Association of Vitamin D and HbA1c in Type II Diabetes Mellitus Patients (original) (raw)
Related papers
Correlation between Vitamin D and HbA1C in Type 2 Diabetic patients
Background: The role of Vitamin D in various metabolic disorders including Diabetes Mellitus has been explored. Vitamin D has sparked widespread interest in the pathogenesis and prevention of diabetes. Aim: This study evaluates the correlation between Vitamin D status and Glycated haemoglobin in Type 2 Diabetes Mellitus. Material and methods: This study was a prospective case control study with 50 cases and 50 controls. Results: Vitamin D insufficiency was observed in both cases and controls. The mean Vitamin D values in cases and controls were 13.89+6.28ng/ml and 17.30+11.13ng/ml respectively. Chi square test shows there is significant statistical difference in Vitamin D levels between cases and controls but inverse correlation between Vitamin D and HbA1C which was not found statistically significant. Conclusion: Present study shown the inverse correlation between Vitamin D and HbA1C but it didn't came statistically significant, may be due to small sample size. Hence present study cannot establish the role of Vitamin D in preventing Diabetes Mellitus but it is highly recommended for Vitamin D screening in diabetic patients on a regular basis.
Journal of Evolution of Medical and Dental Sciences
BACKGROUND The role of vitamin D in type 2 diabetes is suggested by a seasonal variation in glycaemic control. It was reported in patients with type 2 diabetes being worse in winter, which might be due to hypovitaminosis D as a result of reduced exposure to sunlight. Aims and Objectives-(I) To estimate the plasma vitamin D3 level in type 2 diabetes mellitus. (II) To find out association between vitamin D3 and HbA1c level. (III) Correlation between serum vitamin D3 level and diabetic cardiovascular complications. MATERIALS AND METHODS A cross-sectional study was conducted among 100 type 2 diabetes patients who were selected from medicine ward and diabetes clinic. The descriptive statistics like percentages, mean and median were calculated. The inferential statistics like Chi-square statistics and Spearman's correlation were performed for analysis of data. RESULTS HbA1c was increased in majority of patients (71.0%). Majority of the respondents were having low vitamin D levels. There was gross scattering of the dots indicating that poor correlation between HbA1c and Vitamin D levels. The Spearman's Rho was found to be only 0.092 (poor correlation) and this finding was not significant (p= 0.361). There was poor correlation between HbA1c and Vitamin D3 levels and Vitamin D3 level was not correlated with age and hypertension. CONCLUSION The 25-(OH) D3 concentrations were low in 90% of the diabetic patients. There was an inverse association between the serum concentration of 25-(OH) D3 and type 2 diabetes, thereby suggesting a protective role of vitamin D against the development of the disease.
European Journal of Cardiovascular Medicine, 2023
Introduction: Diabetes mellitus is one of the common non-communicable diseases in India. Role of vitamin D is described in diabetes mellitus in multiple studies owing to its facilitation/inhibition of transcription factor and immune-modulator property. Aim: To study the association between vitamin D level and HbA1C level. Methods: It was an analytical observational case study. Patients of type 2 diabetes mellitus were included in the study. All routine lab parameters were done and patients were evaluated for diabetic retinopathy and neuropathy. Statistical analysis was done by pearson correlation test, fisher's exact test and ANOVA. Linear regression analysis was also done. Results: 119 patients were included in the study. Vitamin D deficiency was found in 77 patients (64.71%). Significant association was found between vitamin D deficiency and younger age. (p = 0.012) Negative correlation was present between vitamin D level and HbA1c. Vitamin D deficiency was found to be significantly associated with high HbA1c (p = 0.024). Conclusion: Vitamin d deficiency in type 2 diabetes mellitus is associated with poor glycemic control.
VITAMIN D3 LEVELS IN DIABETES MELLITUS AND ITS CORRELATION WITH HbA1C LEVELS.
