Comparison of hepatic and renal parameters between Diabetic and Non Diabetic Individuals of Dakshina Kannada: A cross sectional study (original) (raw)

Objectives: To compare fasting plasma glucose levels, HbA1c, hepatic and renal parameters in diabetes mellitus (DM) subjects and compare the values with healthy controls. Materials and Methods: A total of 67 (n=67) reports were collected from Central laboratory, Yenepoya Medical College Hospital, Mangaluru from January 2018 to June 2018. Patients with FBS values more than 126mg/dl or HbA1c more than 6.5% who have been advised LFT and RFT by the physician were included in diabetic group (34) and other 33 reports of LFT & RFT with normal FBS & HbA1c levels included in non-diabetic group. All the data viz. FBS, HbA1c, Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, S GOT, SGPT, Blood Urea and S. creatinine values were entered in excel sheet and subjected for statistical analysis. Results: Intergroup comparison of biochemical parameters was done by Non-Parametric test (Mann- Whitney) and Pearsons Chi square tests. The values fmean  inter quartile range (IQR)g of FBS, HbA1c, Total Bilirubin, Direct Bilirubin, Indirect Bilirubin, SGOT, SGPT, Blood urea and S. Creatinine in diabetic group are 184.5mg(171-274.5 ), 8.9% (7.2-10.5), 0.7mg (0.5-0.8), 0.3mg(0.2-0.4), 0.4mg (0.3-0.4), 28U (21.5-33), 25.5U(20-32.25), 30.5mg (21.75-38) and 0.9mg (0.8-1) respectively obtained in Mann-Whitney test. Similarly, values of 96mg (78-103), 5.8% (5.3-5.9), 0.5 mg (0.4-0.7), 0.2mg (0.2-0.2), 0.3mg(0.2- 0.45), 23U (20-28), 24U (19-36), 18mg(16-21), and 0.7mg(0.6-0.8) were respectively noted in non-diabetic group. The Mann-Whitney test showed significant difference in all the parameters except in Indirect Bilirubin, SGOT, and SGPT levels between two groups (p<0.05). However, Pearson Chi square test revealed there is revealed no significant difference in these parameters between diabetic and non-diabetic group with p >0.05. Conclusion: The present study suggests that there is no statistical significant difference in hepatic and renal parameters between diabetic and non-diabetic groups with respect to Chi-square test. Many previous studies have shown significant organ dysfunction in diabetic individuals, but our study result revealed there is no difference in the biochemical parameters of diabetic and non-diabetic individuals.