A study on the morphological spectrum of salivary gland tumors (original) (raw)
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Tropical Journal of Pathology and Microbiology, 2018
Background: Salivary gland tumors (SGTs) are rare neoplasm of head and neck region. The salivary gland tumours vary widely in histopathological appearance. Also, epidemiological data of these tumors in various parts of the world are different. And so the study of SGTs for their biology and clinical characteristics can be helpful for a better understanding. Objectives: The objective of this study was to study types and new entities, common site of distribution and histomorphological spectrum of salivary gland tumors (SGTs). Materials and Methods: It was a retrospective followed by prospective study. Pertinent clinical history like age, duration of the lesion, site of the lesion, significant family and personal history, history of associated diseases was recorded. Specimens consisted of incisional biopsies were examined microscopically by the expert pathologist. Details of specimens noted in Performa include dimensions, appearance of external and cut surface and presence of lymph nodes, their size and number. Observations: Total 70 cases of SGTs could be included in the study. Among them 56 (80%) were benign and 14 (20%) were malignant. Parotid is commonest salivary gland involved with 75.71% of all tumors, followed by submandibular with 21.42% and minor salivary glands with 1(1.4%) of salivary gland tumors. among benign tumors Pleomorphic adenoma is most common with 70% of all benign SGTs followed by Warthin tumors (7%). Among malignant tumors commonest is Mucoepidermoid carcinoma with 14.28% of all SGTs. Female preponderance was clearly found in malignan at SGTs. Conclusion: Parotid is most common site for the SGT. And pleomorphic adenoma and the Warthin tumors are the common benign tumors involve parotid gland the most. Among malignant tumors mucoepidermoid carcinoma are the commonest with female preponderance. While other carcinoma like adenoid cystic carcinoma and SCC are also common.
Histopathological Study of Salivary Gland Tumors
Background: Salivary gland tumors represent the most complex and diverse group of tumors encountered by the pathologist. Their diagnosis and management is complicated by their relative infrequency, the limited amount of pretreatment information available and the wide range of biologic behavior seen with the different pathologic lesions. It may vary from low grade tumour to high grade tumour and often fatal malignancy. These circumstances make this cancer a diagnostic and therapeutic challenge. This is a retrospective study till date done at Pathology Department, K.D. medical hospital and research centre, Mathura, India. All the cases of Salivary gland tumors, which had been recorded in a two and half year period from 2015 to 2018, were enrolled in the study. Results: Total number of cases studied were 60. Out of which 37 were benign (61.67%) and 23 were malignant (38.33%). Among benign tumours, Pleomorphic adenoma was found to be the commonest tumour. The Mucoepidermoid carcinoma was the most common malignant tumor. Females are affected more commonly than males in both groups.
Study of histomorphological patterns of salivary gland tumors
IP Innovative Publication Pvt. Ltd., 2018
Introduction: Salivary gland neoplasms though relatively rare, have a varied histological spectrum both in the benign and malignant tumors and hence, are of interest to pathologists. Aim of the study: To study the histomorphological patterns of salivary gland tumors. Materials and Methods: This was a two year four month prospective study from January 2015 to April 2017. The salivary gland specimens received in histopathology section of Department of Pathology, Government Medical College, Nizamabad, Telangana were studied for light microscopy. Results: Present study included 80 cases, with patient age ranging from 11 to 78 years and the male to female ratio was 3:1. In the present study 62.5% cases were benign and 37.5 % were malignant. Pleomorphic adenoma was the commonest benign tumor followed by Warthin’s tumor, monomorphic adenoma and basal cell adenoma. Mucoepidermoid carcinoma was the most common malignant tumor followed by adenoid cystic carcinoma, acinic cell carcinoma and carcinoma ex pleomorphic adenoma. Conclusion: Of all salivary glands, Parotid glands are most commonly affected by tumors. Pleomorphic adenoma is the most common benign tumor and Mucoepidermoid carcinoma is the most common malignant tumor in salivary glands. Keywords: Mucoepidermoid Carcinoma, Pleomorphic adenoma, Salivary gland tumors.
Primary Salivary Gland Tumors- A two years study at Nobel Medical College
Nepalese medical journal, 2019
Salivary gland tumors are a heterogenous group of neoplasms that are relatively rare but represent a wide variety of both benign and malignant histopathologic subtypes. The global incidence is 1 in 100,000 individuals and comprises less than 3% of all head and neck neoplasms. 1 The frequency of benign tumors of salivary glands is higher in females whereas malignant tumors occur more frequently in males. 2,3 The most common benign tumor is pleomorphic adenoma followed by warthin's tumor, whereas most common malignant tumor is mucoepidermoid carcinoma followed by adenoid cystic carcinoma. 2-5 Benign tumors of salivary glands are most commonly seen in 30-70 years with a mean age of 45 years and peak incidence of malignant tumor in seen in 6th and 7 th decades. 6,7 Conclusions: Benign salivary tumors are more common than malignant tumors with the most common occurrence in parotid glands. Pleomorphic adenoma is the most common benign tumor whereas; mucoepidermoid carcinoma is the most common malignant tumor in patients visiting Nobel medical college.
