan has been recommended to address this issue. The present study aimed to synthesize nanosized chitosan-magnetic iron particles and determine their properties. Magnetic iron nanoparticles were fabricated using the chemical precipitation method, and magnetic chitosan was prepared. Several methods were applied to assess the properties of the synthesized adsorbent, including scanning electron microscopy, X-ray diffraction, atomic force microscopy, Fourier-transform infrared spectroscopy, dynamic light scattering, and zeta potential. Chitosan-magnetic iron nanoparticles had higher surface roughness and irregular pores, and the magnetic iron nanoparticles were successfully embedded in chitosan. Due to the surface charge of the chitosan-magnetic iron nanoparticles, it could be used as an effective adsorbent for the removal of contaminants with negative charge and their complete separation from aqueous solutions using magnets.
Synthesis and characterization of chitosan-coated iron oxide nanoparticles
International Conference on Advanced Nanomaterials & Emerging Engineering Technologies, 2013
Silica nanoparticles (SNPs) with hydrogel capsule layer was easily prepared via radical polymerization of co-monomers N-isopropylacrylamide and acrylic acid in 96:4 and 91:9 wt% on the olefin terminated surface of SNPs. The hydrogel-encapsulated SNPs (SNPs@Hyd) have carboxylic acid groups, which can bind alternatively chitosan/alginate/chitosan chains to enhance the structural integrity of hydrogel composites. Chitosan-coated SNPs@Hyd exhibited prolonged releasing times of absorbed ibuprofens from hydrogel capsules entangled by alternative chitosan/alginate/chitosan chains. In particular, double chitosan-coated SNPs@Hyd (SNPs@Hyd@Chi@Algi@Chi) absorbed larger amount of ibuprofen than that of single chitosan-coated SNPs@Hyd (SNPs@Hyd@Chi), demonstrating a chemical strategy for preparing an efficient drug delivery system.
2012
Iron oxide nanoparticles (IONPs) were synthesized by coprecipitation of iron salts in alkali media followed by coating with glycol chitosan (GC-coated IONPs). Both bare and GC-coated IONPs were subsequently characterized and evaluated for their antibacterial activity. Comparison of Fourier transform infrared spectra and thermogravimetric data of bare and GC-coated IONPs confirmed the presence of GC coating on IONPs. Magnetization curves showed that both bare and GC-coated IONPs are superparamagnetic and have saturation magnetizations of 70.3 and 59.8 emu g−1, respectively. The IONP size was measured as ∼8–9 nm by transmission electron microscopy, and their crystal structure was assigned to magnetite from x-ray diffraction patterns. Both bare and GC-coated IONPs inhibited the growths of Escherichia coli ATCC 8739 and Salmonella enteritidis SE 01 bacteria better than the antibiotics linezolid and cefaclor, as evaluated by the agar dilution assay. GC-coated IONPs showed higher potency ...
Systematic Reviews in Pharmacy, 2020
During past years, researchers have focused on developing a technique that can be applied in biomedical field. Ongoing research efforts focused on iron oxide nanoparticles (IONPs) as one of those developed techniques. They have been widely used because of their unique properties. They are biocompatible, biodegradable with unique non-toxic magnetic properties. They can be synthesized with reliable surface modification. Thanks to these peculiar characteristics, IONPs appear as the starting point for the development of new therapeutic strategies in microbiology and oncology. Hence, the latest published works on newly developed surface modified IONPs are described, tackling the main benefits and drawbacks of the method of development, with particular emphasis on the possible applications in clinical practice as anticancer or antimicrobial agents. Looking forward, more progression in synthesis technologies of IONPs must continue to be optimized and developed to give rise to a new golden ...
Antioxidant efficacy of chitosan/graphene functionalized superparamagnetic iron oxide nanoparticles
Journal of Materials Science: Materials in Medicine, 2018
The antioxidant potential of superparamagnetic iron oxide nanoparticles functionalized with chitosan and graphene were examined in the present work. Coprecipitation technique was followed for the synthesis of iron oxide nanoparticles. Graphene-iron oxide nanocomposites were synthesized by mechanical mixing followed by the heat treatment at moderate temperature. The chitosan coated iron oxide nanoparticles were prepared by dispersing nanoparticles in chitosan solution. The nanoparticles/nanocomposites were characterized using XRD, SEM, TEM and HAADF-STEM for phase structure, morphology and elemental analysis. The superparamagnetic behavior of nanoparticles/nanocomposites were confirmed by magnetic measurements using vibrating sample magnetometry. Antioxidant efficacy of these nanoparticles/nanocomposites were investigated in terms of free radical scavenging and reducing potential using an array of in vitro assay system. Ferric reducing antioxidant power (FRAP) and 2,2′-diphenyl-1-picrylhydrazyl (DPPH) were used for the antioxidant capacity. The investigation suggests that the graphene improves the antiradical response of iron oxide nanoparticles at higher concentration which is almost comparable to the ascorbic acid used as standard.
Development of Chitosan Functionalized Magnetic Nanoparticles with Bioactive Compounds
Nanomaterials
In this study, magnetic maghemite nanoparticles, which belong to the group of metal oxides, were functionalized with chitosan, a non-toxic, hydrophilic, biocompatible, biodegradable biopolymer with anti-bacterial effects. This was done using different synthesis methods, and a comparison of the properties of the synthesized chitosan functionalized maghemite nanoparticles was conducted. Characterization was performed using scanning electron microscopy (SEM) and vibrating sample magnetometry (VSM). Characterizations of size distribution were performed using dynamic light scattering (DLS) measurements and laser granulometry. A chitosan functionalization layer was confirmed using potentiometric titration on variously synthesized chitosan functionalized maghemite nanoparticles, which is important for further immobilization of bioactive compounds. Furthermore, after activation of chitosan functionalized maghemite nanoparticles with glutaraldehyde (GA) or pentaethylenehexamine (PEHA), immob...
Advances in Natural Sciences: Nanoscience and Nanotechnology, 2016
In this work anti-cancer drug curcumin-loaded superparamagnetic iron oxide (Fe 3 O 4) nanoparticles was modified by chitosan (CS). The magnetic iron oxide nanoparticles were synthesized by using reverse micro-emulsion (water-in-oil) method. The magnetic nanoparticles without loaded drug and drug-loaded magnetic nanoparticles were characterized by XRD, FTIR, TG-DTA, SEM, TEM, and VSM techniques. These nanoparticles have almost spherical shape and their diameter varies from 8 nm to 17 nm. Measurement of VSM at room temperature showed that iron oxide nanoparticles have superparamagnetic properties. In vitro drug loading and release behavior of curcumin drug-loaded CS-Fe 3 O 4 nanoparticles were studied by using UV-spectrophotometer. In addition, the cytotoxicity of the modified nanoparticles has shown anticancer activity against A549 cell with IC 50 value of 73.03 μg/ml. Therefore, the modified magnetic nanoparticles can be used as drug delivery carriers on target in the treatment of cancer cells.