21 ~ The Pharma Innovation (original) (raw)
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2017
In medicinal chemistry, the study of lignan is significant due to their respective nature. The lignan has obtained much more active molecule yet 1-phenyl naphthalene and its derivative has various number physiological activities. For extraction and isolation, various separation methods are designed on the basis of organic solvent and soxhlet extractor. On recent study the requirement of drogue in bulk extent so that’s why we keep designing the number of methods for synthesis of lignan i.e. 1-phenyl naphthalene and their derivatives. The naturally occurring compound shows multiple activity and side effects due to the conventional synthetic methods of lignans are developed. Those isolated and synthesized lignan derivatives are studied for physiological activity, in which 1-phenyl naphthalene and their derivatives show magnificent result towards activity.
In recent investigation for 1-phenyl naphthalene has been synthesis via friedel craft acylation and Perkin-Oglialoro reaction followed by cyclization reaction. The key precursor use for synthesis of foresaid product by β-benzoyl propionic acid (β-BPA) through friedel craft acetylating reaction by mixture of succinic anhydride, benzene and its derivative with zeolite at streamline time to obtain blended accumulation followed by work-up with cold acid-water (1:1) treatment. The obtaining accumulation on distillation to eliminate benzene liquor and obtained crude mass. It dissolve in aqueous solution of sodium carbonate (1:10) and acidification by hydrochloric acid to form crude -benzoyl propionic acid (-BPA) and their derivatives. In perkin acid synthesize by two steps in which butenolides are prepared by ß-BPA and aryl aldehyde using weak base catalyst pyridine and followed by cleavage of lactone ring methanolic base hydrolysis to form perkin acid. The perkin acid undergoes cyclization using zeolite gives 1-phenyl naphthalene. The similar contexts the 1-phenyl naphthalene derivatives are extracted from medicinal plant i.e., Cleistanthus collinus and isolated by column chromatography. These entire compounds are determined by UV-Visible spectrophotometry.
GREEN APPROACH TOWARDS THE SYNTHESIS OF 1-PHENYL NAPHTHALENE LIGNAN AND THEIR DERIVATIVES
The use of green chemistry technique reduces the chemical waste and reaction time. Recently, it has been proved in several organic synthesis and chemical transformation. In present work, synthesis of 1-phenyl naphthalene fromβ-Benzoyl propionic acid, aryl aldehyde, acetic anhydride and pyridine was carried out and it was cyclised with PPA and sulphamic acid, by using microwave irradiation. It is a three step reaction. In first step synthesis of α-arylidineγ-phenyl δ,β-butenolide by perkin reaction, in second step synthesis of α-arylidine, β-BenzoylPropionic acid by cleavage using alcoholic sodium carbonate and In third step synthesis of 1-phenyl naphthalene by cyclisation using PPA , H 2 SO 4 , Sulphamic acid has been carried out. It has been observed that microwave irradiation method produces better yield and reduces the time period compared with conventional method. The structure of 1-phenyl naphthalene was confirmed by spectral and elemental analysis.
Lignans: Insight to Chemistry and Pharmacological Applications-An Overview
Lignans are widely distributed in the plant kingdom and have been found in species belonging to more than seventy families. These are found in several foods, mostly in seeds, beans and berries. Sesame seed lignans are perhaps best known for their positive health effects as antioxidants. In recent times, lignans attracted much interest in the researchers due to their wide range of biological applications and their utility as useful synthons. This review describes up to date developments in the lignan chemistry, with a more emphasis on their natural sources, methods developed for synthetic analogues and critical discussion on biological activities.
Cleistanthus collinus is a poisonous plant as they required special treatment for their safety measure for collection and preservation by herbarium specimen. Aryl naphthalene has numerous physiological activities and it is present in plant. The present investigations focus for solid-liquid extraction of plant which extract derivative of lignan by soxhlet extractor method. Optimization of types of solvents with respect to polarity alcoholic extract and defated petroleum ether has effective solvent. Quantification of solvent volume for extracting compounds from plant (1gm per 15 ml). Determination of effective time for respective solvent for extraction.
An update on bioactive plant lignans
Natural Product Reports, 2005
Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C 6 -C 3 ) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities, and comprises the data reported in more than 100 peer-reviewed articles, so as to highlight the recently reported bioactive lignans that could be a first step towards the development of potential new therapeutic agents.
Lignans: a versatile source of anticancer drugs
Beni-Suef University Journal of Basic and Applied Sciences
Background Cancer is considered as the second deadliest disease globally. Plants have continuously offered unique secondary metabolites with remarkable biological applications. Lignans have gained great importance due to their biological activity. Previous studies revealed that the most remarkable bioactivity of lignan class of molecules is anticancer. They are derived from the oxidative dimerization of two phenylpropanoid units. This review covers the isolated anticancer lignans and their mechanistic aspects. Main body A bibliographic investigation was performed by analyzing the information available on anticancer lignans in the internationally accepted scientific databases including Web of Science, SciFinder, PubMed, Scopus, and Google Scholar. In this review we have tried to sum up the isolated anticancerous lignan, its source, active plant part, extract and various cell lines used to establish different studies. Here we have included a total number of 113 natural lignans. Many s...