Incidence Of Different Hepatic Lesions in Saudi Patients Using Computed Tomography (original) (raw)

The Efficacy of CT Scan in Evaluation of Hepatic Tumors taking Histopathology as Gold Standard

2021

Background and Aim: The prevalence of hepatic tumors is most common among developing countries of Asia compared to Europe and Western countries. In Pakistan, hepatic tumors are the 4thcommon disorder. The current study aims to evaluate the efficacy of hepatic tumors taking histopathology as a gold standard. Materials and Methods: This cross-sectional study wascarried out on 120 patients who underwent CT scans for hepatic tumors inradiology department of Sughra Shafi Medical Complex / Sahara Medical College, Narowal and Children Hospital &Institute of Child Health,Multan during the period of six months from 1st September 2020 to 2nd March 2021. The age range for all the patients was 29 to 80 years with mean ±SD(52±5.32) followed by hepatic tumors diagnosed based on histopathology as agold standard and assessed with CT. The prevalence of colorectal carcinoma was 22(18.33%), while other common parameters were pancreas, stomach adenocarcinoma, and biliarytree 13 (10.83%), and hepatocell...

Study of Liver Lesions using Computed Tomography

This study aimed to study the role of computed tomography (CT) in the diagnosis of liver lesions, to determine which lesion of the liver with high incidence, and to find out the Geographic distribution of the liver lesions in Sudan. This is a retrospective study was conducted at Fedail hospital, and Royal scan Center, Khartoum, Sudan included Sixty patients with focal liver lesions. The results of the study revealed that the high incidence of liver lesions was (45%) among the age group between (41-60) years old. The high incidence of liver lesions was metastasis (33.3%) and solid mass (33.3%) affected age group (41-60) years old (45%), it commonest in male (60%), most patients from center, north, and west of Sudan. The solid mass of the liver was commonest in age group (61-80) years old had an incidence of (45%), it commonest in male (65 and the most affected was right lobe of the liver (50%). This study concluded that triphasic CT scan is a good non-invasive tool and can be used as the first line for differentiating of focal liver lesions. Benign lesions like haemangioma can be reliably differentiated from malignant liver lesion; therefore unnecessary biopsies can be avoided.

Accuracy of CT-Scan for the Detection of Malignant Liver Mass

International Journal of Medical and Biomedical Studies, 2019

Background: Malignant liver mass, especially hepatocellular carcinoma (HCC), is the most common primary malignant tumour of the liver representing more than 80% of all primary hepatic malignancies. Methods: This cross sectional study was carried out in the Department of Radiology. All the clinically suspected patients having hepatic mass at any age with both sexes who were attended in hospital were taken as study population as per inclusion and exclusion criteria. Patients having hepatomegaly due to extra hepatic causes, patients who refused to undergo CT-scan, patients who refuse to do biopsy or whose biopsy result was not available and patients having known hypersensitivity reaction to contrast agent were excluded from this study. Results: Sensitivity of CT to diagnose malignant lesion was 94.12%, specificity 84.62%, accuracy 90%, positive predictive value 88.89% and negative predictive value 91.67%. Conclusion: The results of the present study therefore conclude that CT is a useful modality for the diagnosis of malignant liver masses. Since the CT diagnosis correlates with histopathological connection, it is a sensitive modality on the basis of the above findings.

Causes and Stages of Hepatocellular Carcinoma at Patient Presentation at a Tertiary Medical Center in Western Saudi Arabia

