BIO ACTIVE PHYTOMOLECULES AS POTENTIAL SOURCE OF ALZHEIMER'S DISEASE'S THERAPY (original) (raw)

Alzheimer's disease is an age allied neurodegenerative disease characterized by loss of memory, unusual behavior, personality change and a decline in cognitive function. It is crucial to therapeutic important that could progression of Alzheimer's disease would spectacularly reduce the number of cases in the next 50 years. Medicinal plants have been the mainstream prolific source of leads for the development of drugs formulation, and a lot of new products are previously in clinical developed. Scientific studies have determined the use of various medicinal plants and their constituents for treatment of Alzheimer's disease the mechanism of their action is not appropriately described and much of the treatment are available have been able to only delay the progression of the disease. Consequently there is a need for a different approach to the treatment of these diseases. Plants have been used since antiquity in the treatment of various diseases including cognitive disorder, such as AD. Therefore ethanopharmacological screening of plants may provide useful leads in the discovery of new drug for AD therapy. This article reviews screening of the plants, belonging to 21 families, used in the traditional system of medicine (e.g. Chinese, India and European) for treatment of Alzheimer's disease. Electronic data bases were used for searching information related to the studies done on the plants in the last 10 years. Phytochemical substance such as flavonoids, polyphenols, triterpenes, sterols, alkaloids caffeic acid derivative, and stilbenes with pharmacological activities relevant to AD treatment are discussed in this review. Phytochemical for advance drug development studies have been highlighted.