Fast Dissolving Tablets: As a Preferred Alternative to conventional tablets (original) (raw)
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A review on fast dissolving tablets (FDTs)
The oral route is the most acceptable routes among the various routes for different age group of the patients because it is regarded as safest, most convenient and economical route. Therefore, recently researcher and pharmaceutical companies developed the fast dissolving tablet (FDT) by modifying the physiochemical parameter of drugs to their need with improved patient compliance and convenience. FDTs are solid dosages forms which dissolve rapidly in saliva without chewing and additional water. USFDA define FDTs to be the solid oral preparation that disintegrate rapidly in the oral cavity with an in-vitro disintegration time of 30 seconds or less. FDTs improved patient compliance and also overcome the disadvantages of conventional dosage form especially dysphagia (difficulty in swallowing) in pediatric and geriatric patients. Over the last decade FDTs have grown steadily in demand and importance as a convenient, potentially safer alternative to conventional tablets and capsules. The growing importance for this is due to the potential advantages offered by this technology for various kinds of patients suffering from different diseases and disabilities. This review includes ideal properties, characteristics, challenges in formulation, suitability of drug candidates, various technologies developed for FDT, patented technologies, evaluation methods and various marketed products.
Review of Fast-dissolving Tablets - A New Era in Brand-new Drug Delivery Systems
Journal of Pharmaceutical Research International, 2022
Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop FDTs with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs, or orally disintegrating tablets, are highly helpful for children and old people who have trouble swallowing standard pills and capsules .This review focuses on lyophilization, moulding, sublimation, and ...
International Journal of Scientific Research in Chemistry, 2020
Due to the increasing demand of novel drug delivery, the fast disintegrating drug delivery system has become one of the mile stone in the novel drug delivery system. The introduction of fast dissolving drug delivery system has encountered the delivery of conventional dosage form. Recent advances in the formulation development and processing technologies meet the efforts to achieve more sophisticated drug delivery system. Mouth dissolving tablets need to be formulated for pediatric, geriatric, psychotic patients, bedridden and for those who are busy in travelling and may not have to assess to water. The drugs delivered in MDT’S may be absorbed in the pregastric sites of highly permeable buccal and mucosal tissues of the oral cavity and they may be suitable of low molecular weight and highly permeable drugs.
A Review of Formulation Technology for Recent Advancements in Fast Dissolving Tablets
Zenodo (CERN European Organization for Nuclear Research), 2023
The design of the oral drug delivery system, which is still the dominant method of drug delivery despite a number of drawbacks, must take into account the ease of administration and increased patient compliance. Due to the insufficient development of the muscular and neurological systems in children, as well as cases of elderly individuals with Parkinson's disease or hand tremors, fast-dissolving tablets have become one of the most well-liked and widely recognised dose forms. Today's solid dosage forms, such as capsules and tablets, are dealing with issues like dysphagia, which leads to numerous instances. In mouth dissolving tablets superdisintegrants are incorporated in right amount for quick disintegration with improved bioavailability.FDTs either disintegrate or dissolve rapidly in saliva without the need for water. Real fast-dissolving tablets are made to dissolve in saliva incredibly quicklyin less than 60 seconds. By using different processes, such as direct compression, tablet moulding, freeze drying, and spray drying nanonization, one can create a drug delivery system that dissolves quickly.This article provides a brief description of FDTs, including their definition, benefits, uses, key characteristics, drawbacks, problems in their development, Technology used for manufacturing of fast dissolving tablets, Common excipients used in fast dissolving tablets and commercially available fastdissolving tablet formulations.
Fast disintegrating tablets: Opportunity in drug delivery system
Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral drug delivery remains the preferred route for administration of various drugs. Recent developments in the technology have prompted scientists to develop FDTs with improved patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs or orally disintegrating tablets provide an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the FDT properties, such as spray drying and use of disintegrants. In addition, taste-masking technologies, experimental measurements of disintegration times, and dissolution are also discussed.
Fast Dissolving Tablets: A Novel Drug Delivery System
2017
In today’s era, many novel drug delivery approaches have been developed which are aimed at both to increase the performance of the dosage form as well as patient compliance. A fast dissolving tablet is one such novel drug delivery system. FDT dissolves or disintegrates in the oral cavity within seconds without intake of water, has drawn a great attention. Fast dissolving tablet is the safest, most convenient and economical having highest patient compliance especially for geriatric, pediatric, bedridden patients, patients who have swallowing difficulties (dysphagia) and for patients who are busy, travelling or have no access to water. The main advantage of FDT is its quick disintegration in the oral cavity without the aid of water or chewing. It has provided new area of research and development for both industries and academics. This article reviews the importance and unique concept of the fast dissolving tablets with an overview of oral mucosa for drug delivery through it. It also r...
Overview of formulation and evaluation of fast dissolving tablet: A promising tablet dosage form
Journal of Applied Pharmaceutical Research, 2020
The science of drug delivery has been increasingly innovative and quick evolving with everincreasing demand in the current scientific scenario. Fast dissolving tablet (FDT) is one of those forms of an advanced and special drug delivery system that is rapidly gaining a lot of attention in the rapid dissolution technology research sector. Fast dissolving tablets appear as one of the common and widely accepted dosage types, particularly for paediatric patients due to incomplete muscle and nervous system development and a form of geriatric patients with Parkinson's disease or hand shivering. The most popular administrative path for different medications has drawbacks such as first-pass metabolism, psychotic patients, bedridden and Uncollaborative patients, is the oral delivery type and oral path FDTs disintegrate or quickly dissolve in the saliva without requiring water. Within few seconds, FDT will dissolve within saliva for approximately 60 seconds and these comprises will dissolve even faster
Novel study in fast dissolving drug delivery system: a review
Indian Journal of Pharmaceutical and Biological Research, 2015
Novel drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and bio-chemical parameters pertinent to their performance. Despite tremendous advancements in drug delivery, the oral route remains the perfect route for the administration. Novel drug delivery system assists to achieve better patient compliance. Fast dissolving tablets are one of them.FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. FDDT formulation combines the advantage of both liquid and conventional tablet formulation while also offering advantage over both traditional dosage forms. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast- dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are m...
Fast Disintegrating Tablets - a New Era in Novel Drug Delivery System
International Journal of Advanced Research, 2022
Among all dosage forms, fast-Disintegrating tablets are one of the most commonly used dosage forms, especially in children, because their nervous system and muscular system are not well developed compared to them in adults. and in adult patients with Parkinsons disease or hand tremors. Some fixed dosage forms, such as capsules and tablets, now have difficulty swallowing (dysphagia), which results in many cases of non-compliance and renders therapy ineffective. The most preferred routes of administration for various drugs are oral dosage forms and the oral route with specific limitations such as first-pass metabolism by the liver, psychiatric patients, at-risk patients, and non-cooperators. FDTs dissolve easily in saliva without the need for water. Fast- Disintegrating tablets dissolve in saliva in a minimum of less than 60 seconds., And these are really fast-digesting tablets. FDT formulations contain super disintegrants to increase the rate of tablet degradation in the buccal cavit...