BIO ACTIVE PHYTOMOLECULES AS POTENTIAL SOURCE OF ALZHEIMER'S DISEASE'S THERAPY (original) (raw)
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Plants as Potential Sources for Drug Development against Alzheimer's Disease
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that primarily affects the elderly population and is considered to be responsible for ca. 60% of all dementia in people aged 65 or older. Due to its debilitating nature, an enormous social and economic burden is placed on society. The significance of AD is further compounded as the number of identified cases is estimated to double or triple by 2050. Currently there is no cure for the disorder and much of the treatments available have been able to only delay the progression of the disease or provide symptomatic relief for a short period of time. Therefore there is a need for a different approach to the treatment of these diseases. Plants have been used since antiquity in the treatment of various diseases including cognitive disorders, such as AD. Therefore ethnopharmacological screening of plants may provide useful leads in the discovery of new drugs for AD therapy. This article reviews screening of the plants, belonging to 21 families, used in traditional systems of medicine (e.g. Chinese, Indian and European) for treatment of cognitive dysfunction. Electronic data bases were used for searching information related to the studies done on the plants in the last 20 years. Phytochemical substances such as alkaloids, biphenolic lignans, curcuminoids, caffeic acid derivatives, diterpenes, triter-penoid saponins, triterpene lactones, stilbenes and withanolides with pharmacological activities relevant to AD treatment are discussed in this review. Compounds of potential interest for further drug developmental studies have been highlighted.
ROLE OF MEDICINAL PLANTS IN MANAGEMENT OF ALZHEIMER'S AND NEURODEGENERATIVE DISEASE -REVIEW
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that primarily affects the elderly population and it is considered to be responsible for a 60% of all dementia in people aged 65 or older. Due to its unbearable nature, an enormous social and economic burden is placed on society. Currently there is no permanent heal for the disorder and much of the treatments available have been able to only delay the progression of the disease or provide symptomatic relief for a short period of time. Present are necessitating for an advance treatment of these diseases. Plants have been used since archeological find in the treatment of various diseases including cognitive disorders, such as AD. Phytochemical substances such as alkaloids (galathamine), curcuminoids, heperzine, ginkgolid, icariin, ginsenoside, carinatumins, esveratrol, berberine, rhapenticin, rhapontigenin, tenshinone, desitoindosi IX, salvianolic acid, diterpenes, triterpenoid (ursolicacids), stilbenes and withanolides were pharmacological activities relevant to treat AD. The medicinal plants have been act on multi functional molecular mechanism in AD (Senile plaque deposition, antiamyloid, neurofibrillary tangle formation and tau hyperphosphorylation).
Role of Medicinal Plants for the Treatment of Alzheimer’s Disease
Journal of pharmaceutical research international, 2021
In today's era, most of the diseases are treated by allopathic drugs. The reliance on allopathic drugs for the treatment of most diseases is gradually increasing day by day due to their rapid effects and the immediate relief to patients. However, these drugs induce some serious side effects in patients, and in some cases, the patient may die. Thus, the interest of researchers is growing day by day towards medicinal plants for the treatment of diseases. It has also been viewed that some herbal plants have great therapeutic and pharmacological effects in the treatment of Alzheimer's disease. The initial studies, which have been carried out by different researchers, demonstrated very valuable results and enlighten a ray of hope for the treatment of Alzheimer's disease which is associated with CNS disfunction. In this article, the author focused on those plants which are especially used in the treatment of Alzheimer's disease.
Medicinal plants effective against alzheimer’s disease: An update
IP International Journal of Comprehensive and Advanced Pharmacology
Alzheimer's disease (AD) is a memory-related neurodegenerative disease that affects individuals as they grow older. AD is highly devastating; beginning with memory problems and progressing to total dependency and failure to perform daily activities. Several trials have been conducted in order to discover therapeutic approaches for AD, however, the proper cure is still unavailable. Late initiation of AD drugs is argued to decrease their efficacy. While AD has no cure, symptomatic therapy can help with memory and other dementia-related issues. Due to the complexities of the underlying pathologies, the lack of diseasemodifying medications necessitates the production of newer medicinal agents and various target-based techniques. Many herbs and herbal formulations have been used for memory and cognitive enhancement in the past, and many of them have been researched thoroughly in the last few years for therapeutic efficacy in AD. The effectiveness of most herbs and plants has been confirmed in clinical trials and has been chemically tested. This study will concentrate on recent scientific results on the effectiveness of different plants in the management of AD based on their memory boosting, neuroprotective, antioxidant, and anti-inflammatory effects.
Backgrounds: Alzheimer's disease (AD) impacts a total of 30 million individuals worldwide, resulting in the impairment of brain cells. Despite the approval of medications, there are still poor results and adverse effects that continue to exist, which has led to continued research for more effective treatments. Objectives: In this study prioritize the medicinal plants and their bioactive chemicals to attract researchers and pharmaceutical companies interested in producing powerful herbal medicines and semi-synthetic drugs for the treatment of Alzheimer's disease, although minimizing any potential adverse effects. Methods: This review investigate the effective use of medicinal plants and their phytochemicals in the treatment of AD to manage its growth and relieve symptoms via improving cognitive deficits. Results: These medicinal plants and their phytochemicals contribute to the treatment of AD by protecting against cell damage induced by beta amyloid, improving memory and learning abilities, functioning as nerve tonics, and exhibiting strong antioxidant and anti-inflammatory activities. Furthermore, they have demonstrated therapeutic benefits in the management of AD. The finding suggests that several phytoconstituents/ plant metabolites are present in numerous anti-Alzheimer's plants known for their anti-Alzheimer's properties such as rosmarinic acid, quercetin, kaempferol, gallic acid, β-sitosterol, oleic acid and linalool. In addition, this article emphasizes the anti-Alzheimer's disease significance of various important phytochemicals. Conclusion: The review proposes that medicinal plants and their bioactive phytochemicals hold potential as a viable alternative treatment for AD. The utilization of these medicinal plants can improve memory and decrease the likelihood of developing Alzheimer's disease in the future.