Background- Vitamin D3 is known for its calcium absorption and bone metabolism; but now been recognized as an accessible predictor, risk factor and biomarker of type 2 diabetes mellitus (T2DM). Aim- The aim of the study is to determine serum vitamin D3 levels in T2DM patients and ascertain its correlation with HbA1c. Setting and design- This is a cross-sectional study through screening of patients with T2DM attending the OPD/ indoor of SGRDIMSR, Amritsar. Material and method- With prior informed consent, 100 diabetic patients were examined for complications of diabetes and investigated for HbA1c, serum calcium and vitamin D3 levels in addition to routine investigations. Vitamin D3 levels were determined and relation with HbA1c levels was established. Results- Among the 100 T2DMpatients, 46% had deficiency, 22% had insufficiency and 32% had sufficiency of vitamin D3. The mean HbA1c value was 7.74 ? 1.63% in vitamin D sufficiency, 9.83 ? 2.02% in insufficiency, and 9.91 ? 2.5% in deficiency making the correlation highly significant (p <0.0001). The fasting plasma glucose levels were significantly higher in deficient group (156.76 mg/dl) as compared to insufficient (147.91mg/dl) and sufficient group (138.28mg/dl). The above observations suggest a highly significant correlation between the two (p <0.0001). There was established a highly significant inverse correlation between vitamin D3 and HbA1c and FPG levels. Conclusion- Vitamin D3 is a potential risk factor for diabetes mellitus and has a role to play in its pathogenesis. Not only a patient should be screened for serum vitamin D3 levels as a possible risk factor but also as a potential beneficial role of serum vitamin D3 supplementation in improving glycemic status in patients with diabetes mellitus.
Vitamin D status Association with newly diagnosed Type2 Diabetes Mellitus: A Case Control Study
Fayoum University Medical journal, 2018
Diabetes mellitus is one of the most common metabolic diseases in the world that can affect nearly every organ system in the body. Vitamin D has sparked widespread interest in the pathogenesis and prevention of diabetes. The aim of study; to investigate vitamin D level in type 2 diabetes and controls. A retrospective case control study with 47 newly diagnosed diabetic patients aged (35-70 years) and 54 controls matching age±5years and gender. Measuring HbA1c, FBG, assay serum 25(OH) D level were done for patients and/or controls. Results of current study, showed a more severe vitamin D deficiency in newly diagnosed diabetes than controls (46.8% vs.33.3%) and difference between vitamin D level in newly diagnosed diabetes compare to controls was not statistical significant (p=0.108). Conclusion: no statistical significant difference between newly diagnosed diabetes and controls concerning to vitamin D level.
A Study on Vitamin D Levels in Patients with Type II Diabetes compared to Normal Subjects
2015
Vitamin D deficiency is highly prevalent in the world and in Asian countries including Iran. There is a great deal of evidence suggesting the relationship between serum Vitamin D level and prevalence of type II diabetes. The objective of this study was to assess the serum level of Vit D in diabetics and non-diabetics and to compare the results of the two groups. This descriptive epidemiological study was carried out on 79 participants including 40 diabetic patients and 39 healthy individuals. The participants were randomly selected from the participants of the Ahwaz Metabolic Syndrome project. The serum vitamin D level, FBS, PTH, and insulin level were measured in the participants. The insulin resistance (HOMA-IR index) was also calculated for all participants. In general, 97.1% of healthy participants and 88.1% of diabetics were diagnosed with vitamin D deficiency or inadequacy. No difference was observed between the levels of vitamin D in the two groups (P=0.23). There was a stati...
Pakistan Journal of Medical Sciences, 2017
Objective: To study the effect of Vitamin D supplementation on reduction in level of HbA1 in patients recently diagnosed with diabetes mellitus Type II having asymptomatic Vitamin D deficiency. Methods: This randomized control trial was conducted at East Medical Ward Mayo Hospital Lahore for 6 months from January 01 2016 to June 30, 2016. 114 Patients were included through non probability purposive sampling technique. Informed consent and demographic information was collected. Patients were divided in two groups by randomization through tossing a coin. GroupA patients received Metformin tablet alone at 500 mg after dinner and Group-B patients were treated with same dosage of Metformin along with oral vitamin D at 200,000 IU monthly for three months. Blood sample was obtained at baseline, 3 months and 6 months of initiation of therapy. All samples were sent to the laboratory for complete blood count, blood sugar fasting, serum calcium, serum phosphorous, serum alkaline phosphatase, HbA1c and serum 25 Hyroxy Vitamin D (S-25(OH) D) levels and iPTH. Data entry and analysis was done by using SPSS 20. Results: The mean age of patients in metformin group was 42.37±4.59 years while mean age of patients in combination group was 43.33±4.86years. Males were 45.6% and females were 54.4% in metformin group while in combination group, 36.8% were males' and 63.2% were females'. At baseline, in metformin group, mean Vitamin D level was 17.09±1.73mg/dl and in combination group, mean Vitamin D level was 16.49±1.56mg/dl. The difference was insignificant (p>0.05). On 2nd visit, combination group mean Vitamin D was 29.04±3.96mg/dl. At baseline, 1 st and 2 nd visit, in metformin group, mean HbA1c was 7.59±0.47%, 7.46±0.25% and 7.30±0.29%. At baseline, 1 st and 2 nd visit, in combination group, mean HbA1c was 7.71±0.19%, 7.57±0.21% and 7.43±0.26%. The difference was insignificant (p>0.05) at baseline while significant on later follow-ups (P<0.05). Conclusion: Vitamin D supplementation improved the glycemic control but substantial reduction in HbA1c was statistically insignificant in both groups.
