ANTI-INFLAMMATORY AND ANTIPYRETIC PROPERTIES OF THE RHIZOME OF COSTUS SPECIOSUS (KOEN.) SM (original) (raw)
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Anti-inflammatory and anti-noceceptive action of the crude extracts of Costus specious on rodents
Oriental Pharmacy and Experimental Medicine, 2008
The effect of alcoholic extracts of Costus specious (Family: Zingiberaceae) was evaluated in experimental models of pain and inflammation. Oral administration of 100, 200 and 300 mg/kg of C. specious extracts were used for the above study. Crude extracts of C. specious (300 mg/kg dose) showed maximum time needed for the response against thermal stimuli (7.242 ± 0.532 s) which is comparable to diclofenac sodium (8.471 ± 0.257 s) in the hot plate test. The MPH (Maximum Possible Analgesia) has been found to be 14.285 for 300 mg/kg dose of the crude extract while the MPH for diclofenac was 15.857 after 60 min of administration in the hot tail-flick method. The crude extract at 300 and 200 mg/kg doses showed significant reduction in acetic acid induced writhings in mice with a maximum effect of 59.661% reduction at 300 mg/kg dose which is comparable to standard diclofenac sodium (73.4%). Alcoholic extract of C. specious showed significant inhibition in serotonin and egg albumin induced hind paw oedema in rats at 100, 200 and 300 mg/kg of the crude extracts respectively (Serotonin induced edema 44.22; 53.75; 58.51%; egg albumin induced edema-41.317; 53.892; 59.880% inhibition after 4 h respectively). The antiinflammatory effects showed by the extract were comparable to that of standard indomethacin 5 mg/kg (Serotonin induced edema 77.56%; egg albumin induced edema 77.844% inhibition after 4 h). These results suggest that the extract possesses both the anti-inflammatory and analgesic activity on mice and rat model.
Evaluation of in-vivo antiarthritic potential of methanolic extract of Costus speciosus rhizome
Journal of Applied Pharmaceutical Science, 2015
To evaluate anti-arthritic potential of methanolic extract of rhizome of Costus speciosus Koen. Methods: The powdered drug was extracted with 80% methanol. The crude extract was subjected to phytochemical investigation and was evaluated for its anti-arthritic potential by freund's complete adjuvant induced arthritis model in adult wistar albino rats. Determination of different parameters like arthritic score, arthritic index, paw thickness, body weight, and pain, altered liver enzymes and biochemical estimation like, nitric oxide level and Plasma TNF-α level was done. Finally, radiological estimation and histopathology of tibio tarsal joints was performed. Statistical analysis was performed using one way ANOVA followed by Dunnet's test at different p-values. Results: Phytochemical study revealed the presence of flavonoids, phenolic compound, saponins and carbohydrates. For different parameter mentioned above, anti-arthritic activity shown by prophylactic high dose test extract (200 mg/kg) was as potent as standard drug Indomethacin (10 mg/kg). The effect of Prophylactic low dose extract (100 mg/kg) and therapeutic high dose extract (200 mg/kg) was less than that of Indomethacin (10 mg/kg). Furthermore, Therapeutic low dose extract (100 mg/kg) was not effective. Conclusions: The obtained results indicate that Costus speciosus rhizome extract possess significant anti-arthrtic potential.
Evaluation of some bioactive effect of phenolic compounds in Costus speciosus rhizome extract
IRAQI JOURNAL OF SCIENCE, 2018
This work was evaluated the antioxidant, antibacterial and cytotoxic activity of Costus speciosus rhizomes methanol extract. The FLC analysis showed the presence of five compounds in the methanol extract of C. speciosus rhizomes. These compounds were Quercetin (5.2mg/ml), Rutin (6.02mg/ml), Luteolin, (18.3mg/ml), Kaempherol, (11.34mg/ml) and Coumarin (1.41mg/ml). The maximum antioxidant activity of the extract was at concentration 1000 μg/ml with free radical scavenging activity approximately 67.5%. It was less than standard ascorbic acid 85.5% and Gallic acid 90% with significant difference (p≤0.05), with no significant difference in comparison with standard TBA 68.5%. The IC50 of extract was 3093μg/ml, while the IC50 of ascorbic acid, Gallic acid and TBA were (277.2, 364.5 and 601.3 μg/ml) respectively. The extract revealed influential growth inhibition for all bacteria used in this experiment. The extract was moderately effective at concentration 400 μg/ml of extract with inhibitory activity 50.7 % on MCF-7 cell line and IC50 139.1 μg/ml.
Antimicrobial Activity of Methanolic Extract of the Rhizomes of Costus igneus
2014
The whole plant of Costus igneus commonly known as ‘insulin plant’ a member of Costaceae family is used for it anti-diabetic property. It was learnt that no substantial work on antimicrobial activity rhizomes of Costus igneus was carried out. Hence an effort was made to investigate the antimicrobial activity of the methanolic extract of rhizomes of Costus igneus. The rhizomes were exhaustively extracted by maceration with methanol for three days. After three days, methanol layer was decanted off and the concentrate was evaporated to dryness. The antimicrobial activity was evaluated using disc diffusion method and effect of concentration of extract on growth of bacteria culture was carried out by tube dilution technique. The methanolic extract was found to have significant activity against both gram-positive-Staphylococcus aureus and Bacillus subtilis and gram-negative bacteria- Escherichia coli, Pseudomonas aeruginosa and Salmonella typhimrium and no antifungal activity against both...