Role of Medicinal Plants in Neurodegenerative Diseases with Special Emphasis to Alzheimer's Disease
2014
Alzheimer's disease is an age-associated, irreversible, progressive neurodegenerative disease that is characterized by severe memory loss, unusual behavior, personality changes and a decline in memory function. It is the most common form of dementia and affects an estimated 10 million people worldwide. Alzheimer’s disease demolishes the vital brain cells, causing trouble with memory, thinking and behavior, brutal enough to affect work, lifelong hobbies and social life. Recognized factors in Alzheimer's disease include acetylcholine deficiency, free radicals and inflammation of the brain tissue. There is no cure for Alzheimer's disease, but drugs designed to slow down the disease progression are available. Some herbs may help to improve brain function, but scientific evidence to prove that they can treat Alzheimer's disease. Medicinal plants have been the single most productive source of leads for the development of drugs, and over a hundred new products are already i...
The Role of Natural Products in Pharmacotherapy of Alzheimer�s Disease
Ethnobotanical Leaflets, 2005
Alzheimer's disease is characterized by forgetfulness, disturbance in memory and loss of mental abilities. The final outcome of the disease is loss of personality and intellectual functions. Alzheimer's disease is common cause of dementia particularly after the age of 70 years. Cholinesterase inhibitors are used for the treatment of Alzheimer's dementia, but due to unpleasant side effect; these groups of drugs can not be used for long term treatment. Phyto drugs are being investigated for possible cure of Alzheimer's disease. A number of constituents like Galanthamine, Huperzine, Hyperforin, & Desoxy-peganine have shown promising result. Some Ayurvedic herbs like Bacopa monneria (Bacosides) have recently gained attention because of memory enhancing activity. The article deals with latest findings in phytotherapy of Alzheimer's disease.
Journal of Young Pharmacists, 2023
Alzheimer's disease (AD), the most common type of dementia, is a progressive neurodegenerative disease severely affecting memory and cognitive function. It causes linguistic and visuo-spatial deficiencies, and behavioral problems like indifference, aggressiveness and depression as disease progresses advanced stages. No cure is available for Alzheimer's, though symptomatic treatment improves memory and other symptoms. Natural products ease the symptoms of many kinds of diseases and offer a treatment option for many diseases at least successfully slowing the progress. Medicinal plants and plant products have been historically employed to improve brain function and treat memory disorders like amnesia, dementia. Though, various studies have described the utility of plants for treatment of Alzheimer's, but with limited scientific evidence. Though, it has been reported that early start of utilization memory enhancing agents and brain tonics can be beneficial in AD. The present review is to summaries the herbal medicines which have reported to have some kind of CNS activity and may be utilized for slowing progression, symptomatic treatment and research in the treatment of Alzheimer's disease (AD) and its related symptoms.
Pharmacological and Herbal remedies in the Management of Neurodegenerative Disorder (Alzheimer’s)
International Journal of Pharmacognosy and Life Sciences, 2021
Alzheimer's disease (AD) is a progressive, neurodegenerative disorder and has become a great health problem particularly among the elderly people, generally occurs after the age of 55 years and increase in incidence with advancing age, affecting nearly 25 million people worldwide. Alzheimer's disease (AD) was first identified by the German psychiatrist, Alois Alzheimer, in 1907. People with this disease may exhibit symptoms of short-term memory loss, diminished motor skills, inefficient coordination and impaired intellectual capabilities. The cause of AD is not exactly known, but is thought to include both genetic and environmental factors (multifactorial). There is no known cure for Alzheimer's disease, since it is not possible to reverse the death of brain cells but the symptoms can be managed by some pharmacological agents and herbal remedies. The herbal remedies are becoming more popular in the recent years and providing very promising benefits to the patients suffering from AD. Several clinical trials using herbal mixtures are also going on and will hopefully show positive results for treating AD in the future. This paper reviews the Pathophysiology of AD along with the synthetic drugs and herbal medicines which are used for the Management of AD.
International journal of health sciences
Treatment of Alzheimer's Disease is currently limited only to slowing the severity of the symptoms felt by patients, not curing Alzheimer's itself. Current FDA-approved therapies such as Donepezil, Tacrine, Galantamine, Rivastigmine, and Memantine have quite disturbing side effects for Alzheimer's sufferers, as well as the mechanism of action of these drugs which is dominated by working as AChE inhibitors. On the other hand, the hypothesis for Alzheimer's causes is varied. Another study also states that the Non-Steroid Anti-Inflammatory Drugs (NSAIDs) can be given to people with Alzheimer's, this is pro and cons because in one study NSAIDs can reduce the risk of Alzheimer's progression through inhibiting inflammatory process on AD pathogenesis; on the contrary, other studies have argued that giving NSAIDs to Alzheimer's sufferers is not necessary. Despite administering Alzheimer's drugs and NSAIDs which have adverse side effects on long-term use as we...