Linfoma don infección por VIH/SIDA Presentación de 8 casos y revisión de la literatura (original) (raw)

Introduction: Hodgkin lymphoma (HL) is a non-AIDS defining neoplasm; however, many studies have proven an increase of its incidence in patients infected by the human immunodeficiency virus (HIV). Objectives: We analyzed retrospectively the epidemiological, clinical, histopathological and immunological characteristics and the outcome of 8 HIV-seropositive patients with diagnosis of HL. Results: We evaluated 8 patients; 7 were males. The median of age was 44 years and the median of CD4 T-cell counts at the time of the neoplasm diagnosis was 115 cells/uL (56-185 range). The median of time between the onset of the symptoms and the diagnosis of HL was of 47 days; 7/8 patients presented with “B” symptoms (fever, weight loss and night sweats) and 6/8 showed stage IV of the neoplasm disease, 1 was on stage I and the another one on stage IIIs. The histopathological subtype could be determined in 6/8 subjects and was of mixed cellularity in 4, lymphocyte depletion in 1 and nodular sclerosis in 1. In 4/8 patients a combined treatment with antiretrovirals (ARV) drugs and chemotherapy could be made. The four of them undergo a long survival rate free from neoplasm disease. The overall survival rate of the whole sample was of 9 months. Conclusions: HL associated with HIV/ AIDS is characterized by its occurrence in advanced stages of the neoplasm disease, a low CD4+ T-cell counts and the marked prevalence of the mixed cellularity histopathological subtype. Combination therapy based on ARV drugs plus QT was associated with a long survival rate.