ANTI-INFLAMMATORY AND ANTIPYRETIC PROPERTIES OF THE RHIZOME OF COSTUS SPECIOSUS (KOEN.) SM (original) (raw)

Abstract

Rhizome of Costus speciosus has been traditionally used for treating inflammatory and painful conditions. The objective of the present study was to provide a scientific basis for the traditional use. The ethanolic extract of the rhizome of Costus speciosus possesses anti-inflammatory and antipyretic properties. Anti-inflammatory property was studied in carrageenan induced paw edema and cotton pellet induced granuloma formation. Significant anti-inflammatory effect was found against carrageenan induced edema formation in rats at a dose of 800 mg/kg and against cotton pellet granuloma formation in rats at doses of 400 mg/kg and 800 mg/kg. The antipyretic property was studied in yeast-induced pyrexia in rats. The antipyretic effect was only minimal and was observed only at 800 mg/kg dose.

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What specific alkaloids were identified in Costus speciosus rhizomes?add

The study confirmed the presence of alkaloids, saponins, carbohydrates, and phytosterols through preliminary phytochemical screening.

How effective is Costus speciosus against carrageenan-induced edema?add

The ethanolic extract significantly inhibited edema development at doses up to 800 mg/kg, showing about 63% effect of Acetyl salicylic acid.

What dosage of Costus speciosus showed antipyretic activity in animal studies?add

A mild reduction in rectal temperature was observed at 800 mg/kg dose, with effects persisting for 270 minutes post-administration.

What method was used for the extract from Costus speciosus rhizomes?add

The extract was obtained using the Soxhlet method with 50% ethanol, resulting in a yield of 3.9%.

How does Costus speciosus compare with standard anti-inflammatory treatments?add

At 400 mg/kg and 800 mg/kg doses, the extract's effect on granuloma formation was comparable to that of Hydrocortisone.

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References (23)

  1. Sivarajan VV, Balachandran I, eds. Ayurvedic drugs and their plant sources. 1st ed. Madras: Oxford and IBH Publishing Co Pvt Ltd; 1994:108.
  2. Warrier PK, Nambiar VPK, Ramankutty C, eds. Indian Medicinal Plants, a compendium of 500 species. Vol. 2. 1st ed. Madras: Orient Longman Ltd; 1994: 201.
  3. Bhattacharya SK, Parikh AK, Debnath PK, et al. Anticholineste- rase activity of Costus speciosus alkaloids. Indian J Pharmacol.1972; 4(3):178-9.
  4. Bhattacharya SK, Parikh AK, Debnath PK, et al. Pharmacological studies with the alkaloids of Costus speciosus (kemuka). J Res Indian Med. 1973; 8(1):10-9.
  5. Dasgupta B, Pandey VB. A new Indian source of diosgenin: Costus speciosus. Experientia. 1970; 26 (5):475-6.
  6. Singh UP, Srivastava BP. Antifungal activity of steroid saponins and sapogenins from Avena sativa and Costus speciosus. Naturalio Rio Claro. 1992; 17:71-7.
  7. Ghosh MN. Fundamentals of Experimental Pharmacology. 2nd ed. Calcutta: Scientifi c Book Agency; 1984:155.
  8. Turner RA. Screening methods in Pharmacology. New York, NY: Academic Press; 1965:302.
  9. Sheth UK, Dadkar NK, Kamath UG. eds. Selected topics in experimental pharmacology. 1 st ed. Bombay: Kothari Book Depot; 1972: 33,126.
  10. Turner RA. Screening methods in Pharmacology. New York, NY: Academic Press; 1965:26.
  11. Winter CA, Risley EA, Nuss GW. Carrageenan-induced edema in hind paw of the rat as an assay for anti-infl ammatory drugs. Proc Soc Exp Biol Med. 1962; 111: 544-7.
  12. Cashin CH, Dawson W, Kitchen EA. The pharmacology of benoxaprofen (2-[4-chlorophenyl]-alpha-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with antiinfl ammatory activity apparently unrelated to inhibition of prostaglandin synthesis. J Pharm Pharmacol. 1977; 29(6):330-6.
  13. Singh H, Ghosh MN. Modifi ed plethysmometer for measuring foot volume of unanesthetized rats. J Pharm Pharmacol. 1968; 20(4):316-7.
  14. D'Arcy PF, Howard EM, Muggleton PW, et al. The anti-infl ammatory action of griseofulvin in experimental animals. J Pharm Pharmacol. 1960; 12:659-65.
  15. Bush IE, Alexander RW. An improved method for the assay of anti- infl ammatory substances in rats. Acta Endocrinol. 1960; 35:268-76.
  16. Winter CA, Risley EA, Nuss GW. Anti-infl ammatory and antipyretic activities of indomethacin, l-(p-chlorobenzoyl)-5-methoxy-2-methyl- indole-3-acetic acid. J Pharmacol Exp Ther. 1963; 141:369-76.
  17. Teotino UM, Friz LP, Gandini A, et al. Thio derivatives of 2,3-dihydro- 4h-1,3-benzoxazin-4-one. Synthesis and pharmacological properties. J Med Chem. 1963; 6:248-50.
  18. Gujral ML, Kohli RP, Bhargava KP, et al. Antipyretic activity of some indigenous drugs. Indian J Med Res. 1955; 43(1):89-94.
  19. Roszkowski AP, Rooks WH, Tomolonis AJ, et al. Anti-infl ammatory and analgetic properties of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen). J Pharmacol Exp Ther. 1971; 179(1):114-23.
  20. Vogel GH, Vogel WH, eds. Drug Discovery and Evaluation: pharmaco- logical assays. 1 st ed. Berlin: Springer; 1997:416.
  21. Loux JJ, De Palma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicol Appl Pharmacol. 1972; 22(4):672-5.
  22. Larsen GL, Henson PM. Mediators of infl ammation. Annu Rev Im- munol. 1983; 1:335-59.
  23. Brooks PM, Day RO. Nonsteroidal antiinfl ammatory drugs-differenc- es and similarities. N Engl J Med. 1991; 324(24):1716-25.