Histomorphological Study of Salivary Gland Neoplasms: A 2 Year Study
BACKGROUND: Of all the tissues in the human body, perhaps the salivary glands have the most histologically heterogenous group of tumors and the greatest diversity of morphologic features among their cells and tissues. This diversity combined with the fact that most surgical pathologists have limited opportunity for experience with salivary glands is the primary reason behind the difficulty caused by these diseases for many pathologists. Therefore, present study was undertaken to study the relative incidence and spectrum of histomorphological features of various salivary gland neoplasms. AIMS: The aim of this study was to evaluate the relative frequencies, types, site distribution and the histomorphology of salivary gland neoplasms. MATERIAL AND METHODS: The material for this study comprised of incisional biopsies and resected specimens of salivary gland neoplasms received in the department of pathology, J.J.M.Medical College, Davangere. In cases of parotid gland lesions, superficial parotidectomy and total parotidectomy without neck dissection was done and specimens were sent for histopathological examination. Gross examination and subsequent microscopic examination was done after staining with hematoxylin and eosin. 53 cases diagnosed histopathologically as salivary gland neoplasms were included in this two year prospective study. RESULTS: During the two years of study period 53 salivary gland neoplasms were seen. 38 cases were benign neoplasms and 15 cases were malignant. Among all neoplasms, pleomorphic adenoma was the commonest. Mucoepidermoid carcinoma was the most common malignant neoplasm. The mean age of presentation of all neoplasms was 42.74 years. The male to female ratio was 1:1.2. Most common site of occurrence was parotid gland. No intraparotid lymph nodes were observed. In all the neoplasms studied, typical histomorphological features were seen. Surgical margins were free in all the cases. CONCLUSION: It is concluded that some of our results are in harmony with those of other authors.. On the other hand, some of our results are different from published literature. Further nationwide population based survey is needed to define the epidemiology of salivary gland neoplasms.
Histopathological study of non-neoplastic and neoplastic lesions of salivary gland
IP innovative publication pvt. ltd, 2019
Introduction: Salivary gland lesions represent clinical and morphological diversity, which is a difficult task for histopathological interpretation. Classification of salivary glands lesions into non-neoplastic and neoplastic (benign and malignant tumors) is essentially based on histopathological aspect, which is important for management and predicting its prognosis. Aims and Objectives: To study histomorphological (gross and microscopic) aspect of Salivary gland lesions. To classify salivary gland lesions for therapeutic implication. To study the different epidemiological pattern with particular references to age, gender, site and its incidence. To compare and observe the results of this study with other studies Materials and Methods: This is a retrospective study done at Pathology Department, GMERS Medical College and Hospital, Sola, Ahmedabad. The specimens were fixed in 10% formalin, processed by paraffin embedding, stained with H & E and examined microscopically. Results: Out of 66 cases, 22(33%) cases are non-neoplastic and 44(67%) cases are neoplastic. Among 44 neoplastic lesions, 42(95%) cases are benign and 02(5%) cases are malignant. Parotid gland is the most common and well known site for the all salivary glands lesions. Male female ratio was 3.4:1. The mean age found was 39.5 years with age scope of 3 to 72 years. Chronic sialadenitis is the most common non-neoplastic lesion. Most common benign tumor of salivary glands is pleomorphic adenoma followed by Warthin’s tumor. The mucoepidermoid carcinoma was only recognized malignant tumor followed by undifferentiated malignant tumor. Conclusion: Owing to complex features exhibited by salivary gland lesions histopathological examination is the mainstay for final diagnosis and categorization for treatment and prognosis. Keywords: Chronic sialadenitis, Pleomorphic adenoma, Mucoepidermoid carcinoma.
Clinicopathological Analysis of Salivary Gland Tumours: An Observational Study
2019
Background: Salivary gland tumour is a comparatively sporadic and morphologically varied collection of pathologic entities. Hence; we histopathologically analyzed the salivary gland tumour in the present study.Materials & methods: The present analysis included histopathologic assessment of salivary gland neoplasms. All the biopsies received in the department were recorded. H and E stained slides were made and were assessed by experienced and certified oral pathologists. Histopathologic diagnosis were recorded in Microsoft excel sheet and were analyzed by SPSS software. Results: Biopsies of a total of 70 salivary gland neoplasms were studies in the present study. Among these, 40 were benign while the remaining 30 were malignant in nature. Total frequency of occurrence of Pleomorphic adenoma, Basal cell adenoma and Warthin’s tumour was 25.6%, 10% and 14.2% respectively. Frequency of occurrence of Adenoid cystic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma, polymorphous low...