Formulation and Evaluation of Extended Release Matrix Tablets of Metoprolol Succinate Using Natural Polymers (original) (raw)

The objective of this study was to design and evaluate an oral extended drug delivery system for Metoprolol succinate using natural hydrophilic gums such as Xanthan Gum, Guar Gum, Pectin and Carrageenan as a release modifier. Twenty four batches were prepared by using in combination of 1:1, 1:2 and 2:1 ratios of Natural polymers and Avicel RS 581. Matrix tablets were prepared by wet granulation method and granules are coated with rate release polymers like Ethyl cellulose and Hydroxy propyl methyl cellulose. The formulations were evaluated for angle of repose, bulk density, tapped density, Compressibility Index, % LOD (Pre compression properties) and weight variation, content uniformity, friability, hardness, thickness, in vitro drug release studies(Post compression properties). Among the formulations studied formulation H-MSG 1 containing combination of Guar Gum and Avicel RS 581 (1:1) showed extended release of drug for 24 hrs with cumulative percent release of 99.46% ± 0.01%. The kinetic treatment showed that the optimized formulation followed first order kinetics and the release exponent (n) 1.199 through Korsmeyer and Peppas equation shown that the formulation follows super case II. The matrix formulation H-MSG 1 showed sustained release of Metoprolol succinate by the diffusion mechanism. On comparison with the marketed formulation, the best formulation H-MSG 1 showed similarity factor (f 2) of 80.09 indicted more significant in drug release behaviour.