Ethnicity versus Climate: The Impacts of Genetics and Environment on Rosacea Epidemiology and Pathogenesis (original) (raw)
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Risk factors associated with rosacea
Journal of the European Academy of Dermatology and Venereology, 2010
Background Although rosacea is a common disease, the cause of disease is still a mystery -Helicobacter pylori infection, genetic predisposition, climatic factors, and detrimental habits are implicated as triggers of rosacea.
Prevalence of rosacea in the general population of Germany and Russia - The RISE study
Journal of the European Academy of Dermatology and Venereology : JEADV, 2016
There is an unmet need for general population-based epidemiological data on rosacea based on contemporary diagnostic criteria and validated population survey methodology. To evaluate the prevalence of rosacea in the general population of Germany and Russia. General population screening was conducted in 9-10 cities per country to ensure adequate geographic representation. In Part I of this two-phase study, screening of a representative sample of the general population (every fifth person or every fifth door using a fixed-step procedure on a random route sample) was expedited with use of a questionnaire and algorithm based on current diagnostic criteria for rosacea. Of the subjects that screened positive in the initial phase, a randomly selected sample (every third subject) t`hen underwent diagnostic confirmation by a dermatologist in Part II. A total of 3052 and 3013 subjects (aged 18-65 years) were screened in Germany and Russia respectively. Rosacea prevalence was 12.3% [95%CI, 10....
Rosacea and Chronic Systemic Diseases: Case-ControlStudy in Saudi Arabia
2020
Objective: We sought to examine the association between rosacea and systemic comorbidities in patients attending the dermatology clinic at King Fahd Hospital of the University in Al-Khobar during a 14-month period (February 2016 to May 2017). Methods: This was a prospective single-center case-control study conducted in the dermatology department of King Fahd Hospital of the University (KFHU) during a 14-month period. Self-administered questionnaires were distributed to rosacea patients and controls. The questionnaires examined demographic data, current comorbidities, family histories, and lifestyles. Study limitations were report and recall biases, which are major limitations of self-reported questionnaires. Results: A total of 76 patients (38 cases and 38 controls) of Arabic origin were recruited in the study. The mean age was 33.2 years for the cases and 27.4 years for the controls. Positive p values were seen in family histories of rosacea, photosensitivity, and food allergies. H...
Journal of Translational Medicine and Research, 2016
Objectives: Rosacea is currently defined as an inflammatory cutaneous disease without systemic echoes. The objective of our paper is to review the published articles to confirm our belief that rosacea is associated to or can predispose to various diseases, mainly inflammatory diseases. Material and methods: Review all the papers published in the last two decades in PubMed, Google Academic and Medscape databases, linking rosacea and various disorders of the body systems. Results: We found that rosacea is associated to several illnesses of major systems (gastrointestinal, cardiovascular, respiratory) and that there are also links between rosacea and immune system disorders and psychiatric diseases. Rosacea clinical course can be influenced by various drugs prescribed for the previous mentioned diseases. Conclusions: Rosacea should no longer be considered a localized cutaneous condition but rather a complex pathology with systemic reverberation. Patients suffering of severe forms of rosacea for a long period of time should have a careful evaluation of body systems.
Journal of Dermatological Treatment
Objective: To characterize rosacea features suitable for identification of high-burden (HB) subjects in clinical practice. Design: Global online survey with subjects recruited using an online panel from the United States, Canada, Italy, United Kingdom, Germany and France. Subjects self-reported a physician's diagnosis of rosacea. Measurements: HB subjects were defined as those with !3/4 domains (quality of life, lifestyle adaptation, time trade-off, willingness to pay) greater than the median. Group characteristics were analyzed and multivariate-logistic modeling used to investigate factors most associated with HB. Results: 710 subjects completed the survey, including 158 HB subjects. HB was observed in all selfdeclared rosacea severities. HB subjects were more likely to spend more time daily on skin care and experienced approximately double the impact of health problems on work productivity in the past 7 days (p < .01). In the past 12 months, HB subjects were more likely to have at least one visit to the emergency room (41.8% vs 11.2%; p < .01). In the multivariate risk analysis, factors most associated with HB included rosacea severity, impact of health problems on regular daily activities and age at first symptoms. Conclusion: Rosacea has a distinct subset of HB subjects who can be successfully characterized.
BACKGROUND: Rosacea is currently diagnosed by consensus-defined primary and secondary features and managed by subtype. However, individual features (phenotypes) can span multiple subtypes, which has implications for clinical practice and research. Adopting a phenotype-led approach may facilitate patient-centred management. OBJECTIVES: To advance clinical practice by obtaining international consensus to establish a phenotype-led rosacea diagnosis and classification scheme with global representation. METHODS: Seventeen dermatologists and three ophthalmologists used a modified Delphi approach to reach consensus on statements pertaining to critical aspects of rosacea diagnosis, classification and severity evaluation. All voting was electronic and blinded. RESULTS: Consensus was achieved for transitioning to a phenotype-based approach to rosacea diagnosis and classification. Two features were independently considered diagnostic for rosacea: persistent, centrofacial erythema associated with periodic intensification; and phymatous changes. Flushing, telangiectasia, inflammatory lesions and ocular manifestations were not considered individually diagnostic. The panel reached agreement on dimensions for phenotype severity measures and established the importance of assessing the patient burden of rosacea. CONCLUSIONS: The panel recommended an approach for diagnosis and classification of rosacea based on disease phenotype. This article is protected by copyright. All rights reserved.
Association of rosacea with demodicosis
Archives of Iranian medicine, 2007
There are controversial reports about the role of Demodex mites in pathogenesis of acne rosacea. The aim of this study was to examine the relationship between the presence and number of Demodex mites and the pathogenesis of rosacea. In this case-control study, the prevalence of Demodex mites was studied in facial biopsy of 75 patients with acne rosacea as case group, and in 75 patients with discoid lupus erythematosus and 75 patients with actinic lichen planus as control groups. The prevalence of Demodex mites in patients with acne rosacea (38.6%) was significantly higher than the patients with discoid lupus erythematosus (21.3%) and actinic lichen planus patients (10.6%) (P < 0.001). This study suggests that Demodex mites may play a role in pathogenesis of rosacea but it is not clear whether rosacea merely provides a suitable environment for multiplication of mites, or whether the mites play a role in the pathological changes.