Journal of Cancer Therapy, 2014

Background: With 748,300 new cases diagnosed every year, hepatocellular carcinoma (HCC) is the 5 th and the 7 th most common cancer among males and females, respectively, and causes 7% of all cancer-related deaths. HCC represents more than 90% of primary liver cancers. Objective: The aim of the present study was to recognize the stages of HCC at presentation in patients who were diagnosed at King Abdul Aziz University Hospital (KAUH) and to identify the associated laboratory features of advance HCC. Materials and Methods: A retrospective analysis of 57 HCC patients admitted to KAUH between January 2008 and December 2012 was conducted. The diagnosis was established using ultrasound (U/S), computed tomography (CT) and/or magnetic resonance imaging (MRI), with or without a liver biopsy, as well as blood testing for alpha-fetoprotein. The following data were extracted from the medical records at KAUH: patient demographics (age, sex and nationality), laboratory results (CBC, LFT, PT, INR and alpha-fetoprotein), radiological results, biopsy results for those patients who underwent biopsy, outcomes (living, deceased or lost from the follow-up), and mortality and survival rates. Results: A total of 57 HCC patients were admitted during the study period, and 3 patients were excluded from the analysis. Of the remaining 54 patients, 44 (81.5%) were males and 10 (18.5%) were females. The mean age was 64.54 years (SD, 11.2 years; range, 31-86 years). The majority of patients were Saudis (19, 35.2%), non-Saudis (35, 64.8%), Egyptians (9, 16.6%) and Yemenis (7, 13%). The remaining 19 (35.2%) patients comprised other nationalities. Chronic hepatitis C virus was the most common cause for liver cirrhosis (35 patients, 64.8%). CT was the primary diagnostic method (37 patients 68.5%), while 9 (16.7%) cases were confirmed by adnominal MRI. Six patients (11.1%) were diagnosed with abdominal ultrasound * Corresponding author. S. Alkhayyat et al. 1304 examination and elevated alpha-fetoprotein levels. In 2 (3.7%) patients, HCC was confirmed by liver biopsy. The majority of the patients (37, 68.5%) had advanced disease. Only 21 (39%) patients underwent radio frequency appellation (RFA). The mean survival time from diagnosis to death was 5.9 months (SD, 5.7 months), and the longest survival time to death was 20 months. Conclusion: The majority of our patients presented at an advanced disease stage, and CHC was the most common underlying cause for liver cirrhosis in our cohort of HCC patients. The proper implementation of HCC screening programs for cirrhotic patients is expected to help detect the treatable stages of HCC in a timely manner.

Diagnostic Accuracy of Ultrasound for Benign and Malignant Hepatic Masses Taking Computed Tomography as Gold Standard

Pakistan Journal of Health Sciences

Detection of benign and malignant liver masses is very important for the treatment. Objectives: To determine the diagnostic accuracy of ultrasound for hepatic masses taking computed tomography as gold standard Methods: It was cross a sectional analytical study to.it involves 266 patients suffering from hepatocellular cell carcinoma age group 45 to 65 years visiting Department of Radiology THQ Hospital Hazro, both genders were included. Consecutive sampling method was used. The collection of data was done through questionnaire and analysis by using SPSS version 25. Results: This study enlisted the participation of 261 patients. The average age of all patients was 59.28 14 years, with a range of 45 to 65 years. It describes that the total number of true positive disease were 228 which was also detected on ultrasound. However, the occurrence of HCC is highest on CT scan when compared with adenoma and hemangioma. There were 28 patients with multiple lesions, with 71.4 % being malignant ...

Test Accuracy of CT-Scan for the Detection of Malignant Liver Mass

Advances in Computed Tomography, 2015

Background: Detection of malignant liver mass is very important for the treatment modalities. Objective: The purpose of the present study was to establish the usefulness of CT scan in the diagnosis of malignant hepatic mass. Methodology: This cross sectional study was carried out in the Department of Radiology and Imaging at Mymensingh Medical College Hospital (MMCH), Mymensingh, Banghabandhu Sheikh Mujib Medical University (BSMMU), Dhaka and Dhaka Medical College Hospital (DMCH), Dhaka during the period of 1st January 2006 to 31st December 2007. Patients admitted in the Department of Medicine and Department of Hepatobiliary of MMCH, BSMMU, and DMCH with the clinical diagnosis of fever, abdominal pain, anorexia, nausea/vomiting, loss of appetite, jaundice, weight loss and ascites were selected as study population. CT scan and histopathology were performed to all the patients. Result: A total number of 50 patients were recruited for this study. Mean age of all patients was 51.28 ± 14 years with a range of 17 year to 78 years. Among all patients 28 had multiple lesion, of them 71.4% was malignant and 28.6% was benign. On the other side 22 patients had solitary lesion, of them 36.4% was malignant and 63.6% was benign (p < 0.05). Sensitivity of CT to diagnose malignant lesion was 96.4%, specificity 86.4%, accuracy 92%, positive predictive value 90% and negative predictive value 95%. Conclusion: CT is a useful diagnostic tool for the detection of malignant hepatic masses. Keywords Test accuracy, CT-Scan, Malignant, Liver Mass W. Begum et al.