Analysis of Vitamin D in Patients with Diabetes Mellitus Type 2
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
Diabetes Mellitus is a metabolic disease which is still a public health problem till now. World Health Organization (WHO) and International Diabetes Federation (IDF) predict an increase in the number of diabetics which become one of the global threats. Some evidences showed that vitamin D deficiency might influenced in pathogenesis of Type 2 Diabetes Mellitus that caused by insulin resistence and dysfunction of pancreatic beta cell. The objectives of this study is To analyze Vitamin D levels in Type 2 Diabetes Patients that consist of prediabetic group, controlled Type 2 Diabetes Mellitus Group, and uncontrolled Type 2 Diabetes Mellitus. The method used is a cross sectional study. During the study period, a total of 93 samples were obtained which met the study criteria. The sample consist of 33 prediabetic subjects, 30 controlled Type 2 DM subejcts, and 30 uncontrolled Type 2 DM. The study sample consist of 49(52,7%) men and 44(47,3%) women with minimum age 20 years and maximum 79 y...
2019
Vitamin D as an immunomodulator plays an important role in controlling glycemic levels and decreasing diabetic complications. HbA1c is a marker of glycemic control which is known to have a correlation with vitamin D. This study aimed to determine the differences of serum vitamin D levels and glycemic index in patients with type 2 DM. The design of this study was a cross-sectional study and was performed in the Adam Malik Hospital from December 2017 until March 2018. Type 2 diabetes mellitus patients were classified based on HbA1c levels into controlled (HbA1c <7%) and uncontrolled diabetes mellitus (HbA1c ≥ 7%). Serum vitamin D levels were measured using the Enzyme-Linked Fluorescent Assay (ELFA) method. Differences of vitamin D levels among controlled and uncontrolled type 2 diabetes mellitus were statistically analyzed using an independent t-test, and the differences of HbA1c levels were analyzed using the Mann-Whitney-U test. Forty-five patients with type 2 DM were divided int...
Association of serum Vitamin D level with Glycemic Status in Patients of Type 2 Diabetes Mellitus
Endocrinology & Metabolic Syndrome
Introduction: For development of Type 2 Diabetes mellitus, Vitamin D is thought to be a risk factor. Various studies have established the fact that Vitamin D replenishment improves glycemic status and insulin secretion in patients with Type 2 Diabetes mellitus with established hypovitaminosis D. This study was done to find out the degree of association between glycemic status and vitamin D levels in type 2 Diabetes Mellitus patients in a tertiary care center. Patient and methods: The study was done in the Department of Biochemistry, SCB Medical College, and Cuttack 48 patients of type 2 Diabetes Mellitus were taken as cases 42 healthy subjects were taken as controls. Biochemical parameters like FBS, PPBS, Urea, Creatinine, HbA1c, Lipid profile parameters were measured in both cases and controls. Results: The serum urea and creatinine levels were significantly elevated in complicated type 2 Diabetes mellitus patients as compared to healthy controls. Serum cholesterol, triglycerides, LDL Cholesterol levels also showed significant increase Vitamin D and FBS levels showed a significant negative correlation in cases and vitamin D levels were decreased in cases as compared to controls. Conclusion: As Vitamin D and FBS levels showed a significant negative correlation, and vitamin D levels were decreased in cases as compared to controls, so it can be proved that vitamin D can lead to good glycemic control and hypovitaminosis D can thereby lead to Type 2 Diabetes Mellitus.