EVALUATION OF MEDICINAL ACTIVITES OF COSTUS SPECIOSUS
The aim of the present work is to evaluate the antioxidant, anti-inflammatory and an anti-viral activity of Costus speciosus leaves extract through in vitro bioassay analysis. Antioxidant activity was studied by in vitro biochemical assays, anti-inflammatory by human RBC membrane stabilisation in vitro assay and anti-viral through haemagglutination and anti-haemolysis of human RBCs methods. The results were found to be positive for all the assays and reveal the use of Costus speciosus as a good herbal source of antioxidant, anti-inflammatory and anti-viral agent. TLC fingerprinting data reveals that the positive results of Costus speciosus leaves extract for medicinal properties may be due to presence of separated phytochemicals.
Phytochemical Screening and Antioxidant Activity of Rhizome Extracts of Costus speciosus (Koen)
Journal of Academia and Industrial Research (JAIR), 2014
Abstract :Costus speciosus is an erect perennial herb belonging to family Costaceae, an important medicinal plant widely used in several indigenous medicinal formulations. Presently, these plants could be collected from wild habitat only. Due to indiscriminate collection from natural habitat it has become endangered. In the present investigation, the phytochemical and antioxidant activity of the rhizome extracts of Costus speciosus were evaluated. Phytochemical screening indicated that, rhizomes are rich in a variety of primary and secondary metabolites such as carbohydrates, alkaloids, vitamin C, vitamin E, flavonoids, phenols, glycosides, saponins and minerals like Zn, Cu, Mn, Se and Fe. The DPPH antiscavenging activity of aqueous extract was 9.98% lower than those of methanol (78.03%), chloroform (18.33%) and acetone (30.02%) extracts. The present findings for flavonoids and minerals suggested that their contents are responsible for significant antioxidant activity in all extracts. Keywords: Costus speciosus, phytochemicals, antioxidant, rhizome, secondary metabolites, flavonoids.
Antibacterial activity in the Rhizome extracts of Costus speciosus (Koen)
Hexane, methanol and water extracts of leafand rhizome extracts ofCostus speciosus used by Indian traditional healers for treating skin diseases, diabetes,jaundice, snake bites and I or anti-inflammatory properties was screened for in vitro antibacterial activities against pathogens isolated from infected bum patients For evaluating antibacterial activity, the disc-diffusion assay was used against bum pathogens. Minimal inhibitory concentration values were determined with a microdilution assay. No antibacterial activity was recorded with water extracts. The disc-diffusion method showed significant zone oflysis against all the pathogens studied and results are comparable to the conventional antibi otic cream namely Silver Sulphadiazine (SSD).
Journal of Ayurveda and Integrative Medicine, 2012
Objective: Costus speciosus Koen. (Keu, Crape ginger), an ornamental plant, widely distributed in India is traditionally used as astringent, aphrodisiac, purgative, anthelmintic, depurative, febrifuge and expectorant. The plant is also used in rheumatism, dropsy, urinary diseases and jaundice. The purpose of this study is to evaluate the anti-arthritic activity of the methanolic extract of the aerial parts of Costus speciosus (CS) in experimental animal models. Materials and Methods: The powdered drug was subjected to successive solvent extraction, with solvents in increasing order of polarity to obtain the methanolic extract of the aerial parts of the plant. CS was evaluated for anti-arthritic action by Freund's adjuvant induced arthritis test in adult Albino rats (150-200 gm). Rats were injected 0.1 ml of complete Freund's adjuvant into the planter region of the left hind paw. Statistical analysis was performed using One way analysis of variance (ANOVA) followed by Bonferonni test. P<0.05 was considered statistically significant. Results: The methanolic extract of CS in doses of 400 and 800 mg/kg showed 75.50% and 68.33% protection against increase in paw edema, respectively. CS showed dose-dependent action in all the experimental models. Conclusion: The present study indicates that CS has significant anti-arthritic properties.
Journal of Pharmaceutical Research International
More than 80% of the population in Africa by the World Health Organization (WHO) leans on endogenous knowledge to solve their primary health care problems. In this study, we examined the relevance of Costus afer Ker Gawl, a plant called ginger lily, spiral ginger or bush cane. It is believed to be used in traditional medicine practice (TMP) to treat and manage many conditions including diabetes mellitus, stomach ailments, arthritis, inflammation. These alleged traditional incited large researchers to conduct studies on the plant to amass scientific evidence. However, these results are sparse, and thus, an inventory through the present search using online search engines such as Google Scholar, PubMed, Science Direct, Web of Science, Scopus and Chemical s for the period from 1990 to 2021; provides a bibliographic actualization on the plant, taking into account its traditional uses, phytochemical and nutritional constituents, pharmacological activities and toxicological effects. The on...