Hepatocarcinoma in Instituto Guatemalteco de Seguridad Social Functional Three Phase Computed Tomography as Diagnosis Tool

Gastroenterology, Hepatology & Digestive Disorders, 2018

Background: Hepatocellular-carcinoma (HCC) diagnosis can be made by imaging, if imaging is not definitely we need to individualized and include additional imaging or biopsy. However is important to determine if there is cirrhotic or non-cirrhotic liver for prognosis and treatment. In this study we aimed to compare the findings obtained for liver masses between three phase computed tomography (CT) with the anatomopathological results and characterized them epidemiologically. Methods: Using an observational, retrospective and analytic study, all the liver masses seen by functional three phase CT were included and compared with the pathology result during 2015-2017 at Instituto Guatemalteco de Seguridad Social (IGSS). Categorical variables were presented in frequency and percentages and analyzed by Chi squared of homogeneity. Normality was tested with Kolmogorov-Smirnov. Numerical data was evaluated with t-student of independent samples. At relational level a bivariate study was made, then elevated to multivariate level. To measure sensitivity and specificity we constructed receiver operating characteristics (ROC) curves and calculate area under the curve (AUC). Negative predictive value (NPV) and positive predictive value (PPV) were calculated. Results: Of 76 liver masses evaluated by three phase CT, 53% were confirmed by biopsy; 84% of HCC diagnosis were non-cirrhotic livers. In ROC curves, AUC for three phase CT for all samples was 0.646, then we stratified in cirrhotic and non-cirrhotic, AUC for cirrhotic was 0.65, PPV of 0.54 and NPV of 0.69 for HCC diagnosis. AUC for non-cirrhotic patients was 0.665, PPV of 0.67 and NPV of 0.62. Conclusion: Our findings were the opposite of global epidemiology, most of the liver masses diagnosed as HCC are in non-cirrhotic livers. Three phase CT can diagnose HCC with good sensitivity and specificity and it has better PPV in non-cirrhotic patients, nevertheless biopsy should be done because they are low risk patients.

The frequency and significance of small (less than or equal to 15 mm) hepatic lesions detected by CT

American Journal of Roentgenology, 1992

The purpose of our study was to determine the frequency of detection of small hepatic lesions (15 mm) in outpatients who had abdominal CT and to assess the significance of these lesions in the presence or absence of known malignant tumors. Contrastenhanced abdominal CT scans In 1454 patients were reviewed. In 254 patIents (17%), hepatic lesions 15 mm or smaller were detected. In 51% of these patients, lesions were judged benign on the basis of other imaging studies, biopsy results, or stability for at least 6 months as shown by CT. Lesions were judged malignant on the basis of progression seen on radiologic studies or biopsy in 22%. The other 27% of the patients had lesions that could not be classifled The majority of patients with small hepatic lesions (82%) were known to have a malignant tumor-in 51% of these patients, lesions were diagnosed as benign. No patient without a known malignant tumor had a small hepatic lesion that was determined to be malignant. Multiple small lesions were more likely to represent malignant disease than were single small lesions. We conclude that small hepatic lesions are common (seen in 17% of our patients), and that there is a high probability that hepatic lesions smaller than 15 mm are benign, even in patients known to have an extrahepatic malignant tumor.

Patterns of Hepatocellular Carcinoma on Computed Tomography at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia

Ethiopian Journal of Health Sciences, 2020

BACKGROUND: Hepatocellular cancer is the commonest liver cancer which contributes to a high incidence of morbidity and mortality in both developed and developing countries. Despite the anticipated high burden of the disease in the country, there is paucity of data on the associated risk factors and its pattern on imaging. The aim of this study was to assess Computed Tomography patterns and the risk factors of hepatocellular carcinoma.METHODS: A cross-sectional, prospective study on patients with a diagnosis of HCC on Computed Tomography examination, at Tikur Anbessa Specialized Hospital from July, 2016 to July, 2017. All patients who had characteristic Computed Tomography features and those who were diagnosed by Fine needle aspiration cytology (FNAC)/biopsy and had Computed Tomography examination were included in the study. Risk factors identified were reviewed from patients’ medical records.RESULT: A total of 70(n=70) patients were included in the study. The mean age was 50 ± 16 ye...